Identification of a Matrix-Degrading Phenotype in Human Tuberculosis In Vitro and In Vivo

Tuberculous meningitis is characterized by cerebral tissue destruction. Monocytes, pivotal in immune responses to Mycobacterium tuberculosis, secrete matrix metalloproteinase-9 (MMP-9), which facilitates leukocyte migration across the blood-brain barrier, but may cause cerebral injury. In vitro, hum...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-03, Vol.166 (6), p.4223-4230
Hauptverfasser:	Price, Nicholas M, Farrar, Jeremy, Chau, Tran Thi Hong, Mai, Nguyen Thi Hoang, Hien, Tran Tinh, Friedland, Jon S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cell Line Enzyme Activation - genetics Extracellular Matrix - enzymology Extracellular Matrix - microbiology Extracellular Matrix - pathology Female Gene Expression Regulation Humans Leukocyte Count Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - enzymology Meningitis, Bacterial - metabolism Meningitis, Bacterial - pathology Meningitis, Viral - cerebrospinal fluid Meningitis, Viral - enzymology Meningitis, Viral - metabolism Meningitis, Viral - pathology Monocytes - enzymology Monocytes - metabolism Monocytes - microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Phenotype TIMP-1 protein TIMP1 protein Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Transcription, Genetic Tuberculosis, Meningeal - cerebrospinal fluid Tuberculosis, Meningeal - enzymology Tuberculosis, Meningeal - microbiology Tuberculosis, Meningeal - pathology
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