In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo beta-adrenergic receptor kinase (betaARK1) inhibition in a model of chronic left ventricu...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2001-03, Vol.103 (9), p.1311-1316
Hauptverfasser:	SHAH, Ashish S, WHITE, David C, EMANI, Sitaram, KYPSON, Alan P, LILLY, R. Eric, WILSON, Katrina, GLOWER, Donald D, LEFKOWITZ, Robert J, KOCH, Walter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals beta-Adrenergic Receptor Kinases Biological and medical sciences Cardiology. Vascular system Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Gene Expression Gene Transfer Techniques Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles - metabolism Heart Ventricles - physiopathology Male Medical sciences Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - therapy Rabbits Transgenes - genetics
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