Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria
The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pret...
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| Veröffentlicht in: | The Journal of infectious diseases 2001-04, Vol.183 (7), p.1161-1164 |
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| container_title | The Journal of infectious diseases |
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| creator | Chiwakata, Collins Batsirai Manegold, Christoph Bönicke, Lars Waase, Inge Jülch, Claudia Dietrich, Manfred |
| description | The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination |
| doi_str_mv | 10.1086/319283 |
| format | Article |
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Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P<.001 among all subgroups). Six of 7 patients with PCT concentrations >25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/319283</identifier><identifier>PMID: 11237849</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Blood ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Concise Communications ; Disease Progression ; Epidemiology ; Falciparum malaria ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Germany ; Glycoproteins - blood ; Human protozoal diseases ; Humans ; Infections ; Infectious diseases ; Malaria ; Malaria, Falciparum - blood ; Malaria, Falciparum - mortality ; Medical sciences ; Microbiology ; Mortality ; Parasitemia ; Parasites ; Parasitic diseases ; Plasmodium falciparum ; Pretreatment ; procalcitonin ; Protein Precursors - blood ; Protozoal diseases ; Risk Factors ; Tropical medicine ; Virology</subject><ispartof>The Journal of infectious diseases, 2001-04, Vol.183 (7), p.1161-1164</ispartof><rights>Copyright 2001 Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 1, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-d7639f0c491fff9b5298839f3147367793035ac108e5f6957373317b324b4feb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111181$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111181$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14157216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11237849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiwakata, Collins Batsirai</creatorcontrib><creatorcontrib>Manegold, Christoph</creatorcontrib><creatorcontrib>Bönicke, Lars</creatorcontrib><creatorcontrib>Waase, Inge</creatorcontrib><creatorcontrib>Jülch, Claudia</creatorcontrib><creatorcontrib>Dietrich, Manfred</creatorcontrib><title>Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P<.001 among all subgroups). Six of 7 patients with PCT concentrations >25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Concise Communications</subject><subject>Disease Progression</subject><subject>Epidemiology</subject><subject>Falciparum malaria</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Glycoproteins - blood</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - mortality</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mortality</subject><subject>Parasitemia</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum</subject><subject>Pretreatment</subject><subject>procalcitonin</subject><subject>Protein Precursors - blood</subject><subject>Protozoal diseases</subject><subject>Risk Factors</subject><subject>Tropical medicine</subject><subject>Virology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFr1TAUxoMo7m7qf6BEQd-qSZM2yePcnBM3LFNB9hJOexPMXdtck1Tdf29KL7sgiHlJON_vfOGcD6EnlLymRNZvGFWlZPfQilZMFHVN2X20IqQsCyqVOkCHMW4IIZzV4iE6oLRkQnK1QlMTfAd955If3YghYsANBBhMMgF7i09dNBAN_mx-muDSLYZxja9cvJnFSx8S9HM19zaQnBlTxL9c-o6bHuLg124asJ39txDy8xJ6CA4eoQe5GM3j3X2Evp69-3JyXlx8ev_h5Pii6DhXqViLmilLOq6otVa1VamkzBVGuciDCMUIq6DLCzCVrVUlmGCMipaVvOXWtOwIvVp8t8H_mExMenCxM30Po_FT1CI3cVXR_4JUKEIllxl88Re48VMY8xC6LJkinFO-d-uCjzEYq7fBDRBuNSV6jksvcWXw2c5tagez3mO7fDLwcgdAzDHZAGPn4p7jtBIlrTP3fOH8tP33Z08XZhOTD3cUIzQfOe-gWHQXk_l9p0O40XXebKXPv13r5qOU11flmX7L_gDVrr0d</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Chiwakata, Collins Batsirai</creator><creator>Manegold, Christoph</creator><creator>Bönicke, Lars</creator><creator>Waase, Inge</creator><creator>Jülch, Claudia</creator><creator>Dietrich, Manfred</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria</title><author>Chiwakata, Collins Batsirai ; Manegold, Christoph ; Bönicke, Lars ; Waase, Inge ; Jülch, Claudia ; Dietrich, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-d7639f0c491fff9b5298839f3147367793035ac108e5f6957373317b324b4feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Concise Communications</topic><topic>Disease Progression</topic><topic>Epidemiology</topic><topic>Falciparum malaria</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Glycoproteins - blood</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - blood</topic><topic>Malaria, Falciparum - mortality</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Mortality</topic><topic>Parasitemia</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum</topic><topic>Pretreatment</topic><topic>procalcitonin</topic><topic>Protein Precursors - blood</topic><topic>Protozoal diseases</topic><topic>Risk Factors</topic><topic>Tropical medicine</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiwakata, Collins Batsirai</creatorcontrib><creatorcontrib>Manegold, Christoph</creatorcontrib><creatorcontrib>Bönicke, Lars</creatorcontrib><creatorcontrib>Waase, Inge</creatorcontrib><creatorcontrib>Jülch, Claudia</creatorcontrib><creatorcontrib>Dietrich, Manfred</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiwakata, Collins Batsirai</au><au>Manegold, Christoph</au><au>Bönicke, Lars</au><au>Waase, Inge</au><au>Jülch, Claudia</au><au>Dietrich, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>183</volume><issue>7</issue><spage>1161</spage><epage>1164</epage><pages>1161-1164</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P<.001 among all subgroups). Six of 7 patients with PCT concentrations >25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11237849</pmid><doi>10.1086/319283</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Biomarkers - blood Blood Calcitonin - blood Calcitonin Gene-Related Peptide Concise Communications Disease Progression Epidemiology Falciparum malaria Follow-Up Studies Fundamental and applied biological sciences. Psychology Germany Glycoproteins - blood Human protozoal diseases Humans Infections Infectious diseases Malaria Malaria, Falciparum - blood Malaria, Falciparum - mortality Medical sciences Microbiology Mortality Parasitemia Parasites Parasitic diseases Plasmodium falciparum Pretreatment procalcitonin Protein Precursors - blood Protozoal diseases Risk Factors Tropical medicine Virology |
| title | Procalcitonin as a Parameter of Disease Severity and Risk of Mortality in Patients with Plasmodium falciparum Malaria |
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