Malignant Pleural Mesothelioma Produces Functional Granulocyte-Colony Stimulating Factor
We report a patient with diffuse malignant pleural mesothelioma showingmarked elevation of neutrophils. The level of serum granulocyte-colonystimulating factor (G-CSF) was elevated (138 pg/mL; normal range,< 20 pg/mL). The patient died 6 weeks after disease progression hadbeen noted, and immunohi...
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| Veröffentlicht in: | Chest 2001-03, Vol.119 (3), p.981-983 |
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| container_title | Chest |
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| creator | Kasuga, Ikuma Ishizuka, Shirou Minemura, Kazushige Utsumi, Kenta Ohyashiki, Kazuma Serizawa, Hiromi |
| description | We report a patient with diffuse malignant pleural mesothelioma showingmarked elevation of neutrophils. The level of serum granulocyte-colonystimulating factor (G-CSF) was elevated (138 pg/mL; normal range,< 20 pg/mL). The patient died 6 weeks after disease progression hadbeen noted, and immunohistochemistry using a specific monoclonalantibody against recombinant G-CSF at autopsy demonstrated that themalignant mesothelioma cells actually produced G-CSF. Only three casesof malignant pleural mesothelioma, including the current patient, havebeen reported to produce G-CSF. We demonstrated an elevated serum levelof G-CSF and G-CSF-bearing tumor cells by immunochemistry. |
| doi_str_mv | 10.1378/chest.119.3.981 |
| format | Article |
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The level of serum granulocyte-colonystimulating factor (G-CSF) was elevated (138 pg/mL; normal range,< 20 pg/mL). The patient died 6 weeks after disease progression hadbeen noted, and immunohistochemistry using a specific monoclonalantibody against recombinant G-CSF at autopsy demonstrated that themalignant mesothelioma cells actually produced G-CSF. Only three casesof malignant pleural mesothelioma, including the current patient, havebeen reported to produce G-CSF. 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| ispartof | Chest, 2001-03, Vol.119 (3), p.981-983 |
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| subjects | Biological and medical sciences Granulocyte Colony-Stimulating Factor - biosynthesis Granulocyte Colony-Stimulating Factor - blood granulocyte-colony stimulating factor Humans Immunoenzyme Techniques leukocytosis Male malignant mesothelioma Medical sciences Mesothelioma - metabolism Middle Aged Pleural Neoplasms - metabolism Pneumology Tumors of the respiratory system and mediastinum |
| title | Malignant Pleural Mesothelioma Produces Functional Granulocyte-Colony Stimulating Factor |
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