Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages
Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry,...
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| Veröffentlicht in: | The Journal of infectious diseases 2001-03, Vol.183 (6), p.967-972 |
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| container_title | The Journal of infectious diseases |
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| creator | Tkachuk, Ariana N. Moormann, Ann M. Poore, Judy A. Rochford, Rosemary A. Chensue, Stephen W. Mwapasa, Victor Meshnick, Steven R. |
| description | Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5+ maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells |
| doi_str_mv | 10.1086/319248 |
| format | Article |
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The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5+ maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/319248</identifier><identifier>PMID: 11237815</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Biological and medical sciences ; CCR5 protein ; CD4 Antigens - biosynthesis ; CD4 Antigens - genetics ; Disease transmission ; Female ; Fetus - immunology ; Fluorescent Antibody Technique, Direct ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV 1 ; HIV Infections - transmission ; Human immunodeficiency virus ; Human protozoal diseases ; Humans ; Immunohistochemistry ; Infections ; Infectious diseases ; Lipopolysaccharide Receptors - biosynthesis ; Lipopolysaccharide Receptors - genetics ; Macrophages ; Macrophages - metabolism ; Major Articles ; Malaria ; Malaria - immunology ; Medical sciences ; Microbiology ; Parasitic diseases ; Placenta ; Placenta - immunology ; Plasmodium ; Plasmodium falciparum ; Pregnancy ; Pregnancy Complications, Parasitic - immunology ; Protozoal diseases ; Receptors ; Receptors, CCR5 - biosynthesis ; Receptors, CCR5 - genetics ; Receptors, CCR5 - immunology ; Receptors, Chemokine - biosynthesis ; Receptors, Chemokine - genetics ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; RNA ; RNA, Messenger - biosynthesis ; Transcriptional Activation ; Virology ; Women</subject><ispartof>The Journal of infectious diseases, 2001-03, Vol.183 (6), p.967-972</ispartof><rights>Copyright 2001 Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Mar 15, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-2b9b34cba67333d12a83b5ff912fad462eeda4e243e0ac283206467eda8a3bd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30110783$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30110783$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14156911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11237815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tkachuk, Ariana N.</creatorcontrib><creatorcontrib>Moormann, Ann M.</creatorcontrib><creatorcontrib>Poore, Judy A.</creatorcontrib><creatorcontrib>Rochford, Rosemary A.</creatorcontrib><creatorcontrib>Chensue, Stephen W.</creatorcontrib><creatorcontrib>Mwapasa, Victor</creatorcontrib><creatorcontrib>Meshnick, Steven R.</creatorcontrib><title>Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5+ maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells</description><subject>Biological and medical sciences</subject><subject>CCR5 protein</subject><subject>CD4 Antigens - biosynthesis</subject><subject>CD4 Antigens - genetics</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Fetus - immunology</subject><subject>Fluorescent Antibody Technique, Direct</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - transmission</subject><subject>Human immunodeficiency virus</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lipopolysaccharide Receptors - biosynthesis</subject><subject>Lipopolysaccharide Receptors - genetics</subject><subject>Macrophages</subject><subject>Macrophages - metabolism</subject><subject>Major Articles</subject><subject>Malaria</subject><subject>Malaria - immunology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Parasitic diseases</subject><subject>Placenta</subject><subject>Placenta - immunology</subject><subject>Plasmodium</subject><subject>Plasmodium falciparum</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - immunology</subject><subject>Protozoal diseases</subject><subject>Receptors</subject><subject>Receptors, CCR5 - biosynthesis</subject><subject>Receptors, CCR5 - genetics</subject><subject>Receptors, CCR5 - immunology</subject><subject>Receptors, Chemokine - biosynthesis</subject><subject>Receptors, Chemokine - genetics</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>RNA</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transcriptional Activation</subject><subject>Virology</subject><subject>Women</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0W1r1EAQB_BFFHtW_QZKFPRddHdnH5KXEk9PaGmpDxTfLJNk4uWaS-JuAvXbu5KjB4L4amH-P2aZGcaeCv5G8My8BZFLld1jK6HBpsYIuM9WnEuZiizPT9ijEHaccwXGPmQnQkiwmdArdnGOHfoWk3W_xb6ikKxvR08htEOfDE1SFEmxpf1w0_aUXFFF4zT4RCcxveywon7CLjnHyg_jFn9QeMweNNgFenJ4T9nXD-svxSY9u_j4qXh3llZa2SmVZV6Cqko0FgBqITGDUjdNLmSDtTKSqEZFUgFxrGQGkhtlbCxmCGUt4ZS9XvqOfvg5U5jcvg0VdR32NMzBWZNrqTn_LxQ250pxE-HLv-BumH0fh3BSQkRW6WO3OHAInho3-naP_pcT3P05hFsOEeHzQ7e53FN9ZIfNR_DqADBU2DU-br8NR6eENrkQ0b1Y3DCP__7s2WJ2IV7nTgEXgtsMYp4ueRsmur3L0d-4uH-r3eb6u_t2JTfvL6_BfYbfhSmv5g</recordid><startdate>20010315</startdate><enddate>20010315</enddate><creator>Tkachuk, Ariana N.</creator><creator>Moormann, Ann M.</creator><creator>Poore, Judy A.</creator><creator>Rochford, Rosemary A.</creator><creator>Chensue, Stephen W.</creator><creator>Mwapasa, Victor</creator><creator>Meshnick, Steven R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20010315</creationdate><title>Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages</title><author>Tkachuk, Ariana N. ; Moormann, Ann M. ; Poore, Judy A. ; Rochford, Rosemary A. ; Chensue, Stephen W. ; Mwapasa, Victor ; Meshnick, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-2b9b34cba67333d12a83b5ff912fad462eeda4e243e0ac283206467eda8a3bd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>CCR5 protein</topic><topic>CD4 Antigens - biosynthesis</topic><topic>CD4 Antigens - genetics</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Fetus - immunology</topic><topic>Fluorescent Antibody Technique, Direct</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - transmission</topic><topic>Human immunodeficiency virus</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lipopolysaccharide Receptors - biosynthesis</topic><topic>Lipopolysaccharide Receptors - genetics</topic><topic>Macrophages</topic><topic>Macrophages - metabolism</topic><topic>Major Articles</topic><topic>Malaria</topic><topic>Malaria - immunology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Parasitic diseases</topic><topic>Placenta</topic><topic>Placenta - immunology</topic><topic>Plasmodium</topic><topic>Plasmodium falciparum</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - immunology</topic><topic>Protozoal diseases</topic><topic>Receptors</topic><topic>Receptors, CCR5 - biosynthesis</topic><topic>Receptors, CCR5 - genetics</topic><topic>Receptors, CCR5 - immunology</topic><topic>Receptors, Chemokine - biosynthesis</topic><topic>Receptors, Chemokine - genetics</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>RNA</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transcriptional Activation</topic><topic>Virology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tkachuk, Ariana N.</creatorcontrib><creatorcontrib>Moormann, Ann M.</creatorcontrib><creatorcontrib>Poore, Judy A.</creatorcontrib><creatorcontrib>Rochford, Rosemary A.</creatorcontrib><creatorcontrib>Chensue, Stephen W.</creatorcontrib><creatorcontrib>Mwapasa, Victor</creatorcontrib><creatorcontrib>Meshnick, Steven R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tkachuk, Ariana N.</au><au>Moormann, Ann M.</au><au>Poore, Judy A.</au><au>Rochford, Rosemary A.</au><au>Chensue, Stephen W.</au><au>Mwapasa, Victor</au><au>Meshnick, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2001-03-15</date><risdate>2001</risdate><volume>183</volume><issue>6</issue><spage>967</spage><epage>972</epage><pages>967-972</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5+ maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11237815</pmid><doi>10.1086/319248</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2001-03, Vol.183 (6), p.967-972 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Biological and medical sciences CCR5 protein CD4 Antigens - biosynthesis CD4 Antigens - genetics Disease transmission Female Fetus - immunology Fluorescent Antibody Technique, Direct Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Infections - transmission Human immunodeficiency virus Human protozoal diseases Humans Immunohistochemistry Infections Infectious diseases Lipopolysaccharide Receptors - biosynthesis Lipopolysaccharide Receptors - genetics Macrophages Macrophages - metabolism Major Articles Malaria Malaria - immunology Medical sciences Microbiology Parasitic diseases Placenta Placenta - immunology Plasmodium Plasmodium falciparum Pregnancy Pregnancy Complications, Parasitic - immunology Protozoal diseases Receptors Receptors, CCR5 - biosynthesis Receptors, CCR5 - genetics Receptors, CCR5 - immunology Receptors, Chemokine - biosynthesis Receptors, Chemokine - genetics Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA RNA, Messenger - biosynthesis Transcriptional Activation Virology Women |
| title | Malaria Enhances Expression of CC Chemokine Receptor 5 on Placental Macrophages |
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