Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme

The hamster ornithine decarboxylase antizyme (ODC-Az) cDNA was transfected into the hamster malignant oral keratinocyte cell line, HCPC-1. Ectopic expression of ODC-Az resulted in the reversion of malignant phenotypes and alteration of DNA methylation status of CCGG sites. The phenotypes examined in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2001-01, Vol.20 (1), p.24-33
Hauptverfasser:	TSUJI, Takanori, USUI, Satomi, AIDA, Tadateru, TACHIKAWA, Tetsuhiko, HU, Guo-Fu, SASAKI, Akira, MATSUMURA, Tomohiro, TODD, Randy, WONG, David T. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Animals Antineoplastic Agents - administration & dosage Biological and medical sciences Biomarkers, Tumor - biosynthesis Cell cycle Cell Cycle - genetics Cell differentiation Cell Differentiation - genetics Cell differentiation, maturation, development, hematopoiesis Cell Division - genetics Cell physiology Cloning Cricetinae Culture Media Decarboxylation Dinucleotide Repeats - genetics DNA DNA Methylation DNA methyltransferase Enzyme Activation - genetics Enzymes Epithelial Cells - enzymology Epithelial Cells - metabolism Epithelial Cells - pathology Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genetic aspects Growth Inhibitors - administration & dosage Injections, Subcutaneous Intracellular Fluid - metabolism involucrin Keratinocytes Keratinocytes - enzymology Keratinocytes - metabolism Keratinocytes - pathology Maxillofacial surgery Methylation Mice Mice, Nude Molecular and cellular biology Mouth Mucosa - enzymology Mouth Mucosa - metabolism Mouth Mucosa - pathology ODC-Az gene Oral cancer ornithine decarboxylase Ornithine Decarboxylase - metabolism Ornithine Decarboxylase Inhibitors Phenotype Physiological aspects Polyamines Protein Biosynthesis Proteins Proteins - administration & dosage Proteins - physiology S-Adenosylmethionine - metabolism Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!