Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin

beta 2-Microglobulin is a small, major histocompatibility complex class I-associated protein that undergoes aggregation and accumulates as amyloid deposits in human tissues as a consequence of long-term haemodialysis. The folding process of this amyloidogenic protein has been studied in vitro by dil...

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Veröffentlicht in:	Journal of molecular biology 2001-03, Vol.307 (1), p.379-391
Hauptverfasser:	Chiti, F, Mangione, P, Andreola, A, Giorgetti, S, Stefani, M, Dobson, C M, Bellotti, V, Taddei, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis - metabolism Anilino Naphthalenesulfonates - chemistry beta 2-Microglobulin - chemistry beta 2-Microglobulin - physiology Circular Dichroism Escherichia coli Fluorescence Humans Kinetics Models, Molecular Peptidylprolyl Isomerase - chemistry Protein Denaturation Protein Folding Spectrophotometry, Ultraviolet
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