Detection of the Low Molecular Weight Heparin Component of ITF 1300 in Urines After Intranasal Administration to Dogs
GAGs were purified from urine of dogs after intranasal administration of 40 mg/kg ITF 1300. The electrophoretic patterns of urine GAGs in acidic buffer showed the presence of heparin together with chondroitins, heparan sulfate, and hyaluronic acid. The heparin present in urines was purified using ch...
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| Veröffentlicht in: | Seminars in thrombosis and hemostasis 1994-01, Vol.20 (3), p.293-296 |
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| container_title | Seminars in thrombosis and hemostasis |
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| creator | Oreste, Pasqua Stella, Patrizia Zoppetti, Giorgio |
| description | GAGs were purified from urine of dogs after intranasal administration of 40 mg/kg ITF 1300. The electrophoretic patterns of urine GAGs in acidic buffer showed the presence of heparin together with chondroitins, heparan sulfate, and hyaluronic acid. The heparin present in urines was purified using chondroitinase ABC, and its purity was tested by electrophoresis in acidic buffer. The sample obtained was characterized by 13C-NMR, showing the same characteristic signals of the heparin starting material. |
| doi_str_mv | 10.1055/s-2007-1001915 |
| format | Article |
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The electrophoretic patterns of urine GAGs in acidic buffer showed the presence of heparin together with chondroitins, heparan sulfate, and hyaluronic acid. The heparin present in urines was purified using chondroitinase ABC, and its purity was tested by electrophoresis in acidic buffer. The sample obtained was characterized by 13C-NMR, showing the same characteristic signals of the heparin starting material.</description><identifier>ISSN: 0094-6176</identifier><identifier>EISSN: 1098-9064</identifier><identifier>DOI: 10.1055/s-2007-1001915</identifier><identifier>PMID: 7824964</identifier><identifier>CODEN: STHMBV</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Administration, Intranasal ; Animals ; Biological and medical sciences ; Blood. Blood coagulation. 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The electrophoretic patterns of urine GAGs in acidic buffer showed the presence of heparin together with chondroitins, heparan sulfate, and hyaluronic acid. The heparin present in urines was purified using chondroitinase ABC, and its purity was tested by electrophoresis in acidic buffer. The sample obtained was characterized by 13C-NMR, showing the same characteristic signals of the heparin starting material.</description><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Chemical Precipitation</subject><subject>Dogs</subject><subject>Glycosaminoglycans - urine</subject><subject>Heparin, Low-Molecular-Weight - isolation & purification</subject><subject>Heparin, Low-Molecular-Weight - urine</subject><subject>Medical sciences</subject><subject>Pharmacology. 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The electrophoretic patterns of urine GAGs in acidic buffer showed the presence of heparin together with chondroitins, heparan sulfate, and hyaluronic acid. The heparin present in urines was purified using chondroitinase ABC, and its purity was tested by electrophoresis in acidic buffer. The sample obtained was characterized by 13C-NMR, showing the same characteristic signals of the heparin starting material.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>7824964</pmid><doi>10.1055/s-2007-1001915</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0094-6176 |
| ispartof | Seminars in thrombosis and hemostasis, 1994-01, Vol.20 (3), p.293-296 |
| issn | 0094-6176 1098-9064 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Administration, Intranasal Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Chemical Precipitation Dogs Glycosaminoglycans - urine Heparin, Low-Molecular-Weight - isolation & purification Heparin, Low-Molecular-Weight - urine Medical sciences Pharmacology. Drug treatments |
| title | Detection of the Low Molecular Weight Heparin Component of ITF 1300 in Urines After Intranasal Administration to Dogs |
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