Immunosuppressive factors from adult T-cell leukemia cells
The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied in vitro. Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1986-09, Vol.46 (9), p.4458-4462 |
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| container_issue | 9 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | SHIRAKAWA, F TANAKA, Y ODA, S CHIBA, S SUZUKI, H ETO, S YAMASHITA, U |
| description | The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied in vitro. Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte proliferative responses induced with concanavalin A when cultured together. The sera from ATL patients and the culture supernatants from ATL cells and ATL cell lines also suppressed normal lymphocyte proliferative responses induced with concanavalin A. By Sephacryl S-200 column chromatography, the suppressive factors were fractionated as a single peak with the molecular weights of 50,000 to 70,000. The suppressive factors were unstable to acid treatment but stable to the treatment with base, heat, freezing-thawing, and trypsin. The factors suppressed the production of interleukin 2 by T-cells and the responsiveness of T-cells to interleukin 2, but not the expression of interleukin 2 receptors on T-cells and the production of interleukin 1 by monocytes. These results suggest that the immunosuppressive factors produced by ATL cells have some roles in the induction of immunodeficient states in ATL patients. |
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Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte proliferative responses induced with concanavalin A when cultured together. The sera from ATL patients and the culture supernatants from ATL cells and ATL cell lines also suppressed normal lymphocyte proliferative responses induced with concanavalin A. By Sephacryl S-200 column chromatography, the suppressive factors were fractionated as a single peak with the molecular weights of 50,000 to 70,000. The suppressive factors were unstable to acid treatment but stable to the treatment with base, heat, freezing-thawing, and trypsin. The factors suppressed the production of interleukin 2 by T-cells and the responsiveness of T-cells to interleukin 2, but not the expression of interleukin 2 receptors on T-cells and the production of interleukin 1 by monocytes. These results suggest that the immunosuppressive factors produced by ATL cells have some roles in the induction of immunodeficient states in ATL patients.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 2873886</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Cell Line ; Concanavalin A - pharmacology ; Deltaretrovirus Infections - immunology ; Hematologic and hematopoietic diseases ; Histocompatibility Antigens Class II - immunology ; HLA-DR Antigens ; Humans ; Immune Tolerance ; Immunosuppressive Agents - analysis ; Immunosuppressive Agents - immunology ; Interleukin-1 - biosynthesis ; Interleukin-2 - biosynthesis ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocyte Activation ; Medical sciences ; Monocytes - immunology ; Receptors, Immunologic - metabolism ; Receptors, Interleukin-2 ; T-Lymphocytes - immunology</subject><ispartof>Cancer research (Chicago, Ill.), 1986-09, Vol.46 (9), p.4458-4462</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8814605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2873886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIRAKAWA, F</creatorcontrib><creatorcontrib>TANAKA, Y</creatorcontrib><creatorcontrib>ODA, S</creatorcontrib><creatorcontrib>CHIBA, S</creatorcontrib><creatorcontrib>SUZUKI, H</creatorcontrib><creatorcontrib>ETO, S</creatorcontrib><creatorcontrib>YAMASHITA, U</creatorcontrib><title>Immunosuppressive factors from adult T-cell leukemia cells</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied in vitro. Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte proliferative responses induced with concanavalin A when cultured together. The sera from ATL patients and the culture supernatants from ATL cells and ATL cell lines also suppressed normal lymphocyte proliferative responses induced with concanavalin A. By Sephacryl S-200 column chromatography, the suppressive factors were fractionated as a single peak with the molecular weights of 50,000 to 70,000. The suppressive factors were unstable to acid treatment but stable to the treatment with base, heat, freezing-thawing, and trypsin. The factors suppressed the production of interleukin 2 by T-cells and the responsiveness of T-cells to interleukin 2, but not the expression of interleukin 2 receptors on T-cells and the production of interleukin 1 by monocytes. These results suggest that the immunosuppressive factors produced by ATL cells have some roles in the induction of immunodeficient states in ATL patients.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Concanavalin A - pharmacology</subject><subject>Deltaretrovirus Infections - immunology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunosuppressive Agents - analysis</subject><subject>Immunosuppressive Agents - immunology</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocyte Activation</subject><subject>Medical sciences</subject><subject>Monocytes - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Interleukin-2</subject><subject>T-Lymphocytes - immunology</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09LxDAUxIMo67r6EYQexFuhaf7Wmyy6Lix4Wc8lTV6w2rQ1rxH89naxeBqG-fHezBlZU8F0rjgX52RdFIXOBVflJblC_JitoIVYkVWpFdNarsnDPoTUD5jGMQJi-w2ZN3YaImY-DiEzLnVTdswtdF3WQfqE0Jrs5PCaXHjTIdwsuiFvz0_H7Ut-eN3tt4-H_L2UesqlYLKkjVfeK-qAVc5WJYAFYEI1puCelZRp7njDqHZVUwhWAQfNG7DUO7Yh9393xzh8JcCpDi2eGpgehoS1khWXXPMZvF3A1ARw9RjbYOJPvYyd87slN2hN56PpbYv_mNaUy_n5L90UXls</recordid><startdate>19860901</startdate><enddate>19860901</enddate><creator>SHIRAKAWA, F</creator><creator>TANAKA, Y</creator><creator>ODA, S</creator><creator>CHIBA, S</creator><creator>SUZUKI, H</creator><creator>ETO, S</creator><creator>YAMASHITA, U</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19860901</creationdate><title>Immunosuppressive factors from adult T-cell leukemia cells</title><author>SHIRAKAWA, F ; TANAKA, Y ; ODA, S ; CHIBA, S ; SUZUKI, H ; ETO, S ; YAMASHITA, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-653621bf7ff71de39dc92eecee357ba04f321384d4b318d9b0539e4e84bec1fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Concanavalin A - pharmacology</topic><topic>Deltaretrovirus Infections - immunology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>HLA-DR Antigens</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunosuppressive Agents - analysis</topic><topic>Immunosuppressive Agents - immunology</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocyte Activation</topic><topic>Medical sciences</topic><topic>Monocytes - immunology</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Interleukin-2</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIRAKAWA, F</creatorcontrib><creatorcontrib>TANAKA, Y</creatorcontrib><creatorcontrib>ODA, S</creatorcontrib><creatorcontrib>CHIBA, S</creatorcontrib><creatorcontrib>SUZUKI, H</creatorcontrib><creatorcontrib>ETO, S</creatorcontrib><creatorcontrib>YAMASHITA, U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIRAKAWA, F</au><au>TANAKA, Y</au><au>ODA, S</au><au>CHIBA, S</au><au>SUZUKI, H</au><au>ETO, S</au><au>YAMASHITA, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive factors from adult T-cell leukemia cells</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1986-09-01</date><risdate>1986</risdate><volume>46</volume><issue>9</issue><spage>4458</spage><epage>4462</epage><pages>4458-4462</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied in vitro. Peripheral blood lymphocytes from ATL patients and ATL cell lines such as Hut 102, MT 1, and MT 2 were not activated to proliferate by the stimulation with concanavalin A and suppressed normal lymphocyte proliferative responses induced with concanavalin A when cultured together. The sera from ATL patients and the culture supernatants from ATL cells and ATL cell lines also suppressed normal lymphocyte proliferative responses induced with concanavalin A. By Sephacryl S-200 column chromatography, the suppressive factors were fractionated as a single peak with the molecular weights of 50,000 to 70,000. The suppressive factors were unstable to acid treatment but stable to the treatment with base, heat, freezing-thawing, and trypsin. The factors suppressed the production of interleukin 2 by T-cells and the responsiveness of T-cells to interleukin 2, but not the expression of interleukin 2 receptors on T-cells and the production of interleukin 1 by monocytes. These results suggest that the immunosuppressive factors produced by ATL cells have some roles in the induction of immunodeficient states in ATL patients.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>2873886</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1986-09, Vol.46 (9), p.4458-4462 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | AIDS/HIV Biological and medical sciences Cell Line Concanavalin A - pharmacology Deltaretrovirus Infections - immunology Hematologic and hematopoietic diseases Histocompatibility Antigens Class II - immunology HLA-DR Antigens Humans Immune Tolerance Immunosuppressive Agents - analysis Immunosuppressive Agents - immunology Interleukin-1 - biosynthesis Interleukin-2 - biosynthesis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation Medical sciences Monocytes - immunology Receptors, Immunologic - metabolism Receptors, Interleukin-2 T-Lymphocytes - immunology |
| title | Immunosuppressive factors from adult T-cell leukemia cells |
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