EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE
SUMMARY 1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s). 2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1986-04, Vol.13 (4), p.271-276 |
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| container_title | Clinical and experimental pharmacology & physiology |
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| creator | Ziogas, J. Story, D. F. Rand, M. J. |
| description | SUMMARY
1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s).
2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced efflux of radioactivity.
3. The facilitation of noradrenergic transmission in rat caudal arteries and guinea‐pig atria was blocked by the angiotensin II receptor antagonist saralasin, but was not altered by converting enzyme inhibitors.
4. In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril. |
| doi_str_mv | 10.1111/j.1440-1681.1986.tb00347.x |
| format | Article |
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1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s).
2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced efflux of radioactivity.
3. The facilitation of noradrenergic transmission in rat caudal arteries and guinea‐pig atria was blocked by the angiotensin II receptor antagonist saralasin, but was not altered by converting enzyme inhibitors.
4. In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1986.tb00347.x</identifier><identifier>PMID: 3015458</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Angiotensin II - metabolism ; Animals ; Blood Pressure - drug effects ; Captopril - pharmacology ; converting enzyme inhibitors ; Decerebrate State ; Enalapril - pharmacology ; Female ; Guinea Pigs ; In Vitro Techniques ; Male ; noradrenergic transmission ; Norepinephrine - pharmacology ; Oligopeptides - pharmacology ; prejunctional receptors ; Rats ; Rats, Inbred Strains ; Receptors, Angiotensin - drug effects ; Renin - metabolism ; renin substrate ; Saralasin - pharmacology ; Synaptic Transmission - drug effects ; tetradecapeptide ; Vasoconstriction - drug effects</subject><ispartof>Clinical and experimental pharmacology & physiology, 1986-04, Vol.13 (4), p.271-276</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4071-e7a48e5cc9fd6d1ac62c088425a5e4cb3988b250daff66109fa3ddad80a3b6203</citedby><cites>FETCH-LOGICAL-c4071-e7a48e5cc9fd6d1ac62c088425a5e4cb3988b250daff66109fa3ddad80a3b6203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1986.tb00347.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1986.tb00347.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3015458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ziogas, J.</creatorcontrib><creatorcontrib>Story, D. F.</creatorcontrib><creatorcontrib>Rand, M. J.</creatorcontrib><title>EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s).
2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced efflux of radioactivity.
3. The facilitation of noradrenergic transmission in rat caudal arteries and guinea‐pig atria was blocked by the angiotensin II receptor antagonist saralasin, but was not altered by converting enzyme inhibitors.
4. In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril.</description><subject>Angiotensin II - metabolism</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Captopril - pharmacology</subject><subject>converting enzyme inhibitors</subject><subject>Decerebrate State</subject><subject>Enalapril - pharmacology</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>noradrenergic transmission</subject><subject>Norepinephrine - pharmacology</subject><subject>Oligopeptides - pharmacology</subject><subject>prejunctional receptors</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Angiotensin - drug effects</subject><subject>Renin - metabolism</subject><subject>renin substrate</subject><subject>Saralasin - pharmacology</subject><subject>Synaptic Transmission - drug effects</subject><subject>tetradecapeptide</subject><subject>Vasoconstriction - drug effects</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc2O0zAUhS0EGsrAIyBZLFiRYMeO47BA8iRuJyhKQn5UsbLcxJFaWjokrabzDvPQONOqe7zxlc89n6VzAPiEkYvt-bpxMaXIwYxjF4ecuYcVQoQG7ukVmF2l12CGCPIdzAP0Frwbxw1CyEeM3IAbgrBPfT4Dz3I-l1FdwXwOa1mXIpaRKGRRJ7GEpcySDFbNXWWFWsI8g0mVp3aMYVHKQtjXJM9ezHaEkWhikUJR1rL89QUumiSTwimSBRR1mQgosnhiFEl9bwmT4y7N8xdWVTWlfA_e9Ho7mg-X-xY0c1lH906aL5JIpE5LUYAdE2jKjd-2Yd-xDuuWeS3inHq-9g1tVyTkfOX5qNN9zxhGYa9J1-mOI01WzEPkFnw-cx-G_d-jGQ9qtx5bs93qP2Z_HFXAQkpDHNrFb-fFdtiP42B69TCsd3p4UhipqQq1UVPeaspbTVWoSxXqZM0fL78cVzvTXa2X7K3-_aw_rrfm6T_IKpKFF2ALcM6A9XgwpytAD78VC0jgq2W2UD-X7McySJlakn9NMpz0</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>Ziogas, J.</creator><creator>Story, D. F.</creator><creator>Rand, M. J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE</title><author>Ziogas, J. ; Story, D. F. ; Rand, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4071-e7a48e5cc9fd6d1ac62c088425a5e4cb3988b250daff66109fa3ddad80a3b6203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Angiotensin II - metabolism</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Captopril - pharmacology</topic><topic>converting enzyme inhibitors</topic><topic>Decerebrate State</topic><topic>Enalapril - pharmacology</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>noradrenergic transmission</topic><topic>Norepinephrine - pharmacology</topic><topic>Oligopeptides - pharmacology</topic><topic>prejunctional receptors</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Angiotensin - drug effects</topic><topic>Renin - metabolism</topic><topic>renin substrate</topic><topic>Saralasin - pharmacology</topic><topic>Synaptic Transmission - drug effects</topic><topic>tetradecapeptide</topic><topic>Vasoconstriction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ziogas, J.</creatorcontrib><creatorcontrib>Story, D. F.</creatorcontrib><creatorcontrib>Rand, M. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ziogas, J.</au><au>Story, D. F.</au><au>Rand, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1986-04</date><risdate>1986</risdate><volume>13</volume><issue>4</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s).
2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced efflux of radioactivity.
3. The facilitation of noradrenergic transmission in rat caudal arteries and guinea‐pig atria was blocked by the angiotensin II receptor antagonist saralasin, but was not altered by converting enzyme inhibitors.
4. In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3015458</pmid><doi>10.1111/j.1440-1681.1986.tb00347.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and experimental pharmacology & physiology, 1986-04, Vol.13 (4), p.271-276 |
| issn | 0305-1870 1440-1681 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Angiotensin II - metabolism Animals Blood Pressure - drug effects Captopril - pharmacology converting enzyme inhibitors Decerebrate State Enalapril - pharmacology Female Guinea Pigs In Vitro Techniques Male noradrenergic transmission Norepinephrine - pharmacology Oligopeptides - pharmacology prejunctional receptors Rats Rats, Inbred Strains Receptors, Angiotensin - drug effects Renin - metabolism renin substrate Saralasin - pharmacology Synaptic Transmission - drug effects tetradecapeptide Vasoconstriction - drug effects |
| title | EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE |
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