Evaluation of a cytological scoring system for predicting histological grade and disease-free survival in primary breast cancer

A simple cytological scoring system was evaluated as a method of predicting histological grade and disease‐free survival in 79 patients with primary breast cancer. the mitotic activity index and oestrogen receptor status were also assessed for their predictive value. the concordance between cytologi...

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Veröffentlicht in:Cytopathology (Oxford) 1994-10, Vol.5 (5), p.294-300
Hauptverfasser: DE GRAAF, H., WILLEMSE, P., LADDÉ, B. E., VAN DEN BERGEN, H. A., KREBBER, M., TJABBES, T., SLUITER, W. J.
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container_end_page 300
container_issue 5
container_start_page 294
container_title Cytopathology (Oxford)
container_volume 5
creator DE GRAAF, H.
WILLEMSE, P.
LADDÉ, B. E.
VAN DEN BERGEN, H. A.
KREBBER, M.
TJABBES, T.
SLUITER, W. J.
description A simple cytological scoring system was evaluated as a method of predicting histological grade and disease‐free survival in 79 patients with primary breast cancer. the mitotic activity index and oestrogen receptor status were also assessed for their predictive value. the concordance between cytological scores and histological grades was good (80%) for low‐grade lesions, but poor (45%) for high‐grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years. Un système cytologique simple, permettant de prédire le grade histologique et la survie sans récidive, a étéévalué chez 79 patientes avec un cancer mammaire primitif. La valeur prédictive de l'index mitotique et le taux de récepteurs aux oestrogènes a également été testée. La concordance entre les scores cytologiques et les grades histologiques est bonne (80%) pour les tumeurs de bas grade mais mauvaise (45%) pour les tumeurs de haut grade. Des résultats identiques sont obtenus en prenant l'index mitotique comme indicateur pronostique. Le grade cytologique n'est pas un indicateur pronostique indépendent après un suivi moyen de 8 ans. Ein einfaches zytologisches Bewertungssystem wurde hinsichtlich der Vorhersage der histologischen Gradierung und des krankheitsfreien Intervalls in 79 Fällen von Mammacarcinom ausgewertet. Mitoseindex und Östrogenrezeptor‐status wurden berücksichtigt. Die Ûbereinstimmung zwischen zytologischem Wert und histologischer Gradierung war mit 80% gut bei niedermalignen Veränderungen, jedoch schlecht (45%) bei hochmalignen Läsionen. Ähnliche Ergebnisse wurden bei Berücksichtigung des Mitoseindex erzielt. Die zytologische Bewertung erwies sich nicht als unabhängiger prognostischer Indikator nach einer durchschnittlichen Verlaufskontrolle von bis zu 8 Jahren.
doi_str_mv 10.1111/j.1365-2303.1994.tb00433.x
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Mitoseindex und Östrogenrezeptor‐status wurden berücksichtigt. Die Ûbereinstimmung zwischen zytologischem Wert und histologischer Gradierung war mit 80% gut bei niedermalignen Veränderungen, jedoch schlecht (45%) bei hochmalignen Läsionen. Ähnliche Ergebnisse wurden bei Berücksichtigung des Mitoseindex erzielt. 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E.</creatorcontrib><creatorcontrib>VAN DEN BERGEN, H. A.</creatorcontrib><creatorcontrib>KREBBER, M.</creatorcontrib><creatorcontrib>TJABBES, T.</creatorcontrib><creatorcontrib>SLUITER, W. J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytopathology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE GRAAF, H.</au><au>WILLEMSE, P.</au><au>LADDÉ, B. E.</au><au>VAN DEN BERGEN, H. A.</au><au>KREBBER, M.</au><au>TJABBES, T.</au><au>SLUITER, W. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a cytological scoring system for predicting histological grade and disease-free survival in primary breast cancer</atitle><jtitle>Cytopathology (Oxford)</jtitle><addtitle>Cytopathology</addtitle><date>1994-10</date><risdate>1994</risdate><volume>5</volume><issue>5</issue><spage>294</spage><epage>300</epage><pages>294-300</pages><issn>0956-5507</issn><eissn>1365-2303</eissn><abstract>A simple cytological scoring system was evaluated as a method of predicting histological grade and disease‐free survival in 79 patients with primary breast cancer. the mitotic activity index and oestrogen receptor status were also assessed for their predictive value. the concordance between cytological scores and histological grades was good (80%) for low‐grade lesions, but poor (45%) for high‐grade lesions. Similar results were found using the mitotic activity index as a prognostic indicator. Cytological grading was not found to be an independent prognostic indicator after a median follow up of 8 years. Un système cytologique simple, permettant de prédire le grade histologique et la survie sans récidive, a étéévalué chez 79 patientes avec un cancer mammaire primitif. La valeur prédictive de l'index mitotique et le taux de récepteurs aux oestrogènes a également été testée. La concordance entre les scores cytologiques et les grades histologiques est bonne (80%) pour les tumeurs de bas grade mais mauvaise (45%) pour les tumeurs de haut grade. Des résultats identiques sont obtenus en prenant l'index mitotique comme indicateur pronostique. Le grade cytologique n'est pas un indicateur pronostique indépendent après un suivi moyen de 8 ans. Ein einfaches zytologisches Bewertungssystem wurde hinsichtlich der Vorhersage der histologischen Gradierung und des krankheitsfreien Intervalls in 79 Fällen von Mammacarcinom ausgewertet. Mitoseindex und Östrogenrezeptor‐status wurden berücksichtigt. Die Ûbereinstimmung zwischen zytologischem Wert und histologischer Gradierung war mit 80% gut bei niedermalignen Veränderungen, jedoch schlecht (45%) bei hochmalignen Läsionen. Ähnliche Ergebnisse wurden bei Berücksichtigung des Mitoseindex erzielt. Die zytologische Bewertung erwies sich nicht als unabhängiger prognostischer Indikator nach einer durchschnittlichen Verlaufskontrolle von bis zu 8 Jahren.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7819514</pmid><doi>10.1111/j.1365-2303.1994.tb00433.x</doi><tpages>7</tpages></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Biopsy, Needle
breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
Breast Neoplasms - therapy
cytology
Disease-Free Survival
Female
histological grade
Humans
Mastectomy
Middle Aged
Mitosis
mitotic activity index
oestrogen receptor status
Prognosis
Receptors, Estrogen - analysis
Retrospective Studies
title Evaluation of a cytological scoring system for predicting histological grade and disease-free survival in primary breast cancer
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