Neurite Degeneration Elicited by Apolipoprotein E Peptides
Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apo...
Gespeichert in:
| Veröffentlicht in: | Experimental neurology 1994-11, Vol.130 (1), p.120-126 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 126 |
|---|---|
| container_issue | 1 |
| container_start_page | 120 |
| container_title | Experimental neurology |
| container_volume | 130 |
| creator | Crutcher, Keith A. Clay, Moira A. Scott, Samuel A. Tian, Xintian Tolar, Martin Harmony, Judith A.K. |
| description | Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apoE (amino acids 141-155) were found to be cytotoxic to T lymphocytes in culture. In the present study, tandem presentation of the apoE sequence E141-155, as well as longer monomeric peptides that include this domain, was found to cause extensive and specific degeneration of neurites from embryonic chick sympathetic ganglia in vitro. These results, together with the observation of strong βA4/apoE binding in vitro and the disproportionate occurrence of the ϵ4 allele in both familial and sporadic AD patients, suggest that peptide sequences associated with apoE may contribute directly to neurodegenerative processes. |
| doi_str_mv | 10.1006/exnr.1994.1191 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76944026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014488684711915</els_id><sourcerecordid>76944026</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-5b45141526e70f838218ad76e2b044249c886b09b7ca2cc5a644789099733c793</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EKqWwsiFlQGwp54_GNltVyodUAQPMluNckVGaBDtF9N_jqlU3ppP8Pr579RBySWFMAYpb_G3CmGotxpRqekSGFDTkTHA4JkMAKnKhVHFKzmL8AgAtmByQgVSMciWH5O4F18H3mN3jJzYYbO_bJpvX3qXHKis32bRra9-1XWh79CnK3rDrfYXxnJwsbR3xYj9H5ONh_j57yhevj8-z6SJ3XMs-n5RiQgWdsAIlLBVPl5WtZIGsBCGY0C71K0GX0lnm3MQWQkilQWvJuZOaj8jNbm-q8L3G2JuVjw7r2jbYrqORhRYCWJHA8Q50oY0x4NJ0wa9s2BgKZivLbGWZrSyzlZU-XO03r8sVVgd8byfl1_vcRmfrZbCN8_GAcQGKFyxhaodhsvDjMZjoPDYOKx_Q9aZq_X8N_gBp74Nm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76944026</pqid></control><display><type>article</type><title>Neurite Degeneration Elicited by Apolipoprotein E Peptides</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Crutcher, Keith A. ; Clay, Moira A. ; Scott, Samuel A. ; Tian, Xintian ; Tolar, Martin ; Harmony, Judith A.K.</creator><creatorcontrib>Crutcher, Keith A. ; Clay, Moira A. ; Scott, Samuel A. ; Tian, Xintian ; Tolar, Martin ; Harmony, Judith A.K.</creatorcontrib><description>Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apoE (amino acids 141-155) were found to be cytotoxic to T lymphocytes in culture. In the present study, tandem presentation of the apoE sequence E141-155, as well as longer monomeric peptides that include this domain, was found to cause extensive and specific degeneration of neurites from embryonic chick sympathetic ganglia in vitro. These results, together with the observation of strong βA4/apoE binding in vitro and the disproportionate occurrence of the ϵ4 allele in both familial and sporadic AD patients, suggest that peptide sequences associated with apoE may contribute directly to neurodegenerative processes.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1006/exnr.1994.1191</identifier><identifier>PMID: 7821387</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Apolipoproteins E - chemistry ; Apolipoproteins E - pharmacology ; Biological and medical sciences ; Chick Embryo ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dose-Response Relationship, Drug ; Ganglia, Sympathetic - drug effects ; Medical sciences ; Nerve Degeneration ; Neurites - drug effects ; Neurites - physiology ; Neurology ; Peptide Fragments - chemistry ; Peptide Fragments - pharmacology ; Time Factors</subject><ispartof>Experimental neurology, 1994-11, Vol.130 (1), p.120-126</ispartof><rights>1994 Academic Press</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-5b45141526e70f838218ad76e2b044249c886b09b7ca2cc5a644789099733c793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/exnr.1994.1191$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3408362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7821387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crutcher, Keith A.</creatorcontrib><creatorcontrib>Clay, Moira A.</creatorcontrib><creatorcontrib>Scott, Samuel A.</creatorcontrib><creatorcontrib>Tian, Xintian</creatorcontrib><creatorcontrib>Tolar, Martin</creatorcontrib><creatorcontrib>Harmony, Judith A.K.</creatorcontrib><title>Neurite Degeneration Elicited by Apolipoprotein E Peptides</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apoE (amino acids 141-155) were found to be cytotoxic to T lymphocytes in culture. In the present study, tandem presentation of the apoE sequence E141-155, as well as longer monomeric peptides that include this domain, was found to cause extensive and specific degeneration of neurites from embryonic chick sympathetic ganglia in vitro. These results, together with the observation of strong βA4/apoE binding in vitro and the disproportionate occurrence of the ϵ4 allele in both familial and sporadic AD patients, suggest that peptide sequences associated with apoE may contribute directly to neurodegenerative processes.</description><subject>Animals</subject><subject>Apolipoproteins E - chemistry</subject><subject>Apolipoproteins E - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chick Embryo</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Medical sciences</subject><subject>Nerve Degeneration</subject><subject>Neurites - drug effects</subject><subject>Neurites - physiology</subject><subject>Neurology</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - pharmacology</subject><subject>Time Factors</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EKqWwsiFlQGwp54_GNltVyodUAQPMluNckVGaBDtF9N_jqlU3ppP8Pr579RBySWFMAYpb_G3CmGotxpRqekSGFDTkTHA4JkMAKnKhVHFKzmL8AgAtmByQgVSMciWH5O4F18H3mN3jJzYYbO_bJpvX3qXHKis32bRra9-1XWh79CnK3rDrfYXxnJwsbR3xYj9H5ONh_j57yhevj8-z6SJ3XMs-n5RiQgWdsAIlLBVPl5WtZIGsBCGY0C71K0GX0lnm3MQWQkilQWvJuZOaj8jNbm-q8L3G2JuVjw7r2jbYrqORhRYCWJHA8Q50oY0x4NJ0wa9s2BgKZivLbGWZrSyzlZU-XO03r8sVVgd8byfl1_vcRmfrZbCN8_GAcQGKFyxhaodhsvDjMZjoPDYOKx_Q9aZq_X8N_gBp74Nm</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Crutcher, Keith A.</creator><creator>Clay, Moira A.</creator><creator>Scott, Samuel A.</creator><creator>Tian, Xintian</creator><creator>Tolar, Martin</creator><creator>Harmony, Judith A.K.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>Neurite Degeneration Elicited by Apolipoprotein E Peptides</title><author>Crutcher, Keith A. ; Clay, Moira A. ; Scott, Samuel A. ; Tian, Xintian ; Tolar, Martin ; Harmony, Judith A.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-5b45141526e70f838218ad76e2b044249c886b09b7ca2cc5a644789099733c793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Apolipoproteins E - chemistry</topic><topic>Apolipoproteins E - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chick Embryo</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Medical sciences</topic><topic>Nerve Degeneration</topic><topic>Neurites - drug effects</topic><topic>Neurites - physiology</topic><topic>Neurology</topic><topic>Peptide Fragments - chemistry</topic><topic>Peptide Fragments - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crutcher, Keith A.</creatorcontrib><creatorcontrib>Clay, Moira A.</creatorcontrib><creatorcontrib>Scott, Samuel A.</creatorcontrib><creatorcontrib>Tian, Xintian</creatorcontrib><creatorcontrib>Tolar, Martin</creatorcontrib><creatorcontrib>Harmony, Judith A.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crutcher, Keith A.</au><au>Clay, Moira A.</au><au>Scott, Samuel A.</au><au>Tian, Xintian</au><au>Tolar, Martin</au><au>Harmony, Judith A.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurite Degeneration Elicited by Apolipoprotein E Peptides</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>130</volume><issue>1</issue><spage>120</spage><epage>126</epage><pages>120-126</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Apolipoprotein E (apoE) has been localized to the neurofibrillary tangles and β-amyloid-containing plaques found in the cortex of patients with Alzheimer's disease (AD) (14, 28), suggesting that apoE may play a role in this disorder. Recently, synthetic peptides containing a sequence within apoE (amino acids 141-155) were found to be cytotoxic to T lymphocytes in culture. In the present study, tandem presentation of the apoE sequence E141-155, as well as longer monomeric peptides that include this domain, was found to cause extensive and specific degeneration of neurites from embryonic chick sympathetic ganglia in vitro. These results, together with the observation of strong βA4/apoE binding in vitro and the disproportionate occurrence of the ϵ4 allele in both familial and sporadic AD patients, suggest that peptide sequences associated with apoE may contribute directly to neurodegenerative processes.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>7821387</pmid><doi>10.1006/exnr.1994.1191</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4886 |
| ispartof | Experimental neurology, 1994-11, Vol.130 (1), p.120-126 |
| issn | 0014-4886 1090-2430 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76944026 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apolipoproteins E - chemistry Apolipoproteins E - pharmacology Biological and medical sciences Chick Embryo Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Ganglia, Sympathetic - drug effects Medical sciences Nerve Degeneration Neurites - drug effects Neurites - physiology Neurology Peptide Fragments - chemistry Peptide Fragments - pharmacology Time Factors |
| title | Neurite Degeneration Elicited by Apolipoprotein E Peptides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T15%3A40%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurite%20Degeneration%20Elicited%20by%20Apolipoprotein%20E%20Peptides&rft.jtitle=Experimental%20neurology&rft.au=Crutcher,%20Keith%20A.&rft.date=1994-11-01&rft.volume=130&rft.issue=1&rft.spage=120&rft.epage=126&rft.pages=120-126&rft.issn=0014-4886&rft.eissn=1090-2430&rft.coden=EXNEAC&rft_id=info:doi/10.1006/exnr.1994.1191&rft_dat=%3Cproquest_cross%3E76944026%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76944026&rft_id=info:pmid/7821387&rft_els_id=S0014488684711915&rfr_iscdi=true |