Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation
We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosp...
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| Veröffentlicht in: | Neurobiology of aging 1994-09, Vol.15 (5), p.643-649 |
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| container_title | Neurobiology of aging |
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| creator | Singh, I. Xu, C. Pettegrew, J.W. Kanfer, J.N. |
| description | We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate. |
| doi_str_mv | 10.1016/0197-4580(94)00059-X |
| format | Article |
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Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(94)00059-X</identifier><identifier>PMID: 7824057</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Acetylcholine - biosynthesis ; Aged ; Alkaline Phosphatase - chemistry ; Alzheimer Disease - enzymology ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological and medical sciences ; Brain Chemistry - physiology ; Choline acetyltransferase ; Choline O-Acetyltransferase - antagonists & inhibitors ; Choline O-Acetyltransferase - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Endogenous inhibitor ; Female ; Hippocampus - drug effects ; Hippocampus - enzymology ; Humans ; Hypothalamus - drug effects ; Hypothalamus - enzymology ; Kinetics ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Nerve Tissue Proteins - metabolism ; Neurology ; Phospholipids - metabolism ; phosphomonoester ; Phosphoserine - metabolism ; Phosphoserine - pharmacology</subject><ispartof>Neurobiology of aging, 1994-09, Vol.15 (5), p.643-649</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-53331bf3ecbdf881c12f118f6d5e2c16b1ea7a68067240d7aaf2755d36303b573</citedby><cites>FETCH-LOGICAL-c417t-53331bf3ecbdf881c12f118f6d5e2c16b1ea7a68067240d7aaf2755d36303b573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0197-4580(94)00059-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4250103$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7824057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, I.</creatorcontrib><creatorcontrib>Xu, C.</creatorcontrib><creatorcontrib>Pettegrew, J.W.</creatorcontrib><creatorcontrib>Kanfer, J.N.</creatorcontrib><title>Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate.</description><subject>Acetylcholine - biosynthesis</subject><subject>Aged</subject><subject>Alkaline Phosphatase - chemistry</subject><subject>Alzheimer Disease - enzymology</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - physiology</subject><subject>Choline acetyltransferase</subject><subject>Choline O-Acetyltransferase - antagonists & inhibitors</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Endogenous inhibitor</subject><subject>Female</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - enzymology</subject><subject>Humans</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - enzymology</subject><subject>Kinetics</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurology</subject><subject>Phospholipids - metabolism</subject><subject>phosphomonoester</subject><subject>Phosphoserine - metabolism</subject><subject>Phosphoserine - pharmacology</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9LHDEcxUOp6Gr7H7SQQ6n2MG0y-Tk9FIpoFQQvLXgLmcw33chMsk1mBf3rzbrLHusph_d5X_LeQ-gDJV8pofIboZ1quNDkrONfCCGia-7eoAUVQjeUd-otWuyRI3Rcyn2FFFfyEB0q3XIi1ALFizikvxDTuuAQl6EPc8oFJ4-X68lG7JZpDBGwdTA_jnO2sXjItgBeZSgQ5-rCdnxaQpggnxbcZxvi9406hilEmx9x6gvkBzuHFN-hA2_HAu937wn6c3nx-_yqubn9dX3-86ZxnKq5EYwx2nsGrh-81tTR1lOqvRwEtI7KnoJVVmoiVc0xKGt9q4QYmGSE9UKxE_R5e3eV0781lNlMoTgYRxuhRjVKdpzpVrwKUilbLbmsIN-CLqdSMnizymGq8QwlZrOH2ZRtNmWbjpuXPcxdtX3c3V_3Ewx7026Aqn_a6bY4O_pasAtlj_FWEEpYxX5sMailPQTIprgA0cEQMrjZDCn8_x_PreSovA</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Singh, I.</creator><creator>Xu, C.</creator><creator>Pettegrew, J.W.</creator><creator>Kanfer, J.N.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940901</creationdate><title>Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation</title><author>Singh, I. ; Xu, C. ; Pettegrew, J.W. ; Kanfer, J.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-53331bf3ecbdf881c12f118f6d5e2c16b1ea7a68067240d7aaf2755d36303b573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acetylcholine - biosynthesis</topic><topic>Aged</topic><topic>Alkaline Phosphatase - chemistry</topic><topic>Alzheimer Disease - enzymology</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - physiology</topic><topic>Choline acetyltransferase</topic><topic>Choline O-Acetyltransferase - antagonists & inhibitors</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Endogenous inhibitor</topic><topic>Female</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - enzymology</topic><topic>Humans</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - enzymology</topic><topic>Kinetics</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurology</topic><topic>Phospholipids - metabolism</topic><topic>phosphomonoester</topic><topic>Phosphoserine - metabolism</topic><topic>Phosphoserine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, I.</creatorcontrib><creatorcontrib>Xu, C.</creatorcontrib><creatorcontrib>Pettegrew, J.W.</creatorcontrib><creatorcontrib>Kanfer, J.N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, I.</au><au>Xu, C.</au><au>Pettegrew, J.W.</au><au>Kanfer, J.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>15</volume><issue>5</issue><spage>643</spage><epage>649</epage><pages>643-649</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>7824057</pmid><doi>10.1016/0197-4580(94)00059-X</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetylcholine - biosynthesis Aged Alkaline Phosphatase - chemistry Alzheimer Disease - enzymology Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Brain Chemistry - physiology Choline acetyltransferase Choline O-Acetyltransferase - antagonists & inhibitors Choline O-Acetyltransferase - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Endogenous inhibitor Female Hippocampus - drug effects Hippocampus - enzymology Humans Hypothalamus - drug effects Hypothalamus - enzymology Kinetics Magnetic Resonance Spectroscopy Male Medical sciences Nerve Tissue Proteins - metabolism Neurology Phospholipids - metabolism phosphomonoester Phosphoserine - metabolism Phosphoserine - pharmacology |
| title | Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation |
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