Variability of gastric emptying measurements in man employing standardized radiolabeled meals
Extract: Radiolabeled liquid and solid portions of standardized 300-g meals were administered on four different study days to eight healthy subjects in an attempt to define the range of inter- and intrasubject variability in gastric emptying. Meal half emptying times, analysis of variance, and intra...
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| Veröffentlicht in: | Dig. Dis. Sci.; (United States) 1986-08, Vol.31 (8), p.799-806 |
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| creator | Brophy, C.M Moore, J.G Christian, P.E Egger, M.J Taylor, A.T |
| description | Extract: Radiolabeled liquid and solid portions of standardized 300-g meals were administered on four different study days to eight healthy subjects in an attempt to define the range of inter- and intrasubject variability in gastric emptying. Meal half emptying times, analysis of variance, and intraclass correlations were computed and compared within and between subjects. The mean solid half emptying time was 58 plus or minus 17 min (range 29-92), while the mean liquid half emptying time was 24 plus or minus 8 min (range 12-37). A nested random effects analysis of variance showed moderate intrasubject variability for solid emptying and high intrasubject variability for liquid emptying. The variability of solid and liquid emptying was comparable and relatively large when compared with other reports in the literature. The isotopic method for measuring gastric emptying is a valuable tool for investigating problems in gastric pathophysiology, particularly when differences between groups of subjects are sought. However, meal emptying time is a variable phenomenon in healthy subjects with significant inter- and intraindividual day-to-day differences. These day-to-day variations in gastric emptying must be considered in interpreting individual study results.(author) |
| doi_str_mv | 10.1007/BF01296046 |
| format | Article |
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Meal half emptying times, analysis of variance, and intraclass correlations were computed and compared within and between subjects. The mean solid half emptying time was 58 plus or minus 17 min (range 29-92), while the mean liquid half emptying time was 24 plus or minus 8 min (range 12-37). A nested random effects analysis of variance showed moderate intrasubject variability for solid emptying and high intrasubject variability for liquid emptying. The variability of solid and liquid emptying was comparable and relatively large when compared with other reports in the literature. The isotopic method for measuring gastric emptying is a valuable tool for investigating problems in gastric pathophysiology, particularly when differences between groups of subjects are sought. However, meal emptying time is a variable phenomenon in healthy subjects with significant inter- and intraindividual day-to-day differences. These day-to-day variations in gastric emptying must be considered in interpreting individual study results.(author)</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF01296046</identifier><identifier>PMID: 3731973</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>551001 - Physiological Systems- Tracer Techniques ; Adult ; AMINO ACIDS ; ANALISIS ESTADISTICO ; ANALYSE STATISTIQUE ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BEVERAGES ; Biological and medical sciences ; BODY ; CARBOXYLIC ACIDS ; CHELATING AGENTS ; Citrus ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; Dietary Proteins - metabolism ; Digestion. Liver. Biliary tract. Spleen. Pancreas ; DIGESTIVE SYSTEM ; DRUGS ; DTPA ; DYNAMIC FUNCTION STUDIES ; ELECTRON CAPTURE RADIOISOTOPES ; ESTOMAC ; ESTOMAGO ; FOOD ; Gastric Emptying ; GASTROINTESTINAL TRACT ; Humans ; Indium ; INDIUM 111 ; INDIUM ISOTOPES ; INTERMEDIATE MASS NUCLEI ; Investigative techniques, diagnostic techniques (general aspects) ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPE APPLICATIONS ; ISOTOPE RADIOACTIF ; ISOTOPES ; Male ; MAMMALS ; MAN ; Medical sciences ; MINUTES LIVING RADIOISOTOPES ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANS ; Pentetic Acid ; PHYSIOLOGY ; PRIMATES ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOISOTOPOS ; Radionuclide investigations ; RADIOPROTECTIVE SUBSTANCES ; SCINTILLATION COUNTING ; STOMACH ; Technetium Tc 99m Sulfur Colloid ; Time Factors ; TRACER TECHNIQUES ; VARIATIONS ; VERTEBRATES</subject><ispartof>Dig. Dis. 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Dis. Sci.; (United States)</title><addtitle>Dig Dis Sci</addtitle><description>Extract: Radiolabeled liquid and solid portions of standardized 300-g meals were administered on four different study days to eight healthy subjects in an attempt to define the range of inter- and intrasubject variability in gastric emptying. Meal half emptying times, analysis of variance, and intraclass correlations were computed and compared within and between subjects. The mean solid half emptying time was 58 plus or minus 17 min (range 29-92), while the mean liquid half emptying time was 24 plus or minus 8 min (range 12-37). A nested random effects analysis of variance showed moderate intrasubject variability for solid emptying and high intrasubject variability for liquid emptying. The variability of solid and liquid emptying was comparable and relatively large when compared with other reports in the literature. The isotopic method for measuring gastric emptying is a valuable tool for investigating problems in gastric pathophysiology, particularly when differences between groups of subjects are sought. However, meal emptying time is a variable phenomenon in healthy subjects with significant inter- and intraindividual day-to-day differences. These day-to-day variations in gastric emptying must be considered in interpreting individual study results.(author)</description><subject>551001 - Physiological Systems- Tracer Techniques</subject><subject>Adult</subject><subject>AMINO ACIDS</subject><subject>ANALISIS ESTADISTICO</subject><subject>ANALYSE STATISTIQUE</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BEVERAGES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>CARBOXYLIC ACIDS</subject><subject>CHELATING AGENTS</subject><subject>Citrus</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>Dietary Proteins - metabolism</subject><subject>Digestion. Liver. Biliary tract. Spleen. Pancreas</subject><subject>DIGESTIVE SYSTEM</subject><subject>DRUGS</subject><subject>DTPA</subject><subject>DYNAMIC FUNCTION STUDIES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ESTOMAC</subject><subject>ESTOMAGO</subject><subject>FOOD</subject><subject>Gastric Emptying</subject><subject>GASTROINTESTINAL TRACT</subject><subject>Humans</subject><subject>Indium</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPE RADIOACTIF</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>Pentetic Acid</subject><subject>PHYSIOLOGY</subject><subject>PRIMATES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOISOTOPOS</subject><subject>Radionuclide investigations</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>SCINTILLATION COUNTING</subject><subject>STOMACH</subject><subject>Technetium Tc 99m Sulfur Colloid</subject><subject>Time Factors</subject><subject>TRACER TECHNIQUES</subject><subject>VARIATIONS</subject><subject>VERTEBRATES</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFrFDEUh4NY6lp78SgIQxEPwmoymbxMjrbYWij0oPVWwptMsk2ZSdYke9j-9WbdpT29hO_L75EfIe8Z_coold_OLylrFdAOXpEFE5IvWwH9a7KgDOqZMXhD3ub8SClVksExOeaSMyX5gtz_weRx8JMv2ya6ZoW5JG8aO6_L1odVM1vMm2RnG0pufGhmDDs4xf80FwwjptE_2bFJOPo44WCneqnvpvyOHLk67OlhnpC7yx-_L34ub26vri--3ywNV31Ztj1I2ffgJGWCt1SC40KgG2BogUKv0EKnhKpfq5pgbWeAohOMGUor5SfkbJ8bc_E6G1-seTAxBGuKFpTJvuuq9HkvrVP8u7G56NlnY6cJg42brCWoTqoWqvhlL5oUc07W6XXyM6atZlTvCtcvhVf54yF1M8x2fFYPDVf-6cAxG5xcwmB8ftbqQgVsp33Yaw6jxlWqyt2vvmZ0suX_AP9cji4</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Brophy, C.M</creator><creator>Moore, J.G</creator><creator>Christian, P.E</creator><creator>Egger, M.J</creator><creator>Taylor, A.T</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19860801</creationdate><title>Variability of gastric emptying measurements in man employing standardized radiolabeled meals</title><author>Brophy, C.M ; Moore, J.G ; Christian, P.E ; Egger, M.J ; Taylor, A.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-28677886f701532076f355afb6b260689ae649591577885124c60af511c0089a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>551001 - Physiological Systems- Tracer Techniques</topic><topic>Adult</topic><topic>AMINO ACIDS</topic><topic>ANALISIS ESTADISTICO</topic><topic>ANALYSE STATISTIQUE</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BEVERAGES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>CARBOXYLIC ACIDS</topic><topic>CHELATING AGENTS</topic><topic>Citrus</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>Dietary Proteins - metabolism</topic><topic>Digestion. Liver. Biliary tract. Spleen. Pancreas</topic><topic>DIGESTIVE SYSTEM</topic><topic>DRUGS</topic><topic>DTPA</topic><topic>DYNAMIC FUNCTION STUDIES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ESTOMAC</topic><topic>ESTOMAGO</topic><topic>FOOD</topic><topic>Gastric Emptying</topic><topic>GASTROINTESTINAL TRACT</topic><topic>Humans</topic><topic>Indium</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPE RADIOACTIF</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>Pentetic Acid</topic><topic>PHYSIOLOGY</topic><topic>PRIMATES</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOISOTOPOS</topic><topic>Radionuclide investigations</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>SCINTILLATION COUNTING</topic><topic>STOMACH</topic><topic>Technetium Tc 99m Sulfur Colloid</topic><topic>Time Factors</topic><topic>TRACER TECHNIQUES</topic><topic>VARIATIONS</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brophy, C.M</creatorcontrib><creatorcontrib>Moore, J.G</creatorcontrib><creatorcontrib>Christian, P.E</creatorcontrib><creatorcontrib>Egger, M.J</creatorcontrib><creatorcontrib>Taylor, A.T</creatorcontrib><creatorcontrib>Univ. of Utah School of Medicine, Salt Lake City</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Dig. Dis. Sci.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brophy, C.M</au><au>Moore, J.G</au><au>Christian, P.E</au><au>Egger, M.J</au><au>Taylor, A.T</au><aucorp>Univ. of Utah School of Medicine, Salt Lake City</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variability of gastric emptying measurements in man employing standardized radiolabeled meals</atitle><jtitle>Dig. Dis. Sci.; (United States)</jtitle><addtitle>Dig Dis Sci</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>31</volume><issue>8</issue><spage>799</spage><epage>806</epage><pages>799-806</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Extract: Radiolabeled liquid and solid portions of standardized 300-g meals were administered on four different study days to eight healthy subjects in an attempt to define the range of inter- and intrasubject variability in gastric emptying. Meal half emptying times, analysis of variance, and intraclass correlations were computed and compared within and between subjects. The mean solid half emptying time was 58 plus or minus 17 min (range 29-92), while the mean liquid half emptying time was 24 plus or minus 8 min (range 12-37). A nested random effects analysis of variance showed moderate intrasubject variability for solid emptying and high intrasubject variability for liquid emptying. The variability of solid and liquid emptying was comparable and relatively large when compared with other reports in the literature. The isotopic method for measuring gastric emptying is a valuable tool for investigating problems in gastric pathophysiology, particularly when differences between groups of subjects are sought. However, meal emptying time is a variable phenomenon in healthy subjects with significant inter- and intraindividual day-to-day differences. These day-to-day variations in gastric emptying must be considered in interpreting individual study results.(author)</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3731973</pmid><doi>10.1007/BF01296046</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Dig. Dis. Sci.; (United States), 1986-08, Vol.31 (8), p.799-806 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 551001 - Physiological Systems- Tracer Techniques Adult AMINO ACIDS ANALISIS ESTADISTICO ANALYSE STATISTIQUE ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BEVERAGES Biological and medical sciences BODY CARBOXYLIC ACIDS CHELATING AGENTS Citrus COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES Dietary Proteins - metabolism Digestion. Liver. Biliary tract. Spleen. Pancreas DIGESTIVE SYSTEM DRUGS DTPA DYNAMIC FUNCTION STUDIES ELECTRON CAPTURE RADIOISOTOPES ESTOMAC ESTOMAGO FOOD Gastric Emptying GASTROINTESTINAL TRACT Humans Indium INDIUM 111 INDIUM ISOTOPES INTERMEDIATE MASS NUCLEI Investigative techniques, diagnostic techniques (general aspects) ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPE RADIOACTIF ISOTOPES Male MAMMALS MAN Medical sciences MINUTES LIVING RADIOISOTOPES NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS Pentetic Acid PHYSIOLOGY PRIMATES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOISOTOPOS Radionuclide investigations RADIOPROTECTIVE SUBSTANCES SCINTILLATION COUNTING STOMACH Technetium Tc 99m Sulfur Colloid Time Factors TRACER TECHNIQUES VARIATIONS VERTEBRATES |
| title | Variability of gastric emptying measurements in man employing standardized radiolabeled meals |
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