EFFECTS OF TETRADECAPEPTIDE RENIN SUBSTRATE ON ISOLATED PREPARATIONS OF RAT CAUDAL ARTERY, GUINEA-PIG ATRIA AND ON PITHED RAT BLOOD PRESSURE

SUMMARY 1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s). 2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1986-04, Vol.13 (4), p.271-276
Hauptverfasser:	Ziogas, J., Story, D. F., Rand, M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Blood Pressure - drug effects Captopril - pharmacology converting enzyme inhibitors Decerebrate State Enalapril - pharmacology Female Guinea Pigs In Vitro Techniques Male noradrenergic transmission Norepinephrine - pharmacology Oligopeptides - pharmacology prejunctional receptors Rats Rats, Inbred Strains Receptors, Angiotensin - drug effects Renin - metabolism renin substrate Saralasin - pharmacology Synaptic Transmission - drug effects tetradecapeptide Vasoconstriction - drug effects
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Zusammenfassung:	SUMMARY 1. In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s). 2. In guinea‐pig isolated atria, previously incubated in 3H‐noradrenaline, tetradecapeptide renin substrate enhanced the stimulation‐induced efflux of radioactivity. 3. The facilitation of noradrenergic transmission in rat caudal arteries and guinea‐pig atria was blocked by the angiotensin II receptor antagonist saralasin, but was not altered by converting enzyme inhibitors. 4. In the pithed rat tetradecapeptide renin substrate increased blood pressure and this effect was reduced by the converting enzyme inhibitor, captopril.
ISSN:	0305-1870 1440-1681
DOI:	10.1111/j.1440-1681.1986.tb00347.x