Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat
The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/...
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| Veröffentlicht in: | European journal of pharmacology 1986-06, Vol.125 (3), p.429-435 |
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| container_title | European journal of pharmacology |
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| creator | DEUTZ, N. E. P CHAMULEAU, R. A. F. M BOVEE, W. M. M. J VAN DER WERF, A. J. M |
| description | The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/kg orally) 75 min before FVO. In the nimodipine-treated rats the post-ischemic overshoot of the EEG power density was significantly lower for the theta, alpha and beta band activity. 31P-NMR spectroscopy: the relative concentrations of phosphocreatine (PCr), ATP and Pi as well as intracellular pH were measured at different intervals after 10 min FVO (n = 10). All values normalised within 15-30 min after restoration of cerebral blood flow without significant differences between nimodipine-treated and control rats. It is concluded that pretreatment with nimodipine has a decreasing effect on the overshoot in EEG power density after transient incomplete forebrain ischemia. This effect was not correlated to significant changes in cerebral 'energy state', as measured by 31P-NMR spectroscopy. |
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E. P ; CHAMULEAU, R. A. F. M ; BOVEE, W. M. M. J ; VAN DER WERF, A. J. M</creator><creatorcontrib>DEUTZ, N. E. P ; CHAMULEAU, R. A. F. M ; BOVEE, W. M. M. J ; VAN DER WERF, A. J. M</creatorcontrib><description>The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/kg orally) 75 min before FVO. In the nimodipine-treated rats the post-ischemic overshoot of the EEG power density was significantly lower for the theta, alpha and beta band activity. 31P-NMR spectroscopy: the relative concentrations of phosphocreatine (PCr), ATP and Pi as well as intracellular pH were measured at different intervals after 10 min FVO (n = 10). All values normalised within 15-30 min after restoration of cerebral blood flow without significant differences between nimodipine-treated and control rats. It is concluded that pretreatment with nimodipine has a decreasing effect on the overshoot in EEG power density after transient incomplete forebrain ischemia. This effect was not correlated to significant changes in cerebral 'energy state', as measured by 31P-NMR spectroscopy.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>PMID: 3732400</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Brain Ischemia - physiopathology ; Cardiovascular system ; Electroencephalography ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Nicotinic Acids - pharmacology ; Nimodipine ; Pharmacology. 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J. M</creatorcontrib><title>Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/kg orally) 75 min before FVO. In the nimodipine-treated rats the post-ischemic overshoot of the EEG power density was significantly lower for the theta, alpha and beta band activity. 31P-NMR spectroscopy: the relative concentrations of phosphocreatine (PCr), ATP and Pi as well as intracellular pH were measured at different intervals after 10 min FVO (n = 10). All values normalised within 15-30 min after restoration of cerebral blood flow without significant differences between nimodipine-treated and control rats. It is concluded that pretreatment with nimodipine has a decreasing effect on the overshoot in EEG power density after transient incomplete forebrain ischemia. This effect was not correlated to significant changes in cerebral 'energy state', as measured by 31P-NMR spectroscopy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cardiovascular system</subject><subject>Electroencephalography</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nicotinic Acids - pharmacology</subject><subject>Nimodipine</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMo4zj6E4QsxF0hTdImWcpQHzA-kNmXNLlxMrRpTdqF_96qxdU98H0cDvcErXMpVEZETk_RmpCcZ1QpdY4uUjoSQgpFixVaMcEoJ2SNjpVzYMaEe4eD73rrBx8A9wFX1QPWwWKWv2Uvz-84DbMXNbZT9OHjF2k3QsQ-mL4bWhgBuz5CE7UP2CdzgM7rmeLxADjq8RKdOd0muFruBu3vq_32Mdu9Pjxt73bZICnJGFhFmHZOlpSaXGhJGlMUtDGEWlDS5MRK7hQ33EFRzplZa5RhRpRMOME26Pavdoj95wRprLt5DLStDtBPqRal4lJQNYvXizg1Hdh6iL7T8atefjPzm4XrZHTrog7Gp39Nkh-Js28wcG1D</recordid><startdate>19860624</startdate><enddate>19860624</enddate><creator>DEUTZ, N. E. P</creator><creator>CHAMULEAU, R. A. F. M</creator><creator>BOVEE, W. M. M. J</creator><creator>VAN DER WERF, A. J. M</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19860624</creationdate><title>Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat</title><author>DEUTZ, N. E. P ; CHAMULEAU, R. A. F. M ; BOVEE, W. M. M. J ; VAN DER WERF, A. J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p820-3ed903aff8622c17a80bc552bc02de98c10d84f94c4fe56d843ddc9c3c7637f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cardiovascular system</topic><topic>Electroencephalography</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nicotinic Acids - pharmacology</topic><topic>Nimodipine</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEUTZ, N. E. P</creatorcontrib><creatorcontrib>CHAMULEAU, R. A. F. M</creatorcontrib><creatorcontrib>BOVEE, W. M. M. J</creatorcontrib><creatorcontrib>VAN DER WERF, A. J. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEUTZ, N. E. P</au><au>CHAMULEAU, R. A. F. M</au><au>BOVEE, W. M. M. J</au><au>VAN DER WERF, A. J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1986-06-24</date><risdate>1986</risdate><volume>125</volume><issue>3</issue><spage>429</spage><epage>435</epage><pages>429-435</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/kg orally) 75 min before FVO. In the nimodipine-treated rats the post-ischemic overshoot of the EEG power density was significantly lower for the theta, alpha and beta band activity. 31P-NMR spectroscopy: the relative concentrations of phosphocreatine (PCr), ATP and Pi as well as intracellular pH were measured at different intervals after 10 min FVO (n = 10). All values normalised within 15-30 min after restoration of cerebral blood flow without significant differences between nimodipine-treated and control rats. It is concluded that pretreatment with nimodipine has a decreasing effect on the overshoot in EEG power density after transient incomplete forebrain ischemia. This effect was not correlated to significant changes in cerebral 'energy state', as measured by 31P-NMR spectroscopy.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>3732400</pmid><tpages>7</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1986-06, Vol.125 (3), p.429-435 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Brain Ischemia - physiopathology Cardiovascular system Electroencephalography Magnetic Resonance Spectroscopy Male Medical sciences Nicotinic Acids - pharmacology Nimodipine Pharmacology. Drug treatments Rats Rats, Inbred Strains Time Factors Vasodilator agents. Cerebral vasodilators |
| title | Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat |
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