Retinol secretion by the lacrimal gland
In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1986-08, Vol.27 (8), p.1261-1268 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Ubels, JL Foley, KM Rismondo, V |
| description | In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats, and it is concluded that the lacrimal gland is the source of retinol in the tears. Dose-response studies show that intravenously administered pilocarpine and intra-arterial acetylcholine stimulate secretion of retinol by the lacrimal gland. Intravenous administration of vasoactive intestinal peptide (VIP) also stimulates retinol secretion in a dose-response manner. These observations are similar to the effects of cholinergic drugs and VIP on protein secretion by the lacrimal gland. |
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Retinol was identified in the lacrimal gland fluid of rabbits and rats, and it is concluded that the lacrimal gland is the source of retinol in the tears. Dose-response studies show that intravenously administered pilocarpine and intra-arterial acetylcholine stimulate secretion of retinol by the lacrimal gland. Intravenous administration of vasoactive intestinal peptide (VIP) also stimulates retinol secretion in a dose-response manner. These observations are similar to the effects of cholinergic drugs and VIP on protein secretion by the lacrimal gland.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 3733370</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Bethesda, MD: ARVO</publisher><subject>Acetylcholine - pharmacology ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Eye and associated structures. 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Psychology ; Lacrimal Apparatus - drug effects ; Lacrimal Apparatus - secretion ; Male ; Pilocarpine - pharmacology ; Rabbits ; Rats ; Rats, Inbred Strains ; Rats, Inbred WKY ; Secretory Rate - drug effects ; Tears - analysis ; Tears - secretion ; Vasoactive Intestinal Peptide - pharmacology ; Vertebrates: nervous system and sense organs ; Vitamin A - analysis ; Vitamin A - secretion</subject><ispartof>Investigative ophthalmology & visual science, 1986-08, Vol.27 (8), p.1261-1268</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8801372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3733370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ubels, JL</creatorcontrib><creatorcontrib>Foley, KM</creatorcontrib><creatorcontrib>Rismondo, V</creatorcontrib><title>Retinol secretion by the lacrimal gland</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats, and it is concluded that the lacrimal gland is the source of retinol in the tears. Dose-response studies show that intravenously administered pilocarpine and intra-arterial acetylcholine stimulate secretion of retinol by the lacrimal gland. Intravenous administration of vasoactive intestinal peptide (VIP) also stimulates retinol secretion in a dose-response manner. These observations are similar to the effects of cholinergic drugs and VIP on protein secretion by the lacrimal gland.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lacrimal Apparatus - drug effects</subject><subject>Lacrimal Apparatus - secretion</subject><subject>Male</subject><subject>Pilocarpine - pharmacology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Inbred WKY</subject><subject>Secretory Rate - drug effects</subject><subject>Tears - analysis</subject><subject>Tears - secretion</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vitamin A - analysis</subject><subject>Vitamin A - secretion</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0tLw0AUhQdRaq3-BCEL0VVg3o-lFF9QEETXw2Ryp4lMk5pJCf33jhh0dQ-cj3PPOUFLIgQthdLsFC0x4bLEHPNzdJHSJ8aUEIoXaMEUY0zhJbp7g7Ht-lgk8EOWfVdUx2JsoIjOD-3OxWIbXVdforPgYoKr-a7Qx-PD-_q53Lw-vazvN2VDpRxL7SvpNBeBi5wfwHjug6klE1oGblQFQIzizMkQAtAaG005SONzMSy9Yyt0-5u7H_qvA6TR7trkIeYO0B-SVdIIoQjN4PUMHqod1Hb_U3Y42nlZ9m9m3yXvYhhc59v0h2mNCVP0_1_TbpupHcCmvDnmUGKnaaLKakuoJOwb1DljPg</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Ubels, JL</creator><creator>Foley, KM</creator><creator>Rismondo, V</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Retinol secretion by the lacrimal gland</title><author>Ubels, JL ; Foley, KM ; Rismondo, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-8cb6a845f45337fe9c4cf9d63586f497bee19743a6fffe2d09824e69c21106ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lacrimal Apparatus - drug effects</topic><topic>Lacrimal Apparatus - secretion</topic><topic>Male</topic><topic>Pilocarpine - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Inbred WKY</topic><topic>Secretory Rate - drug effects</topic><topic>Tears - analysis</topic><topic>Tears - secretion</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vitamin A - analysis</topic><topic>Vitamin A - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ubels, JL</creatorcontrib><creatorcontrib>Foley, KM</creatorcontrib><creatorcontrib>Rismondo, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ubels, JL</au><au>Foley, KM</au><au>Rismondo, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinol secretion by the lacrimal gland</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>27</volume><issue>8</issue><spage>1261</spage><epage>1268</epage><pages>1261-1268</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats, and it is concluded that the lacrimal gland is the source of retinol in the tears. Dose-response studies show that intravenously administered pilocarpine and intra-arterial acetylcholine stimulate secretion of retinol by the lacrimal gland. Intravenous administration of vasoactive intestinal peptide (VIP) also stimulates retinol secretion in a dose-response manner. These observations are similar to the effects of cholinergic drugs and VIP on protein secretion by the lacrimal gland.</abstract><cop>Bethesda, MD</cop><pub>ARVO</pub><pmid>3733370</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1986-08, Vol.27 (8), p.1261-1268 |
| issn | 0146-0404 1552-5783 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetylcholine - pharmacology Animals Biological and medical sciences Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Lacrimal Apparatus - drug effects Lacrimal Apparatus - secretion Male Pilocarpine - pharmacology Rabbits Rats Rats, Inbred Strains Rats, Inbred WKY Secretory Rate - drug effects Tears - analysis Tears - secretion Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs Vitamin A - analysis Vitamin A - secretion |
| title | Retinol secretion by the lacrimal gland |
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