Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension
. Žižek B, Poredoš P (University Medical Centre, Ljubljana, Slovenia). Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. J Intern Med 2001; 249: 189–197. Objectives. To evaluate whether endothelium‐depen...
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| description | . Žižek B, Poredoš P (University Medical Centre, Ljubljana, Slovenia). Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. J Intern Med 2001; 249: 189–197.
Objectives. To evaluate whether endothelium‐dependent (nitric oxide‐mediated) dilation of the brachial artery (BA) is impaired in patients being treated for essential hypertension (EH), and whether this abnormality can be detected in normotensive offspring of subjects with EH (familial trait, FT); and to investigate the interrelationship between flow‐mediated vasodilation (FMD) and hyperinsulinaemia/insulin resistance.
Design. Cross‐sectional study.
Setting. Angiology department at a teaching hospital.
Subjects. The study encompassed 172 subjects, of whom 46 were treated hypertonics aged 40–55 (49) years, and 44 age‐matched, normotensive volunteers as controls. We also investigated 41 normotonics with FT aged 20–30 (25) years and 41 age‐and sex‐matched controls without FT.
Main outcome measures. Using high‐resolution ultrasound, BA diameters at rest, during reactive hyperaemia (endothelium‐dependent dilation) and after sublingual glyceryl trinitrate (GTN) application (endothelium‐independent dilation) were measured.
Results. In hypertonics FMD was significantly lower than in controls [2.4 (2.9) vs. 7.4 (2.5)%; P |
| doi_str_mv | 10.1046/j.1365-2796.2001.00794.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76948913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76948913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4204-684024f344393ae3299f4c898fc03babb7dc2bd5e3fc9d27c045aa47a4df5f043</originalsourceid><addsrcrecordid>eNqNkctuFDEQRS0EIkPgF5AFErtp_OqHFyxQRGBQUDawttx-MG712IOrO8l8Rv4YNzMkEitWLqlOXVfpIIQpqSgRzfuhoryp16yVTcUIoRUhrRTV3RO0emg8RSsia7FuOkbO0AuAoYCcNOQ5OqOUCdIJuUL3mwjzGCLODgJMOhqHtbWAp4RdtGnaujHoEdsD-DmaKaSIC7097F2eXIRw4_BeT8HFCbCOdmnGlHfpbzN5D_sc4s9SYZj7wZlC3oZpix1AGVvSH-NSfImeeT2Ce3V6z9GPy0_fL76sr64_by4-Xq2NYGQ5SxAmPBeCS64dZ1J6YTrZeUN4r_u-tYb1tnbcG2lZa4iotRatFtbXngh-jt4dc_c5_ZodTGoXwLhx1NGlGVTbSNFJygv45h9wSHOOZTdFZSs5awUtUHeETE4A2XlVjt7pfFCUqMWZGtSiRi1q1OJM_XGm7sro61P-3O-cfRw8SSrA2xOgwejR52IpwAPXdbLhrFAfjtRtGN3hv79XX68330rFfwPffrY6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197932741</pqid></control><display><type>article</type><title>Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>ZIZEK, B ; POREDOS, P</creator><creatorcontrib>ZIZEK, B ; POREDOS, P</creatorcontrib><description>. Žižek B, Poredoš P (University Medical Centre, Ljubljana, Slovenia). Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. J Intern Med 2001; 249: 189–197.
Objectives. To evaluate whether endothelium‐dependent (nitric oxide‐mediated) dilation of the brachial artery (BA) is impaired in patients being treated for essential hypertension (EH), and whether this abnormality can be detected in normotensive offspring of subjects with EH (familial trait, FT); and to investigate the interrelationship between flow‐mediated vasodilation (FMD) and hyperinsulinaemia/insulin resistance.
Design. Cross‐sectional study.
Setting. Angiology department at a teaching hospital.
Subjects. The study encompassed 172 subjects, of whom 46 were treated hypertonics aged 40–55 (49) years, and 44 age‐matched, normotensive volunteers as controls. We also investigated 41 normotonics with FT aged 20–30 (25) years and 41 age‐and sex‐matched controls without FT.
Main outcome measures. Using high‐resolution ultrasound, BA diameters at rest, during reactive hyperaemia (endothelium‐dependent dilation) and after sublingual glyceryl trinitrate (GTN) application (endothelium‐independent dilation) were measured.
Results. In hypertonics FMD was significantly lower than in controls [2.4 (2.9) vs. 7.4 (2.5)%; P < 0.00005], as was GTN‐induced dilation [12.1 (4.3) vs. 16.1 (4.6)%; P=0.0007]. In subjects with FT, FMD was also decreased compared with the control group [5.8 (4.1) vs. 10.0 (3.0)%; P < 0.00005]. The response to GTN was comparable in both groups of young subjects. FMD was negatively related to insulin concentration in all subjects studied (P < 0.00005).
Conclusions. In treated patients with EH, flow‐mediated dilation of the BA as well as endothelium‐independent dilation are decreased. In individuals with FT the endothelial function of the peripheral arteries is also altered in the absence of elevated blood pressure. Endothelial dysfunction is related to hyperinsulinaemia/insulin resistance, which could be one of the pathogenetic determinants of EH and its complications.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1046/j.1365-2796.2001.00794.x</identifier><identifier>PMID: 11240849</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Cardiovascular system ; Cross-Sectional Studies ; dilation of conduit arteries ; endothelial dysfunction ; essential hypertension ; Female ; Hemodynamics ; Humans ; hyperinsulinaemia ; Hyperinsulinism - physiopathology ; Hypertension - drug therapy ; Hypertension - genetics ; Hypertension - physiopathology ; Insulin resistance ; Investigative techniques, diagnostic techniques (general aspects) ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Nitric Oxide - physiology ; Ultrasonic investigative techniques ; Ultrasonography ; Vasodilation</subject><ispartof>Journal of internal medicine, 2001-02, Vol.249 (2), p.189-197</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Feb 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4204-684024f344393ae3299f4c898fc03babb7dc2bd5e3fc9d27c045aa47a4df5f043</citedby><cites>FETCH-LOGICAL-c4204-684024f344393ae3299f4c898fc03babb7dc2bd5e3fc9d27c045aa47a4df5f043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2796.2001.00794.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2796.2001.00794.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=889632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11240849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZIZEK, B</creatorcontrib><creatorcontrib>POREDOS, P</creatorcontrib><title>Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Žižek B, Poredoš P (University Medical Centre, Ljubljana, Slovenia). Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. J Intern Med 2001; 249: 189–197.
Objectives. To evaluate whether endothelium‐dependent (nitric oxide‐mediated) dilation of the brachial artery (BA) is impaired in patients being treated for essential hypertension (EH), and whether this abnormality can be detected in normotensive offspring of subjects with EH (familial trait, FT); and to investigate the interrelationship between flow‐mediated vasodilation (FMD) and hyperinsulinaemia/insulin resistance.
Design. Cross‐sectional study.
Setting. Angiology department at a teaching hospital.
Subjects. The study encompassed 172 subjects, of whom 46 were treated hypertonics aged 40–55 (49) years, and 44 age‐matched, normotensive volunteers as controls. We also investigated 41 normotonics with FT aged 20–30 (25) years and 41 age‐and sex‐matched controls without FT.
Main outcome measures. Using high‐resolution ultrasound, BA diameters at rest, during reactive hyperaemia (endothelium‐dependent dilation) and after sublingual glyceryl trinitrate (GTN) application (endothelium‐independent dilation) were measured.
Results. In hypertonics FMD was significantly lower than in controls [2.4 (2.9) vs. 7.4 (2.5)%; P < 0.00005], as was GTN‐induced dilation [12.1 (4.3) vs. 16.1 (4.6)%; P=0.0007]. In subjects with FT, FMD was also decreased compared with the control group [5.8 (4.1) vs. 10.0 (3.0)%; P < 0.00005]. The response to GTN was comparable in both groups of young subjects. FMD was negatively related to insulin concentration in all subjects studied (P < 0.00005).
Conclusions. In treated patients with EH, flow‐mediated dilation of the BA as well as endothelium‐independent dilation are decreased. In individuals with FT the endothelial function of the peripheral arteries is also altered in the absence of elevated blood pressure. Endothelial dysfunction is related to hyperinsulinaemia/insulin resistance, which could be one of the pathogenetic determinants of EH and its complications.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiovascular system</subject><subject>Cross-Sectional Studies</subject><subject>dilation of conduit arteries</subject><subject>endothelial dysfunction</subject><subject>essential hypertension</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>hyperinsulinaemia</subject><subject>Hyperinsulinism - physiopathology</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Insulin resistance</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric Oxide - physiology</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><subject>Vasodilation</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctuFDEQRS0EIkPgF5AFErtp_OqHFyxQRGBQUDawttx-MG712IOrO8l8Rv4YNzMkEitWLqlOXVfpIIQpqSgRzfuhoryp16yVTcUIoRUhrRTV3RO0emg8RSsia7FuOkbO0AuAoYCcNOQ5OqOUCdIJuUL3mwjzGCLODgJMOhqHtbWAp4RdtGnaujHoEdsD-DmaKaSIC7097F2eXIRw4_BeT8HFCbCOdmnGlHfpbzN5D_sc4s9SYZj7wZlC3oZpix1AGVvSH-NSfImeeT2Ce3V6z9GPy0_fL76sr64_by4-Xq2NYGQ5SxAmPBeCS64dZ1J6YTrZeUN4r_u-tYb1tnbcG2lZa4iotRatFtbXngh-jt4dc_c5_ZodTGoXwLhx1NGlGVTbSNFJygv45h9wSHOOZTdFZSs5awUtUHeETE4A2XlVjt7pfFCUqMWZGtSiRi1q1OJM_XGm7sro61P-3O-cfRw8SSrA2xOgwejR52IpwAPXdbLhrFAfjtRtGN3hv79XX68330rFfwPffrY6</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>ZIZEK, B</creator><creator>POREDOS, P</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension</title><author>ZIZEK, B ; POREDOS, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4204-684024f344393ae3299f4c898fc03babb7dc2bd5e3fc9d27c045aa47a4df5f043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiovascular system</topic><topic>Cross-Sectional Studies</topic><topic>dilation of conduit arteries</topic><topic>endothelial dysfunction</topic><topic>essential hypertension</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>hyperinsulinaemia</topic><topic>Hyperinsulinism - physiopathology</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Insulin resistance</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric Oxide - physiology</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZIZEK, B</creatorcontrib><creatorcontrib>POREDOS, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZIZEK, B</au><au>POREDOS, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2001-02</date><risdate>2001</risdate><volume>249</volume><issue>2</issue><spage>189</spage><epage>197</epage><pages>189-197</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Žižek B, Poredoš P (University Medical Centre, Ljubljana, Slovenia). Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. J Intern Med 2001; 249: 189–197.
Objectives. To evaluate whether endothelium‐dependent (nitric oxide‐mediated) dilation of the brachial artery (BA) is impaired in patients being treated for essential hypertension (EH), and whether this abnormality can be detected in normotensive offspring of subjects with EH (familial trait, FT); and to investigate the interrelationship between flow‐mediated vasodilation (FMD) and hyperinsulinaemia/insulin resistance.
Design. Cross‐sectional study.
Setting. Angiology department at a teaching hospital.
Subjects. The study encompassed 172 subjects, of whom 46 were treated hypertonics aged 40–55 (49) years, and 44 age‐matched, normotensive volunteers as controls. We also investigated 41 normotonics with FT aged 20–30 (25) years and 41 age‐and sex‐matched controls without FT.
Main outcome measures. Using high‐resolution ultrasound, BA diameters at rest, during reactive hyperaemia (endothelium‐dependent dilation) and after sublingual glyceryl trinitrate (GTN) application (endothelium‐independent dilation) were measured.
Results. In hypertonics FMD was significantly lower than in controls [2.4 (2.9) vs. 7.4 (2.5)%; P < 0.00005], as was GTN‐induced dilation [12.1 (4.3) vs. 16.1 (4.6)%; P=0.0007]. In subjects with FT, FMD was also decreased compared with the control group [5.8 (4.1) vs. 10.0 (3.0)%; P < 0.00005]. The response to GTN was comparable in both groups of young subjects. FMD was negatively related to insulin concentration in all subjects studied (P < 0.00005).
Conclusions. In treated patients with EH, flow‐mediated dilation of the BA as well as endothelium‐independent dilation are decreased. In individuals with FT the endothelial function of the peripheral arteries is also altered in the absence of elevated blood pressure. Endothelial dysfunction is related to hyperinsulinaemia/insulin resistance, which could be one of the pathogenetic determinants of EH and its complications.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11240849</pmid><doi>10.1046/j.1365-2796.2001.00794.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Cardiovascular system Cross-Sectional Studies dilation of conduit arteries endothelial dysfunction essential hypertension Female Hemodynamics Humans hyperinsulinaemia Hyperinsulinism - physiopathology Hypertension - drug therapy Hypertension - genetics Hypertension - physiopathology Insulin resistance Investigative techniques, diagnostic techniques (general aspects) Linear Models Male Medical sciences Middle Aged Nitric Oxide - physiology Ultrasonic investigative techniques Ultrasonography Vasodilation |
| title | Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension |
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