Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine
Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2001-04, Vol.183 (7), p.1116-1120 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1120 |
|---|---|
| container_issue | 7 |
| container_start_page | 1116 |
| container_title | The Journal of infectious diseases |
| container_volume | 183 |
| creator | Jankelevich, Shirley Mueller, Brigitta U. Mackall, Crystal L. Smith, Sharon Zwerski, Sheryl Wood, Lauren V. Zeichner, Steven L. Serchuck, Leslie Steinberg, Seth M. Nelson, Robert P. Sleasman, John W. Nguyen, Bach-Yen Pizzo, Philip A. Yarchoan, Robert |
| description | Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/μL and a median decrease of 0.74 log10 HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+ T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ⩾0.7 log10 HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+ T cell counts. CD4+CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression |
| doi_str_mv | 10.1086/319274 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76951159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30111171</jstor_id><oup_id>10.1086/319274</oup_id><sourcerecordid>30111171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-274db3299ca16a84734e16939497d67b77a32821d61401044cef3baf1544bf473</originalsourceid><addsrcrecordid>eNqFkdFu0zAUhi0EYqXAG4A8JLhawCd24vgSOqCVKiGNgqbdWG7ibC6JHexk0EfhbXFJtEpICN9Yx__n_-icH6GnQF4DKfI3FETK2T00g4zyJM-B3kczQtI0gUKIE_QohB0hhNGcP0QnACnlBRUz9Gvt7HXSa9_ir8a7xl2bEitb4VXbDnaqL3TonA06YGPxcmiVneRK16Y02pb7w-8h4M2-0xiSla112esKL25MU3lt8cZrdXj4YfobvLKVserW-DN8ZSp3O8RSn_1pu1atGevH6EGtmqCfTPccffnwfrNYJutPH1eLt-ukZAX0SZy62tJUiFJBrgrGKdOQCyqY4FXOt5wrmhYpVDkwAoSxUtd0q2rIGNvWEZ-jV6Nv5933QYdetiaUummU1W4IkuciA8jEf0HgcdNFXPEcvfgL3LnB2ziETFMqYlwpO7qV3oXgdS07b1rl9xKIPEQqx0gj-HxyG7atro7YlGEEXk6ACqVqaq9sacKRY5DlIj1wpyPnhu7fzZ6NzC70zt9RlEA8HKKejLoJvf55pyv_Teac8kwuL6_kZ3rx7vxys5Tn9DcLo8qO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223908624</pqid></control><display><type>article</type><title>Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Jankelevich, Shirley ; Mueller, Brigitta U. ; Mackall, Crystal L. ; Smith, Sharon ; Zwerski, Sheryl ; Wood, Lauren V. ; Zeichner, Steven L. ; Serchuck, Leslie ; Steinberg, Seth M. ; Nelson, Robert P. ; Sleasman, John W. ; Nguyen, Bach-Yen ; Pizzo, Philip A. ; Yarchoan, Robert</creator><creatorcontrib>Jankelevich, Shirley ; Mueller, Brigitta U. ; Mackall, Crystal L. ; Smith, Sharon ; Zwerski, Sheryl ; Wood, Lauren V. ; Zeichner, Steven L. ; Serchuck, Leslie ; Steinberg, Seth M. ; Nelson, Robert P. ; Sleasman, John W. ; Nguyen, Bach-Yen ; Pizzo, Philip A. ; Yarchoan, Robert</creatorcontrib><description>Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/μL and a median decrease of 0.74 log10 HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+ T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ⩾0.7 log10 HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+ T cell counts. CD4+CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/319274</identifier><identifier>PMID: 11237839</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; AIDS ; Anti-HIV Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; CD4 antigen ; CD4 Antigens - analysis ; CD4 Lymphocyte Count ; Child ; Child health services ; Child, Preschool ; Concise Communications ; Dosage ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; HIV ; HIV - isolation & purification ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV Protease Inhibitors - therapeutic use ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunology ; Indinavir ; Indinavir - therapeutic use ; Infectious diseases ; Lamivudine ; Lamivudine - therapeutic use ; Leukocyte Common Antigens - analysis ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Protease inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; RNA ; RNA, Viral - analysis ; T lymphocytes ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology ; Viruses ; Zidovudine ; Zidovudine - therapeutic use</subject><ispartof>The Journal of infectious diseases, 2001-04, Vol.183 (7), p.1116-1120</ispartof><rights>Copyright 2001 Infectious Diseases Society of America</rights><rights>2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 1, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-274db3299ca16a84734e16939497d67b77a32821d61401044cef3baf1544bf473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111171$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111171$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14156929$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11237839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jankelevich, Shirley</creatorcontrib><creatorcontrib>Mueller, Brigitta U.</creatorcontrib><creatorcontrib>Mackall, Crystal L.</creatorcontrib><creatorcontrib>Smith, Sharon</creatorcontrib><creatorcontrib>Zwerski, Sheryl</creatorcontrib><creatorcontrib>Wood, Lauren V.</creatorcontrib><creatorcontrib>Zeichner, Steven L.</creatorcontrib><creatorcontrib>Serchuck, Leslie</creatorcontrib><creatorcontrib>Steinberg, Seth M.</creatorcontrib><creatorcontrib>Nelson, Robert P.</creatorcontrib><creatorcontrib>Sleasman, John W.</creatorcontrib><creatorcontrib>Nguyen, Bach-Yen</creatorcontrib><creatorcontrib>Pizzo, Philip A.</creatorcontrib><creatorcontrib>Yarchoan, Robert</creatorcontrib><title>Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/μL and a median decrease of 0.74 log10 HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+ T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ⩾0.7 log10 HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+ T cell counts. CD4+CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression</description><subject>Adolescent</subject><subject>AIDS</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>CD4 Antigens - analysis</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Child health services</subject><subject>Child, Preschool</subject><subject>Concise Communications</subject><subject>Dosage</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HIV</subject><subject>HIV - isolation & purification</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV Protease Inhibitors - therapeutic use</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunology</subject><subject>Indinavir</subject><subject>Indinavir - therapeutic use</subject><subject>Infectious diseases</subject><subject>Lamivudine</subject><subject>Lamivudine - therapeutic use</subject><subject>Leukocyte Common Antigens - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Protease inhibitors</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 1</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><subject>Zidovudine</subject><subject>Zidovudine - therapeutic use</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFu0zAUhi0EYqXAG4A8JLhawCd24vgSOqCVKiGNgqbdWG7ibC6JHexk0EfhbXFJtEpICN9Yx__n_-icH6GnQF4DKfI3FETK2T00g4zyJM-B3kczQtI0gUKIE_QohB0hhNGcP0QnACnlBRUz9Gvt7HXSa9_ir8a7xl2bEitb4VXbDnaqL3TonA06YGPxcmiVneRK16Y02pb7w-8h4M2-0xiSla112esKL25MU3lt8cZrdXj4YfobvLKVserW-DN8ZSp3O8RSn_1pu1atGevH6EGtmqCfTPccffnwfrNYJutPH1eLt-ukZAX0SZy62tJUiFJBrgrGKdOQCyqY4FXOt5wrmhYpVDkwAoSxUtd0q2rIGNvWEZ-jV6Nv5933QYdetiaUummU1W4IkuciA8jEf0HgcdNFXPEcvfgL3LnB2ziETFMqYlwpO7qV3oXgdS07b1rl9xKIPEQqx0gj-HxyG7atro7YlGEEXk6ACqVqaq9sacKRY5DlIj1wpyPnhu7fzZ6NzC70zt9RlEA8HKKejLoJvf55pyv_Teac8kwuL6_kZ3rx7vxys5Tn9DcLo8qO</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Jankelevich, Shirley</creator><creator>Mueller, Brigitta U.</creator><creator>Mackall, Crystal L.</creator><creator>Smith, Sharon</creator><creator>Zwerski, Sheryl</creator><creator>Wood, Lauren V.</creator><creator>Zeichner, Steven L.</creator><creator>Serchuck, Leslie</creator><creator>Steinberg, Seth M.</creator><creator>Nelson, Robert P.</creator><creator>Sleasman, John W.</creator><creator>Nguyen, Bach-Yen</creator><creator>Pizzo, Philip A.</creator><creator>Yarchoan, Robert</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine</title><author>Jankelevich, Shirley ; Mueller, Brigitta U. ; Mackall, Crystal L. ; Smith, Sharon ; Zwerski, Sheryl ; Wood, Lauren V. ; Zeichner, Steven L. ; Serchuck, Leslie ; Steinberg, Seth M. ; Nelson, Robert P. ; Sleasman, John W. ; Nguyen, Bach-Yen ; Pizzo, Philip A. ; Yarchoan, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-274db3299ca16a84734e16939497d67b77a32821d61401044cef3baf1544bf473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>AIDS</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen</topic><topic>CD4 Antigens - analysis</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Child health services</topic><topic>Child, Preschool</topic><topic>Concise Communications</topic><topic>Dosage</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HIV</topic><topic>HIV - isolation & purification</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV Protease Inhibitors - therapeutic use</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunology</topic><topic>Indinavir</topic><topic>Indinavir - therapeutic use</topic><topic>Infectious diseases</topic><topic>Lamivudine</topic><topic>Lamivudine - therapeutic use</topic><topic>Leukocyte Common Antigens - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Protease inhibitors</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 1</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virology</topic><topic>Viruses</topic><topic>Zidovudine</topic><topic>Zidovudine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jankelevich, Shirley</creatorcontrib><creatorcontrib>Mueller, Brigitta U.</creatorcontrib><creatorcontrib>Mackall, Crystal L.</creatorcontrib><creatorcontrib>Smith, Sharon</creatorcontrib><creatorcontrib>Zwerski, Sheryl</creatorcontrib><creatorcontrib>Wood, Lauren V.</creatorcontrib><creatorcontrib>Zeichner, Steven L.</creatorcontrib><creatorcontrib>Serchuck, Leslie</creatorcontrib><creatorcontrib>Steinberg, Seth M.</creatorcontrib><creatorcontrib>Nelson, Robert P.</creatorcontrib><creatorcontrib>Sleasman, John W.</creatorcontrib><creatorcontrib>Nguyen, Bach-Yen</creatorcontrib><creatorcontrib>Pizzo, Philip A.</creatorcontrib><creatorcontrib>Yarchoan, Robert</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jankelevich, Shirley</au><au>Mueller, Brigitta U.</au><au>Mackall, Crystal L.</au><au>Smith, Sharon</au><au>Zwerski, Sheryl</au><au>Wood, Lauren V.</au><au>Zeichner, Steven L.</au><au>Serchuck, Leslie</au><au>Steinberg, Seth M.</au><au>Nelson, Robert P.</au><au>Sleasman, John W.</au><au>Nguyen, Bach-Yen</au><au>Pizzo, Philip A.</au><au>Yarchoan, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>183</volume><issue>7</issue><spage>1116</spage><epage>1120</epage><pages>1116-1120</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/μL and a median decrease of 0.74 log10 HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+ T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ⩾0.7 log10 HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+ T cell counts. CD4+CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11237839</pmid><doi>10.1086/319274</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2001-04, Vol.183 (7), p.1116-1120 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76951159 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent AIDS Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 antigen CD4 Antigens - analysis CD4 Lymphocyte Count Child Child health services Child, Preschool Concise Communications Dosage Drug Therapy, Combination Female Follow-Up Studies HIV HIV - isolation & purification HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Protease Inhibitors - therapeutic use Human immunodeficiency virus 1 Human viral diseases Humans Immunology Indinavir Indinavir - therapeutic use Infectious diseases Lamivudine Lamivudine - therapeutic use Leukocyte Common Antigens - analysis Male Medical sciences Pharmacology. Drug treatments Protease inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 RNA RNA, Viral - analysis T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology Viruses Zidovudine Zidovudine - therapeutic use |
| title | Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A59%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20Virologic%20and%20Immunologic%20Responses%20in%20Human%20Immunodeficiency%20Virus%20Type%201-Infected%20Children%20Treated%20with%20Indinavir,%20Zidovudine,%20and%20Lamivudine&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Jankelevich,%20Shirley&rft.date=2001-04-01&rft.volume=183&rft.issue=7&rft.spage=1116&rft.epage=1120&rft.pages=1116-1120&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/319274&rft_dat=%3Cjstor_proqu%3E30111171%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223908624&rft_id=info:pmid/11237839&rft_jstor_id=30111171&rft_oup_id=10.1086/319274&rfr_iscdi=true |