Insulin increases the daily food intake of diabetic rats on high and low fat diets
The effects of insulin dose and diet composition on daily food intake were investigated by IV infusion of insulin in doses of 2 to 5 U/day into diabetic rats consuming either a high CHO or high fat diet. The daily food intake of the diabetic rats on both diets increased significantly over baseline l...
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| Veröffentlicht in: | Physiology & behavior 1994-11, Vol.56 (5), p.983-991 |
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| creator | Willing, A.E. Walls, E.K. Koopmans, H.S. |
| description | The effects of insulin dose and diet composition on daily food intake were investigated by IV infusion of insulin in doses of 2 to 5 U/day into diabetic rats consuming either a high CHO or high fat diet. The daily food intake of the diabetic rats on both diets increased significantly over baseline levels (
p < .01) at the low insulin doses and was maintained at these elevated levels through the 5 U/day dose. Insulin increased the rate of weight gain from 1g/day during baseline to 2 and 2.5 g/day in high CHO and high fat fed diabetics (
p < .01). These results show that treatment of diabetic rats with continuous low doses of IV insulin results in a 40% increase in daily food intake regardless of the diet consumed and this increase is accompanied by an increase in rate of body weight gain. While the high fat fed diabetics were relatively hypoglycemic, these increases in intake are not the result of insulin-induced hypoglycemia, since blood glucose concentrations are significantly elevated when the increases occur at the lower insulin doses (
p < .01). Thus, peripheralinsulin infused at physiological levels stimulates rather than inhibits daily food intake. |
| doi_str_mv | 10.1016/0031-9384(94)90333-6 |
| format | Article |
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p < .01) at the low insulin doses and was maintained at these elevated levels through the 5 U/day dose. Insulin increased the rate of weight gain from 1g/day during baseline to 2 and 2.5 g/day in high CHO and high fat fed diabetics (
p < .01). These results show that treatment of diabetic rats with continuous low doses of IV insulin results in a 40% increase in daily food intake regardless of the diet consumed and this increase is accompanied by an increase in rate of body weight gain. While the high fat fed diabetics were relatively hypoglycemic, these increases in intake are not the result of insulin-induced hypoglycemia, since blood glucose concentrations are significantly elevated when the increases occur at the lower insulin doses (
p < .01). Thus, peripheralinsulin infused at physiological levels stimulates rather than inhibits daily food intake.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(94)90333-6</identifier><identifier>PMID: 7824601</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Body weight ; Body Weight - drug effects ; Diabetes ; Diabetes Mellitus, Experimental - physiopathology ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dose-Response Relationship, Drug ; Eating - drug effects ; Energy Intake - drug effects ; Feeding. Feeding behavior ; Food intake ; Fundamental and applied biological sciences. Psychology ; High CHO diet ; High fat diet ; Hypoglycemia ; Infusions, Intravenous ; Insulin ; Insulin - pharmacology ; Male ; Rats ; Rats, Inbred Lew ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Physiology & behavior, 1994-11, Vol.56 (5), p.983-991</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-349ab322622fcf5352ed177f1712ea895705bf6a667d82920e2e8ba6a467cfb23</citedby><cites>FETCH-LOGICAL-c417t-349ab322622fcf5352ed177f1712ea895705bf6a667d82920e2e8ba6a467cfb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938494903336$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3398861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7824601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Willing, A.E.</creatorcontrib><creatorcontrib>Walls, E.K.</creatorcontrib><creatorcontrib>Koopmans, H.S.</creatorcontrib><title>Insulin increases the daily food intake of diabetic rats on high and low fat diets</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>The effects of insulin dose and diet composition on daily food intake were investigated by IV infusion of insulin in doses of 2 to 5 U/day into diabetic rats consuming either a high CHO or high fat diet. The daily food intake of the diabetic rats on both diets increased significantly over baseline levels (
p < .01) at the low insulin doses and was maintained at these elevated levels through the 5 U/day dose. Insulin increased the rate of weight gain from 1g/day during baseline to 2 and 2.5 g/day in high CHO and high fat fed diabetics (
p < .01). These results show that treatment of diabetic rats with continuous low doses of IV insulin results in a 40% increase in daily food intake regardless of the diet consumed and this increase is accompanied by an increase in rate of body weight gain. While the high fat fed diabetics were relatively hypoglycemic, these increases in intake are not the result of insulin-induced hypoglycemia, since blood glucose concentrations are significantly elevated when the increases occur at the lower insulin doses (
p < .01). Thus, peripheralinsulin infused at physiological levels stimulates rather than inhibits daily food intake.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body weight</subject><subject>Body Weight - drug effects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - drug effects</subject><subject>Energy Intake - drug effects</subject><subject>Feeding. Feeding behavior</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High CHO diet</subject><subject>High fat diet</subject><subject>Hypoglycemia</subject><subject>Infusions, Intravenous</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo6-zqP1DIQWQ9tOark85lQRY_FhYEUfAWqpOKE-3prElG2X9vNzPMUYuCOrxPFcVDyDPOXnPG9RvGJO-sHNSlVa8sk1J2-gHZ8MHIrmfm20OyOSGPyXmtP9hSUskzcmYGoTTjG_L5Zq77Kc00zb4gVKy0bZEGSNM9jTmHJWjwE2mONCQYsSVPC7RK80y36fuWwhzolP_QCG0hsNUn5FGEqeLT47wgX9-_-3L9sbv99OHm-u1t5xU3rZPKwiiF0EJEH3vZCwzcmMgNFwiD7Q3rx6hBaxMGYQVDgcMIGpQ2Po5CXpCXh7t3Jf_aY21ul6rHaYIZ8746o61SkvP_glxrphRTC6gOoC-51oLR3ZW0g3LvOHOrc7cKdatQZ5denTu9rD0_3t-POwynpaPkJX9xzKF6mGKB2ad6wqS0w6BX7OqA4SLtd8Liqk84ewypoG8u5PTvP_4CpvKbmQ</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Willing, A.E.</creator><creator>Walls, E.K.</creator><creator>Koopmans, H.S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>Insulin increases the daily food intake of diabetic rats on high and low fat diets</title><author>Willing, A.E. ; Walls, E.K. ; Koopmans, H.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-349ab322622fcf5352ed177f1712ea895705bf6a667d82920e2e8ba6a467cfb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body weight</topic><topic>Body Weight - drug effects</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - drug effects</topic><topic>Energy Intake - drug effects</topic><topic>Feeding. Feeding behavior</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High CHO diet</topic><topic>High fat diet</topic><topic>Hypoglycemia</topic><topic>Infusions, Intravenous</topic><topic>Insulin</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Willing, A.E.</creatorcontrib><creatorcontrib>Walls, E.K.</creatorcontrib><creatorcontrib>Koopmans, H.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Willing, A.E.</au><au>Walls, E.K.</au><au>Koopmans, H.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin increases the daily food intake of diabetic rats on high and low fat diets</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>56</volume><issue>5</issue><spage>983</spage><epage>991</epage><pages>983-991</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The effects of insulin dose and diet composition on daily food intake were investigated by IV infusion of insulin in doses of 2 to 5 U/day into diabetic rats consuming either a high CHO or high fat diet. The daily food intake of the diabetic rats on both diets increased significantly over baseline levels (
p < .01) at the low insulin doses and was maintained at these elevated levels through the 5 U/day dose. Insulin increased the rate of weight gain from 1g/day during baseline to 2 and 2.5 g/day in high CHO and high fat fed diabetics (
p < .01). These results show that treatment of diabetic rats with continuous low doses of IV insulin results in a 40% increase in daily food intake regardless of the diet consumed and this increase is accompanied by an increase in rate of body weight gain. While the high fat fed diabetics were relatively hypoglycemic, these increases in intake are not the result of insulin-induced hypoglycemia, since blood glucose concentrations are significantly elevated when the increases occur at the lower insulin doses (
p < .01). Thus, peripheralinsulin infused at physiological levels stimulates rather than inhibits daily food intake.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7824601</pmid><doi>10.1016/0031-9384(94)90333-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Physiology & behavior, 1994-11, Vol.56 (5), p.983-991 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Blood Glucose - metabolism Body weight Body Weight - drug effects Diabetes Diabetes Mellitus, Experimental - physiopathology Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dose-Response Relationship, Drug Eating - drug effects Energy Intake - drug effects Feeding. Feeding behavior Food intake Fundamental and applied biological sciences. Psychology High CHO diet High fat diet Hypoglycemia Infusions, Intravenous Insulin Insulin - pharmacology Male Rats Rats, Inbred Lew Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Insulin increases the daily food intake of diabetic rats on high and low fat diets |
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