Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo
A prospective randomized placebo controlled double-blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty-two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 1986-04, Vol.24 (2), p.157-160 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Hakim, M. Gonen, R. Levitan, Z. Sharf, M. |
| description | A prospective randomized placebo controlled double-blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty-two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses of 1 g mezlocillin and 53 patients received placebo.
Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups.
It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs - cefazolin and mezlocillin - seem to be equally effective. |
| doi_str_mv | 10.1016/0020-7292(86)90011-1 |
| format | Article |
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Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups.
It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs - cefazolin and mezlocillin - seem to be equally effective.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/0020-7292(86)90011-1</identifier><identifier>PMID: 2874085</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cefazolin - therapeutic use ; Cellulitis - prevention & control ; Clinical Trials as Topic ; Double-Blind Method ; Elective abdominal hysterectomy ; Evaluate effect of antibiotic prophylaxis ; Female ; Humans ; Hysterectomy ; Medical sciences ; Mezlocillin - therapeutic use ; Middle Aged ; Pharmacology. Drug treatments ; Placebo controlled double blind study ; Postoperative Complications - prevention & control ; Postoperative infectious morbidity ; Premedication ; Random Allocation ; Rate of pelvic cellulitis ; Surgical Wound Infection - prevention & control ; Time Factors ; Urinary Tract Infections - prevention & control</subject><ispartof>International journal of gynecology and obstetrics, 1986-04, Vol.24 (2), p.157-160</ispartof><rights>1986</rights><rights>1986 International Federation of Gynecology and Obstetrics</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4367-4adba34ead4e5e2060c862d8db48fcb68444d85be813e0d66bf4b67f39193c213</citedby><cites>FETCH-LOGICAL-c4367-4adba34ead4e5e2060c862d8db48fcb68444d85be813e0d66bf4b67f39193c213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2F0020-7292%2886%2990011-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/0020-7292(86)90011-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,1417,3550,27924,27925,45574,45575,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7953720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2874085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakim, M.</creatorcontrib><creatorcontrib>Gonen, R.</creatorcontrib><creatorcontrib>Levitan, Z.</creatorcontrib><creatorcontrib>Sharf, M.</creatorcontrib><title>Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>A prospective randomized placebo controlled double-blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty-two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses of 1 g mezlocillin and 53 patients received placebo.
Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups.
It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs - cefazolin and mezlocillin - seem to be equally effective.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cefazolin - therapeutic use</subject><subject>Cellulitis - prevention & control</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Elective abdominal hysterectomy</subject><subject>Evaluate effect of antibiotic prophylaxis</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Medical sciences</subject><subject>Mezlocillin - therapeutic use</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebo controlled double blind study</subject><subject>Postoperative Complications - prevention & control</subject><subject>Postoperative infectious morbidity</subject><subject>Premedication</subject><subject>Random Allocation</subject><subject>Rate of pelvic cellulitis</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Time Factors</subject><subject>Urinary Tract Infections - prevention & control</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd2KFDEQhRtR1nH1DRRyIaJga9Kdzs9eCDrourKwN3od8lPNRNKdNulZ7X0En9q0M8yleJUi9Z0q6pyqekrwG4IJe4txg2veyOalYK8kxoTU5F61IYLLuqVc3q82J-Rh9Sjn77hAnJCz6qwRnGLRbarfH1LUDuUJ7Jz2A9Lj7I2Ps7cZ6YzyLqYZzZAGNKU47Zagf_mM-pgQhCLxt4C0cXHwow5ot-SClu84LBdoG4dJJ5_jiGKPBrgL0foQ_PgaWej1XSxl2efQFLQFEx9XD3odMjw5vufVt08fv24_19c3l1fb99e1pS3jNdXO6JaCdhQ6aDDDVrDGCWeo6K1hglLqRGdAkBawY8z01DDet5LI1jakPa9eHOaWi37sIc9q8NlCCHqEuM-KM0kl5itID6BNMecEvZqSH3RaFMFqjUCt_qrVXyWY-huBWmXPjvP3ZgB3Eh09L_3nx77OVoc-6dH6fMK47Fre4ILJA_bTB1j-a7W6-nJ5QzpetO8OWig-3npIKlsPowXn13iUi_7fN_wBi7e2Jw</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>Hakim, M.</creator><creator>Gonen, R.</creator><creator>Levitan, Z.</creator><creator>Sharf, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo</title><author>Hakim, M. ; Gonen, R. ; Levitan, Z. ; Sharf, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4367-4adba34ead4e5e2060c862d8db48fcb68444d85be813e0d66bf4b67f39193c213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cefazolin - therapeutic use</topic><topic>Cellulitis - prevention & control</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Elective abdominal hysterectomy</topic><topic>Evaluate effect of antibiotic prophylaxis</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Medical sciences</topic><topic>Mezlocillin - therapeutic use</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebo controlled double blind study</topic><topic>Postoperative Complications - prevention & control</topic><topic>Postoperative infectious morbidity</topic><topic>Premedication</topic><topic>Random Allocation</topic><topic>Rate of pelvic cellulitis</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Time Factors</topic><topic>Urinary Tract Infections - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakim, M.</creatorcontrib><creatorcontrib>Gonen, R.</creatorcontrib><creatorcontrib>Levitan, Z.</creatorcontrib><creatorcontrib>Sharf, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakim, M.</au><au>Gonen, R.</au><au>Levitan, Z.</au><au>Sharf, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>1986-04</date><risdate>1986</risdate><volume>24</volume><issue>2</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>A prospective randomized placebo controlled double-blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty-two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses of 1 g mezlocillin and 53 patients received placebo.
Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups.
It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs - cefazolin and mezlocillin - seem to be equally effective.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2874085</pmid><doi>10.1016/0020-7292(86)90011-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 1986-04, Vol.24 (2), p.157-160 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| source | MEDLINE; Wiley Online Library; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefazolin - therapeutic use Cellulitis - prevention & control Clinical Trials as Topic Double-Blind Method Elective abdominal hysterectomy Evaluate effect of antibiotic prophylaxis Female Humans Hysterectomy Medical sciences Mezlocillin - therapeutic use Middle Aged Pharmacology. Drug treatments Placebo controlled double blind study Postoperative Complications - prevention & control Postoperative infectious morbidity Premedication Random Allocation Rate of pelvic cellulitis Surgical Wound Infection - prevention & control Time Factors Urinary Tract Infections - prevention & control |
| title | Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo |
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