Acetylcholine receptor and myogenic factor gene expression in Torpedo embryonic development
THE mRNA levels of acetylcholine receptor (AChR) and myogenic factors were followed during embryonic development of Torpedo skeletal muscle and its homologue, the electric organ. A different developmental pattern of AChR gene expression was found in these two tissuesa slight decrease in the muscle,...
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| Veröffentlicht in: | Neuroreport 1994-08, Vol.5 (13), p.1581-1584 |
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| creator | Asher, Orna Fuchs, Sara Souroujon, Miriam C |
| description | THE mRNA levels of acetylcholine receptor (AChR) and myogenic factors were followed during embryonic development of Torpedo skeletal muscle and its homologue, the electric organ. A different developmental pattern of AChR gene expression was found in these two tissuesa slight decrease in the muscle, and a marked increase, concomitant with synapse formation, in the electric organ. However, the developmental pattern of MyoD and MRF4 mRNA levels was similar in both tissues, with no significant changes during development. This is in contrast with the sharp increase in the expression of AChR in the electric organ and may suggest that the burst in the expression of AChR during the differentiation of myotubes into electrocytes is not regulated by changes in the myogenic factor mRNA levels. |
| doi_str_mv | 10.1097/00001756-199408150-00010 |
| format | Article |
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A different developmental pattern of AChR gene expression was found in these two tissuesa slight decrease in the muscle, and a marked increase, concomitant with synapse formation, in the electric organ. However, the developmental pattern of MyoD and MRF4 mRNA levels was similar in both tissues, with no significant changes during development. This is in contrast with the sharp increase in the expression of AChR in the electric organ and may suggest that the burst in the expression of AChR during the differentiation of myotubes into electrocytes is not regulated by changes in the myogenic factor mRNA levels.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199408150-00010</identifier><identifier>PMID: 7819524</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Blotting, Northern ; Development. Senescence. 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A different developmental pattern of AChR gene expression was found in these two tissuesa slight decrease in the muscle, and a marked increase, concomitant with synapse formation, in the electric organ. However, the developmental pattern of MyoD and MRF4 mRNA levels was similar in both tissues, with no significant changes during development. This is in contrast with the sharp increase in the expression of AChR in the electric organ and may suggest that the burst in the expression of AChR during the differentiation of myotubes into electrocytes is not regulated by changes in the myogenic factor mRNA levels.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>DNA Probes</subject><subject>Electric Organ - embryology</subject><subject>Electric Organ - metabolism</subject><subject>Embryo, Nonmammalian</subject><subject>Female</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - physiology</subject><subject>Myogenic Regulatory Factors - genetics</subject><subject>Myogenic Regulatory Factors - metabolism</subject><subject>Receptors, Cholinergic - genetics</subject><subject>Receptors, Cholinergic - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Torpedo - embryology</subject><subject>Torpedo - metabolism</subject><subject>Torpedo ocellata</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQQInRrLOrP8GEg_HWKzBFA8fNxq9kEy9rYuKB0FA4rXTTQo_r_Hu7nXFuRi6EqldVpB4hlLNrzox6zZbDlWwbbgwwzSVr1gh7RDYc1LaRUn9-TDbMSNOAaeVTclnrtwUxjOsLcqE0N1LAhny58Tgfkt_l1I9IC3qc5lyoGwMdDvkrjr2n0fk1tjyQ4q-pYK19Hmk_0vtcJgyZ4tCVQ17ZgD8x5WnAcX5GnkSXKj4_3Vfk09s397fvm7uP7z7c3tw1HtaPexm2EEUIEpTkiosYGWrNujaILhgHPAivTMeE7jwwGZFFCB3oEFQLYLZX5NWx71Tyjz3W2Q599ZiSGzHvq1WtgWVr8r8gbxUDodeO-gj6kmstGO1U-sGVg-XMrgLsXwH2LMD-EbCUvjjN2HcDhnPhaeNL_uUp76p3KRY3-r6eMRACFkcLBkfsIacZS_2e9g9Y7A5dmnf2X_q3vwElGp47</recordid><startdate>19940815</startdate><enddate>19940815</enddate><creator>Asher, Orna</creator><creator>Fuchs, Sara</creator><creator>Souroujon, Miriam C</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19940815</creationdate><title>Acetylcholine receptor and myogenic factor gene expression in Torpedo embryonic development</title><author>Asher, Orna ; Fuchs, Sara ; Souroujon, Miriam C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4150-c5d34f2dd54751712ff0e880b6d2bd9a41d2c79b028bc405fe0f4db48dd764493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Development. 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Psychology</topic><topic>Gene Expression - physiology</topic><topic>Myogenic Regulatory Factors - genetics</topic><topic>Myogenic Regulatory Factors - metabolism</topic><topic>Receptors, Cholinergic - genetics</topic><topic>Receptors, Cholinergic - metabolism</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Torpedo - embryology</topic><topic>Torpedo - metabolism</topic><topic>Torpedo ocellata</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asher, Orna</creatorcontrib><creatorcontrib>Fuchs, Sara</creatorcontrib><creatorcontrib>Souroujon, Miriam C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asher, Orna</au><au>Fuchs, Sara</au><au>Souroujon, Miriam C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetylcholine receptor and myogenic factor gene expression in Torpedo embryonic development</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1994-08-15</date><risdate>1994</risdate><volume>5</volume><issue>13</issue><spage>1581</spage><epage>1584</epage><pages>1581-1584</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>THE mRNA levels of acetylcholine receptor (AChR) and myogenic factors were followed during embryonic development of Torpedo skeletal muscle and its homologue, the electric organ. A different developmental pattern of AChR gene expression was found in these two tissuesa slight decrease in the muscle, and a marked increase, concomitant with synapse formation, in the electric organ. However, the developmental pattern of MyoD and MRF4 mRNA levels was similar in both tissues, with no significant changes during development. This is in contrast with the sharp increase in the expression of AChR in the electric organ and may suggest that the burst in the expression of AChR during the differentiation of myotubes into electrocytes is not regulated by changes in the myogenic factor mRNA levels.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7819524</pmid><doi>10.1097/00001756-199408150-00010</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroreport, 1994-08, Vol.5 (13), p.1581-1584 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Blotting, Northern Development. Senescence. Regeneration. Transplantation DNA Probes Electric Organ - embryology Electric Organ - metabolism Embryo, Nonmammalian Female Freshwater Fundamental and applied biological sciences. Psychology Gene Expression - physiology Myogenic Regulatory Factors - genetics Myogenic Regulatory Factors - metabolism Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism RNA, Messenger - biosynthesis Torpedo - embryology Torpedo - metabolism Torpedo ocellata Vertebrates: nervous system and sense organs |
| title | Acetylcholine receptor and myogenic factor gene expression in Torpedo embryonic development |
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