Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer

The p66/p51 human immunodeficiency virus type 1 reverse transcriptase is a heterodimer with identical N‐terminal amino acid sequences. The enzyme contains two polymerization domains and one RNase H domain, which is located at the C‐terminus of the p66 subunit. Both polymerization domains fold into f...

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Veröffentlicht in:	Journal of molecular recognition 1994-06, Vol.7 (2), p.157-161
Hauptverfasser:	Ding, Jianping, Jacobo-Molina, Alfredo, Tantillo, Chris, Lu, Xiaode, Nanni, Raymond G., Arnold, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS/HIV Binding Sites Crystallography DNA - metabolism DNA Primers DNA-protein interactions HIV Reverse Transcriptase HIV-1 - enzymology Humans In Vitro Techniques Macromolecular Substances Models, Molecular Molecular Structure Molecular Weight Polymerase Protein Conformation RNA-Directed DNA Polymerase - chemistry RNA-Directed DNA Polymerase - metabolism Substrate Specificity
Online-Zugang:	Volltext
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