CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis
It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been...
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| Veröffentlicht in: | The Journal of pathology 2001-03, Vol.193 (3), p.383-389 |
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| container_title | The Journal of pathology |
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| creator | Faiz Kabir Uddin Ahmed, Abul Ohtani, Haruo Nio, Masaki Funaki, Nobuo Shimaoka, Satoru Nagura, Hiroshi Ohi, Ryoji |
| description | It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12–79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow‐up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/1096-9896(2000)9999:9999<::AID-PATH793>3.0.CO;2-O |
| format | Article |
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In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12–79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow‐up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period. Copyright © 2000 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH793>3.0.CO;2-O</identifier><identifier>PMID: 11241420</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Bile Ducts - immunology ; Bile Ducts - metabolism ; biliary atresia ; Biliary Atresia - immunology ; Biliary Atresia - metabolism ; Biological and medical sciences ; CD8 ; CD8-Positive T-Lymphocytes - immunology ; Child ; Child, Preschool ; Cytotoxicity, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Fas Ligand Protein ; FasL ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; granzyme B ; Granzymes ; Hepatocytes - pathology ; Humans ; Immunoenzyme Techniques ; Infant ; Infant, Newborn ; Ligands ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Malformations ; Medical sciences ; Membrane Glycoproteins - metabolism ; Microscopy, Fluorescence ; Middle Aged ; Perforin ; Pore Forming Cytotoxic Proteins ; Serine Endopeptidases - metabolism</subject><ispartof>The Journal of pathology, 2001-03, Vol.193 (3), p.383-389</ispartof><rights>Copyright © 2000 John Wiley & Sons, Ltd.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4243-43f501143b5581a0db6cfa804265eebd8c1eb1eaa06b32ef3679e3b4431e9e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH793%3E3.0.CO%3B2-O$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH793%3E3.0.CO%3B2-O$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=902767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11241420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faiz Kabir Uddin Ahmed, Abul</creatorcontrib><creatorcontrib>Ohtani, Haruo</creatorcontrib><creatorcontrib>Nio, Masaki</creatorcontrib><creatorcontrib>Funaki, Nobuo</creatorcontrib><creatorcontrib>Shimaoka, Satoru</creatorcontrib><creatorcontrib>Nagura, Hiroshi</creatorcontrib><creatorcontrib>Ohi, Ryoji</creatorcontrib><title>CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12–79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow‐up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Bile Ducts - immunology</subject><subject>Bile Ducts - metabolism</subject><subject>biliary atresia</subject><subject>Biliary Atresia - immunology</subject><subject>Biliary Atresia - metabolism</subject><subject>Biological and medical sciences</subject><subject>CD8</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytotoxicity, Immunologic</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fas Ligand Protein</subject><subject>FasL</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>granzyme B</subject><subject>Granzymes</subject><subject>Hepatocytes - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Ligands</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Malformations</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Microscopy, Fluorescence</subject><subject>Middle Aged</subject><subject>Perforin</subject><subject>Pore Forming Cytotoxic Proteins</subject><subject>Serine Endopeptidases - metabolism</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-KEzEUxgdR3Lr6ChIQxEWm5t9kJlUWale7C4tVqHp5OJNm1uh0Uicpbp_BlzZDu_XGC3Nxwkm-_M7J-bJMMzpmlPJXjGqV60qrF5xSeqbTmgzhzWQyvbrIP06Xl6UW52JMx7PFa54v7mWj45v72SgxeC4kK0-yRyF8Twyti-JhdsIYl0xyOsp-zy6ql2RJjG3bQFzXuDb2GF13k5LoSe1aS1ZbE4fLIXPY7wjG3gaHZOVJ5yPBzcZiT5K82XYmOt8RDMTsoo_-1pk7_IQgMa3rnPEbjN9862-cwZZgh-0uuPA4e9BgG-yTw36afX7_bjm7zK8X86vZ9Do3kkuRS9EUlDEp6qKoGNJVrUyDFZVcFdbWq8owWzOLSFUtuG2EKrUVtZSCWW1lKU6z53vupvc_tzZEWLswdIid9dsApdIFU5VKwk97oel9CL1tYNO7dRoAMAqDQzBMG4Zpw-AQDObsA0ByCA4OgQAKswVwWCTm00Pxbb22q7_EgyVJ8OwgwJCm0_TYGReOOk15qYY_LPeqX8mg3f_39e-u7o4SNt9jXYj29ojF_gekomUBXz_MQb2VX9RccCjFH-1Exuk</recordid><startdate>200103</startdate><enddate>200103</enddate><creator>Faiz Kabir Uddin Ahmed, Abul</creator><creator>Ohtani, Haruo</creator><creator>Nio, Masaki</creator><creator>Funaki, Nobuo</creator><creator>Shimaoka, Satoru</creator><creator>Nagura, Hiroshi</creator><creator>Ohi, Ryoji</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200103</creationdate><title>CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis</title><author>Faiz Kabir Uddin Ahmed, Abul ; Ohtani, Haruo ; Nio, Masaki ; Funaki, Nobuo ; Shimaoka, Satoru ; Nagura, Hiroshi ; Ohi, Ryoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4243-43f501143b5581a0db6cfa804265eebd8c1eb1eaa06b32ef3679e3b4431e9e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Bile Ducts - immunology</topic><topic>Bile Ducts - metabolism</topic><topic>biliary atresia</topic><topic>Biliary Atresia - immunology</topic><topic>Biliary Atresia - metabolism</topic><topic>Biological and medical sciences</topic><topic>CD8</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytotoxicity, Immunologic</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fas Ligand Protein</topic><topic>FasL</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>granzyme B</topic><topic>Granzymes</topic><topic>Hepatocytes - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Ligands</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Malformations</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Microscopy, Fluorescence</topic><topic>Middle Aged</topic><topic>Perforin</topic><topic>Pore Forming Cytotoxic Proteins</topic><topic>Serine Endopeptidases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faiz Kabir Uddin Ahmed, Abul</creatorcontrib><creatorcontrib>Ohtani, Haruo</creatorcontrib><creatorcontrib>Nio, Masaki</creatorcontrib><creatorcontrib>Funaki, Nobuo</creatorcontrib><creatorcontrib>Shimaoka, Satoru</creatorcontrib><creatorcontrib>Nagura, Hiroshi</creatorcontrib><creatorcontrib>Ohi, Ryoji</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faiz Kabir Uddin Ahmed, Abul</au><au>Ohtani, Haruo</au><au>Nio, Masaki</au><au>Funaki, Nobuo</au><au>Shimaoka, Satoru</au><au>Nagura, Hiroshi</au><au>Ohi, Ryoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2001-03</date><risdate>2001</risdate><volume>193</volume><issue>3</issue><spage>383</spage><epage>389</epage><pages>383-389</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12–79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow‐up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11241420</pmid><doi>10.1002/1096-9896(2000)9999:9999<::AID-PATH793>3.0.CO;2-O</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Bile Ducts - immunology Bile Ducts - metabolism biliary atresia Biliary Atresia - immunology Biliary Atresia - metabolism Biological and medical sciences CD8 CD8-Positive T-Lymphocytes - immunology Child Child, Preschool Cytotoxicity, Immunologic Enzyme-Linked Immunosorbent Assay Fas Ligand Protein FasL Female Gastroenterology. Liver. Pancreas. Abdomen granzyme B Granzymes Hepatocytes - pathology Humans Immunoenzyme Techniques Infant Infant, Newborn Ligands Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Malformations Medical sciences Membrane Glycoproteins - metabolism Microscopy, Fluorescence Middle Aged Perforin Pore Forming Cytotoxic Proteins Serine Endopeptidases - metabolism |
| title | CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis |
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