Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease
A herd of swine affected by Willebrand's disease was begun in 1967 at the Mayo Clinic in order to study the inherited hemostatic abnormality in swine as a model for the human disease. Affected individuals have bleeding times in excess of 15 minutes, extremely low levels of Willebrand factor (&l...
Gespeichert in:
| Veröffentlicht in: | The Journal of heredity 1986-05, Vol.77 (3), p.179-182 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 182 |
|---|---|
| container_issue | 3 |
| container_start_page | 179 |
| container_title | The Journal of heredity |
| container_volume | 77 |
| creator | Thiele, G.L Rempel, W.E Fass, D.N Bowie, E.J.W Stewart, M Zoecklein, L |
| description | A herd of swine affected by Willebrand's disease was begun in 1967 at the Mayo Clinic in order to study the inherited hemostatic abnormality in swine as a model for the human disease. Affected individuals have bleeding times in excess of 15 minutes, extremely low levels of Willebrand factor (< 0.25 percent of normal), and decreased levels of VIII coagulant activity. Individuals with long bleeding times, higher levels of Willebrand factor and normal levels of VIII coagulant activity began to appear in the colony. It is hypothesized that this new (N) condition is inherited as a simple autosomal recessive (N/n) at a locus separate and independent of the similarly autosomal recessive (A/a) von Willebrand locus. In addition, the Willebrand locus is eplstatic to the N locus, i.e., individuals will only express the new condition provided there is at least one normal allele at the von Willebrand locus. Therefore, individuals with genotype aa—are all von Willebrand phenotyplcally, and A-nn individuals have the new disease. |
| doi_str_mv | 10.1093/oxfordjournals.jhered.a110211 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76952635</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14660965</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-1e020abb2884123af587f8da7b3fc80f71983f4d14434be8f4402bd4c2e60f23</originalsourceid><addsrcrecordid>eNqFkcFu1DAURS0EKkPhB5CQsqCwymD7ObazYIFaYCoqFUERiI3lJM-th4zT2hlN-Xs8SlqJVVeWfM-7fjom5IjRJaM1vBtu3RC79bCNwfZpub7CiN3SMkY5Y4_IgglZlQoAHpMFpZyXrKLwlDxLaU0pZVVND8gBCK1BwIJ8Ow25wI82tFgMrrBFwF3R9IidD5dF5xPahIUPOclgt2fSzgcsdn68Kn76vscm2tC9TXfwc_LE5c3wxXwekotPHy-OV-XZ-efT4w9nZStAjSVDyqltGq61YBysq7RyurOqAddq6hSrNTjRMSFANKidEJQ3nWg5Suo4HJI3U-11HG62mEaz8anFvrcBh20yStYVl1A9CGZhktZyD76fwDYOKUV05jr6jY1_DaNm7978795M7s3sPs-_mh_aNpt8fzc9y8756zm3qbW9y9pan-4xrRSTus5YOWE-jXh7H9v4x0gFqjKrX7_NyclXqOQKzJfMv5x4ZwdjL2Ou_PFdq_zZVMI_ojuq5w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14660965</pqid></control><display><type>article</type><title>Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>Thiele, G.L ; Rempel, W.E ; Fass, D.N ; Bowie, E.J.W ; Stewart, M ; Zoecklein, L</creator><creatorcontrib>Thiele, G.L ; Rempel, W.E ; Fass, D.N ; Bowie, E.J.W ; Stewart, M ; Zoecklein, L</creatorcontrib><description>A herd of swine affected by Willebrand's disease was begun in 1967 at the Mayo Clinic in order to study the inherited hemostatic abnormality in swine as a model for the human disease. Affected individuals have bleeding times in excess of 15 minutes, extremely low levels of Willebrand factor (< 0.25 percent of normal), and decreased levels of VIII coagulant activity. Individuals with long bleeding times, higher levels of Willebrand factor and normal levels of VIII coagulant activity began to appear in the colony. It is hypothesized that this new (N) condition is inherited as a simple autosomal recessive (N/n) at a locus separate and independent of the similarly autosomal recessive (A/a) von Willebrand locus. In addition, the Willebrand locus is eplstatic to the N locus, i.e., individuals will only express the new condition provided there is at least one normal allele at the von Willebrand locus. Therefore, individuals with genotype aa—are all von Willebrand phenotyplcally, and A-nn individuals have the new disease.</description><identifier>ISSN: 0022-1503</identifier><identifier>EISSN: 1465-7333</identifier><identifier>DOI: 10.1093/oxfordjournals.jhered.a110211</identifier><identifier>PMID: 3488343</identifier><identifier>CODEN: JOHEA8</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; BLOOD COAGULATION ; BLOOD DISORDERS ; CERDO ; COAGULACION SANGUINEA ; COAGULATION SANGUINE ; Female ; FENOTIPOS ; GENE ; GENE RECESSIF ; GENES ; GENES RECESIVOS ; Genetic Carrier Screening ; Hematologic and hematopoietic diseases ; Hemostasis ; HEREDITE ; HERENCIA ; INHERITANCE ; Male ; Medical sciences ; Pedigree ; PHENOTYPE ; PHENOTYPES ; Platelet diseases and coagulopathies ; PORCIN ; RECESSIVE GENES ; Reference Values ; SWINE ; Swine Diseases - genetics ; TRASTORNOS SANGUINEOS ; TROUBLE SANGUIN ; von Willebrand Diseases - blood ; von Willebrand Diseases - genetics ; von Willebrand Diseases - veterinary</subject><ispartof>The Journal of heredity, 1986-05, Vol.77 (3), p.179-182</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-1e020abb2884123af587f8da7b3fc80f71983f4d14434be8f4402bd4c2e60f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8771689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3488343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thiele, G.L</creatorcontrib><creatorcontrib>Rempel, W.E</creatorcontrib><creatorcontrib>Fass, D.N</creatorcontrib><creatorcontrib>Bowie, E.J.W</creatorcontrib><creatorcontrib>Stewart, M</creatorcontrib><creatorcontrib>Zoecklein, L</creatorcontrib><title>Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease</title><title>The Journal of heredity</title><addtitle>J Hered</addtitle><description>A herd of swine affected by Willebrand's disease was begun in 1967 at the Mayo Clinic in order to study the inherited hemostatic abnormality in swine as a model for the human disease. Affected individuals have bleeding times in excess of 15 minutes, extremely low levels of Willebrand factor (< 0.25 percent of normal), and decreased levels of VIII coagulant activity. Individuals with long bleeding times, higher levels of Willebrand factor and normal levels of VIII coagulant activity began to appear in the colony. It is hypothesized that this new (N) condition is inherited as a simple autosomal recessive (N/n) at a locus separate and independent of the similarly autosomal recessive (A/a) von Willebrand locus. In addition, the Willebrand locus is eplstatic to the N locus, i.e., individuals will only express the new condition provided there is at least one normal allele at the von Willebrand locus. Therefore, individuals with genotype aa—are all von Willebrand phenotyplcally, and A-nn individuals have the new disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BLOOD COAGULATION</subject><subject>BLOOD DISORDERS</subject><subject>CERDO</subject><subject>COAGULACION SANGUINEA</subject><subject>COAGULATION SANGUINE</subject><subject>Female</subject><subject>FENOTIPOS</subject><subject>GENE</subject><subject>GENE RECESSIF</subject><subject>GENES</subject><subject>GENES RECESIVOS</subject><subject>Genetic Carrier Screening</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemostasis</subject><subject>HEREDITE</subject><subject>HERENCIA</subject><subject>INHERITANCE</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pedigree</subject><subject>PHENOTYPE</subject><subject>PHENOTYPES</subject><subject>Platelet diseases and coagulopathies</subject><subject>PORCIN</subject><subject>RECESSIVE GENES</subject><subject>Reference Values</subject><subject>SWINE</subject><subject>Swine Diseases - genetics</subject><subject>TRASTORNOS SANGUINEOS</subject><subject>TROUBLE SANGUIN</subject><subject>von Willebrand Diseases - blood</subject><subject>von Willebrand Diseases - genetics</subject><subject>von Willebrand Diseases - veterinary</subject><issn>0022-1503</issn><issn>1465-7333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EKkPhB5CQsqCwymD7ObazYIFaYCoqFUERiI3lJM-th4zT2hlN-Xs8SlqJVVeWfM-7fjom5IjRJaM1vBtu3RC79bCNwfZpub7CiN3SMkY5Y4_IgglZlQoAHpMFpZyXrKLwlDxLaU0pZVVND8gBCK1BwIJ8Ow25wI82tFgMrrBFwF3R9IidD5dF5xPahIUPOclgt2fSzgcsdn68Kn76vscm2tC9TXfwc_LE5c3wxXwekotPHy-OV-XZ-efT4w9nZStAjSVDyqltGq61YBysq7RyurOqAddq6hSrNTjRMSFANKidEJQ3nWg5Suo4HJI3U-11HG62mEaz8anFvrcBh20yStYVl1A9CGZhktZyD76fwDYOKUV05jr6jY1_DaNm7978795M7s3sPs-_mh_aNpt8fzc9y8756zm3qbW9y9pan-4xrRSTus5YOWE-jXh7H9v4x0gFqjKrX7_NyclXqOQKzJfMv5x4ZwdjL2Ou_PFdq_zZVMI_ojuq5w</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Thiele, G.L</creator><creator>Rempel, W.E</creator><creator>Fass, D.N</creator><creator>Bowie, E.J.W</creator><creator>Stewart, M</creator><creator>Zoecklein, L</creator><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease</title><author>Thiele, G.L ; Rempel, W.E ; Fass, D.N ; Bowie, E.J.W ; Stewart, M ; Zoecklein, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-1e020abb2884123af587f8da7b3fc80f71983f4d14434be8f4402bd4c2e60f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BLOOD COAGULATION</topic><topic>BLOOD DISORDERS</topic><topic>CERDO</topic><topic>COAGULACION SANGUINEA</topic><topic>COAGULATION SANGUINE</topic><topic>Female</topic><topic>FENOTIPOS</topic><topic>GENE</topic><topic>GENE RECESSIF</topic><topic>GENES</topic><topic>GENES RECESIVOS</topic><topic>Genetic Carrier Screening</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemostasis</topic><topic>HEREDITE</topic><topic>HERENCIA</topic><topic>INHERITANCE</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pedigree</topic><topic>PHENOTYPE</topic><topic>PHENOTYPES</topic><topic>Platelet diseases and coagulopathies</topic><topic>PORCIN</topic><topic>RECESSIVE GENES</topic><topic>Reference Values</topic><topic>SWINE</topic><topic>Swine Diseases - genetics</topic><topic>TRASTORNOS SANGUINEOS</topic><topic>TROUBLE SANGUIN</topic><topic>von Willebrand Diseases - blood</topic><topic>von Willebrand Diseases - genetics</topic><topic>von Willebrand Diseases - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thiele, G.L</creatorcontrib><creatorcontrib>Rempel, W.E</creatorcontrib><creatorcontrib>Fass, D.N</creatorcontrib><creatorcontrib>Bowie, E.J.W</creatorcontrib><creatorcontrib>Stewart, M</creatorcontrib><creatorcontrib>Zoecklein, L</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thiele, G.L</au><au>Rempel, W.E</au><au>Fass, D.N</au><au>Bowie, E.J.W</au><au>Stewart, M</au><au>Zoecklein, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease</atitle><jtitle>The Journal of heredity</jtitle><addtitle>J Hered</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>77</volume><issue>3</issue><spage>179</spage><epage>182</epage><pages>179-182</pages><issn>0022-1503</issn><eissn>1465-7333</eissn><coden>JOHEA8</coden><abstract>A herd of swine affected by Willebrand's disease was begun in 1967 at the Mayo Clinic in order to study the inherited hemostatic abnormality in swine as a model for the human disease. Affected individuals have bleeding times in excess of 15 minutes, extremely low levels of Willebrand factor (< 0.25 percent of normal), and decreased levels of VIII coagulant activity. Individuals with long bleeding times, higher levels of Willebrand factor and normal levels of VIII coagulant activity began to appear in the colony. It is hypothesized that this new (N) condition is inherited as a simple autosomal recessive (N/n) at a locus separate and independent of the similarly autosomal recessive (A/a) von Willebrand locus. In addition, the Willebrand locus is eplstatic to the N locus, i.e., individuals will only express the new condition provided there is at least one normal allele at the von Willebrand locus. Therefore, individuals with genotype aa—are all von Willebrand phenotyplcally, and A-nn individuals have the new disease.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3488343</pmid><doi>10.1093/oxfordjournals.jhered.a110211</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1503 |
| ispartof | The Journal of heredity, 1986-05, Vol.77 (3), p.179-182 |
| issn | 0022-1503 1465-7333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76952635 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Biological and medical sciences BLOOD COAGULATION BLOOD DISORDERS CERDO COAGULACION SANGUINEA COAGULATION SANGUINE Female FENOTIPOS GENE GENE RECESSIF GENES GENES RECESIVOS Genetic Carrier Screening Hematologic and hematopoietic diseases Hemostasis HEREDITE HERENCIA INHERITANCE Male Medical sciences Pedigree PHENOTYPE PHENOTYPES Platelet diseases and coagulopathies PORCIN RECESSIVE GENES Reference Values SWINE Swine Diseases - genetics TRASTORNOS SANGUINEOS TROUBLE SANGUIN von Willebrand Diseases - blood von Willebrand Diseases - genetics von Willebrand Diseases - veterinary |
| title | Inheritance of a new bleeding disease in a herd of swine with Willebrand's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A30%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inheritance%20of%20a%20new%20bleeding%20disease%20in%20a%20herd%20of%20swine%20with%20Willebrand's%20disease&rft.jtitle=The%20Journal%20of%20heredity&rft.au=Thiele,%20G.L&rft.date=1986-05-01&rft.volume=77&rft.issue=3&rft.spage=179&rft.epage=182&rft.pages=179-182&rft.issn=0022-1503&rft.eissn=1465-7333&rft.coden=JOHEA8&rft_id=info:doi/10.1093/oxfordjournals.jhered.a110211&rft_dat=%3Cproquest_cross%3E14660965%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14660965&rft_id=info:pmid/3488343&rfr_iscdi=true |