Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy
Basic Helix-Loop-Helix (bHLH) transcription factors play essential role in differentiation of several cell types including neurons. We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons. To examine the function of class A bHLH tra...
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| Veröffentlicht in: | Neuroscience letters 1994-08, Vol.177 (1), p.87-90 |
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| creator | Suda, Kikuo Nornes, Howard O. Neuman, Toomas |
| description | Basic Helix-Loop-Helix (bHLH) transcription factors play essential role in differentiation of several cell types including neurons. We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons. To examine the function of class A bHLH transcription factors we blocked their expression using antisense oligonucleotides. Simultaneous blocking of class A bHLH transcription factors in cultured neural tube cells results in the reduction of differentiating neurons. Blocking the expression of individual class A bHLH transcription factors has no detectable effect. These results demonstrate that class A bHLH transcription factors have a functional redundancy during neuronal development. |
| doi_str_mv | 10.1016/0304-3940(94)90051-5 |
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We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons. To examine the function of class A bHLH transcription factors we blocked their expression using antisense oligonucleotides. Simultaneous blocking of class A bHLH transcription factors in cultured neural tube cells results in the reduction of differentiating neurons. Blocking the expression of individual class A bHLH transcription factors has no detectable effect. These results demonstrate that class A bHLH transcription factors have a functional redundancy during neuronal development.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(94)90051-5</identifier><identifier>PMID: 7824188</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Base Sequence ; bHLH ; Biological and medical sciences ; Cell Differentiation ; Central Nervous System - embryology ; Chick Embryo ; Development. Senescence. Regeneration. Transplantation ; DNA, Complementary - genetics ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - classification ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Early neurogenesis ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental - drug effects ; Helix-Loop-Helix Motifs ; Interneurons - enzymology ; Molecular Sequence Data ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Neural tube ; Neuronal differentiation ; Oligonucleotides, Antisense - pharmacology ; TCF Transcription Factors ; Transcription Factor 7-Like 1 Protein ; Transcription Factors - biosynthesis ; Transcription Factors - classification ; Transcription Factors - genetics ; Transcription Factors - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1994-08, Vol.177 (1), p.87-90</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-590591ba01d93abf3f62e4e9442da2ce5f7598150248de1d27dd8249db779b203</citedby><cites>FETCH-LOGICAL-c417t-590591ba01d93abf3f62e4e9442da2ce5f7598150248de1d27dd8249db779b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(94)90051-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4192478$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7824188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suda, Kikuo</creatorcontrib><creatorcontrib>Nornes, Howard O.</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><title>Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Basic Helix-Loop-Helix (bHLH) transcription factors play essential role in differentiation of several cell types including neurons. We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons. To examine the function of class A bHLH transcription factors we blocked their expression using antisense oligonucleotides. Simultaneous blocking of class A bHLH transcription factors in cultured neural tube cells results in the reduction of differentiating neurons. Blocking the expression of individual class A bHLH transcription factors has no detectable effect. These results demonstrate that class A bHLH transcription factors have a functional redundancy during neuronal development.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>bHLH</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Central Nervous System - embryology</subject><subject>Chick Embryo</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>DNA, Complementary - genetics</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - classification</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Early neurogenesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Helix-Loop-Helix Motifs</subject><subject>Interneurons - enzymology</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neural tube</subject><subject>Neuronal differentiation</subject><subject>Oligonucleotides, Antisense - pharmacology</subject><subject>TCF Transcription Factors</subject><subject>Transcription Factor 7-Like 1 Protein</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - classification</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGOFCEQhonRrOPqG2jCwRg9tAINTePBZDNR12QSL3omNBSK9kAL9MR5BN_a7p3JHPVUJPXVn6I-hJ5S8poS2r0hLeFNqzh5qfgrRYigjbiHNrSXrJFKsvtoc0Eeokel_CArJPgVupI947TvN-jPdjSl4Bs8mBIsvoUx_G52KU3N3RPXbGKxOUw1pIi9sTXlgkPEYPJ4xKWab1Bw8th-D_YnjjBnM-I6D4AdHGBM0x5ifYvhEBxEC9injP0c7Zq3kBncHJ2J9vgYPfBmLPDkXK_R1w_vv2xvm93nj5-2N7vGciprIxQRig6GUKdaM_jWdww4KM6ZM8yC8FKongrCeO-AOiadWz6r3CClGhhpr9GLU-6U068ZStX7UCyMo4mQ5qJlp7ggnP8XpF3XdqxdE_kJtDmVksHrKYe9yUdNiV5V6dWDXj1oxfWdKi2WsWfn_HnYg7sMnd0s_efnvinWjH4xYUO5YJwqxuWKvTthsBztECDrYsN6ahcy2KpdCv_e4y-qerDW</recordid><startdate>19940815</startdate><enddate>19940815</enddate><creator>Suda, Kikuo</creator><creator>Nornes, Howard O.</creator><creator>Neuman, Toomas</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940815</creationdate><title>Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy</title><author>Suda, Kikuo ; Nornes, Howard O. ; Neuman, Toomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-590591ba01d93abf3f62e4e9442da2ce5f7598150248de1d27dd8249db779b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>bHLH</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Central Nervous System - embryology</topic><topic>Chick Embryo</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>DNA, Complementary - genetics</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - classification</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Early neurogenesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Helix-Loop-Helix Motifs</topic><topic>Interneurons - enzymology</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neural tube</topic><topic>Neuronal differentiation</topic><topic>Oligonucleotides, Antisense - pharmacology</topic><topic>TCF Transcription Factors</topic><topic>Transcription Factor 7-Like 1 Protein</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - classification</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suda, Kikuo</creatorcontrib><creatorcontrib>Nornes, Howard O.</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suda, Kikuo</au><au>Nornes, Howard O.</au><au>Neuman, Toomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1994-08-15</date><risdate>1994</risdate><volume>177</volume><issue>1</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Basic Helix-Loop-Helix (bHLH) transcription factors play essential role in differentiation of several cell types including neurons. We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons. To examine the function of class A bHLH transcription factors we blocked their expression using antisense oligonucleotides. Simultaneous blocking of class A bHLH transcription factors in cultured neural tube cells results in the reduction of differentiating neurons. Blocking the expression of individual class A bHLH transcription factors has no detectable effect. These results demonstrate that class A bHLH transcription factors have a functional redundancy during neuronal development.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7824188</pmid><doi>10.1016/0304-3940(94)90051-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1994-08, Vol.177 (1), p.87-90 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Base Sequence bHLH Biological and medical sciences Cell Differentiation Central Nervous System - embryology Chick Embryo Development. Senescence. Regeneration. Transplantation DNA, Complementary - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - classification DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Early neurogenesis Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Helix-Loop-Helix Motifs Interneurons - enzymology Molecular Sequence Data Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural tube Neuronal differentiation Oligonucleotides, Antisense - pharmacology TCF Transcription Factors Transcription Factor 7-Like 1 Protein Transcription Factors - biosynthesis Transcription Factors - classification Transcription Factors - genetics Transcription Factors - physiology Vertebrates: nervous system and sense organs |
| title | Class A basic Helix-Loop-Helix transcription factors in early stages of chick neural tube development: evidence for functional redundancy |
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