The stereospecific effects of isoflurane isomers in vivo
The anesthetic potency of racemic isoflurane and the optically pure stereoisomers was examined in rats. The (+) isomer was 53% more potent than the (−) isomer (minimum alveolar concentration ( MAC) = 1.06 ± 0.07% vs. 1.62 ± 0.02%, P < 0.05) . MAC for racemic isoflurane was 1.32 ± 0.03%. Both ster...
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| Veröffentlicht in: | European journal of pharmacology 1994-09, Vol.263 (1), p.25-29 |
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| container_title | European journal of pharmacology |
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| creator | Lysko, Gene S. Robinson, James L. Casto, Rod Ferrone, Ronald A. |
| description | The anesthetic potency of racemic isoflurane and the optically pure stereoisomers was examined in rats. The (+) isomer was 53% more potent than the (−) isomer (minimum alveolar concentration
(
MAC) = 1.06 ± 0.07%
vs. 1.62 ± 0.02%, P < 0.05)
. MAC for racemic isoflurane was
1.32 ± 0.03%. Both stereoisomers and the racemic isoflurane produced similar depression of arterial pressure. However, the (+) isomer blunted the cardiovascular response to a painful stimulus to a greater extent than did an equi-MAC dose of the (−) isomer. These are the first data to describe pharmacological differences between stereoisomers of a volatile anesthetic administered in vivo by the conventional route (inhaled) and measuring the clinically relevant index of anesthesia, MAC. These data are consistent with a receptor-mediated anesthetic mechanism by volatile anesthetics. |
| doi_str_mv | 10.1016/0014-2999(94)90519-3 |
| format | Article |
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(
MAC) = 1.06 ± 0.07%
vs. 1.62 ± 0.02%, P < 0.05)
. MAC for racemic isoflurane was
1.32 ± 0.03%. Both stereoisomers and the racemic isoflurane produced similar depression of arterial pressure. However, the (+) isomer blunted the cardiovascular response to a painful stimulus to a greater extent than did an equi-MAC dose of the (−) isomer. These are the first data to describe pharmacological differences between stereoisomers of a volatile anesthetic administered in vivo by the conventional route (inhaled) and measuring the clinically relevant index of anesthesia, MAC. These data are consistent with a receptor-mediated anesthetic mechanism by volatile anesthetics.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(94)90519-3</identifier><identifier>PMID: 7821359</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Anesthesia Recovery Period ; Anesthesia, Inhalation ; Anesthetic ; Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Dose-Response Relationship, Drug ; Heart Rate - drug effects ; Isoflurane ; Isoflurane - chemistry ; Male ; Medical sciences ; Neuropharmacology ; Pain - prevention & control ; Pharmacology. Drug treatments ; Rat ; Rats ; Rats, Sprague-Dawley ; Receptor ; Stereoisomer ; Stereoisomerism</subject><ispartof>European journal of pharmacology, 1994-09, Vol.263 (1), p.25-29</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-b332bd55ee0d055a85e56d70aca9f325934b1a2178fc9cbf8f58e29077e301c33</citedby><cites>FETCH-LOGICAL-c452t-b332bd55ee0d055a85e56d70aca9f325934b1a2178fc9cbf8f58e29077e301c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299994905193$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4240916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7821359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lysko, Gene S.</creatorcontrib><creatorcontrib>Robinson, James L.</creatorcontrib><creatorcontrib>Casto, Rod</creatorcontrib><creatorcontrib>Ferrone, Ronald A.</creatorcontrib><title>The stereospecific effects of isoflurane isomers in vivo</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The anesthetic potency of racemic isoflurane and the optically pure stereoisomers was examined in rats. The (+) isomer was 53% more potent than the (−) isomer (minimum alveolar concentration
(
MAC) = 1.06 ± 0.07%
vs. 1.62 ± 0.02%, P < 0.05)
. MAC for racemic isoflurane was
1.32 ± 0.03%. Both stereoisomers and the racemic isoflurane produced similar depression of arterial pressure. However, the (+) isomer blunted the cardiovascular response to a painful stimulus to a greater extent than did an equi-MAC dose of the (−) isomer. These are the first data to describe pharmacological differences between stereoisomers of a volatile anesthetic administered in vivo by the conventional route (inhaled) and measuring the clinically relevant index of anesthesia, MAC. These data are consistent with a receptor-mediated anesthetic mechanism by volatile anesthetics.</description><subject>Anesthesia Recovery Period</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthetic</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Heart Rate - drug effects</subject><subject>Isoflurane</subject><subject>Isoflurane - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pain - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor</subject><subject>Stereoisomer</subject><subject>Stereoisomerism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4UeRPRQnXy1zUWQxS9Y8LKeQ5pOMNJu16Rd8N_bumWPnmZgnnlneAi5oHBHgWb3AFSkTCl1o8StAklVyg_IjBa5SiGn7JDM9sgJOY3xCwCkYvKYHOcFo1yqGSlWn5jEDgO2cYPWO28TdA5tF5PWJT62ru6DWePYNhhi4tfJ1m_bM3LkTB3xfKpz8vH8tFq8psv3l7fF4zK1QrIuLTlnZSUlIlQgpSkkyqzKwVijHGdScVFSw2heOKts6QonC2QK8hw5UMv5nFzvcjeh_e4xdrrx0WJdDz-1fdR5pgSFLBtAsQNtaGMM6PQm-MaEH01Bj8L0aEOPNrQS-k-YHvMvp_y-bLDaL02GhvnVNDfRmtoNLqyPe0wwAYqO1x92GA4uth6Djtbj2mLlwyBTV63__49fNhKGDw</recordid><startdate>19940922</startdate><enddate>19940922</enddate><creator>Lysko, Gene S.</creator><creator>Robinson, James L.</creator><creator>Casto, Rod</creator><creator>Ferrone, Ronald A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940922</creationdate><title>The stereospecific effects of isoflurane isomers in vivo</title><author>Lysko, Gene S. ; Robinson, James L. ; Casto, Rod ; Ferrone, Ronald A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-b332bd55ee0d055a85e56d70aca9f325934b1a2178fc9cbf8f58e29077e301c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Anesthesia Recovery Period</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthetic</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Heart Rate - drug effects</topic><topic>Isoflurane</topic><topic>Isoflurane - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pain - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor</topic><topic>Stereoisomer</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lysko, Gene S.</creatorcontrib><creatorcontrib>Robinson, James L.</creatorcontrib><creatorcontrib>Casto, Rod</creatorcontrib><creatorcontrib>Ferrone, Ronald A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lysko, Gene S.</au><au>Robinson, James L.</au><au>Casto, Rod</au><au>Ferrone, Ronald A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The stereospecific effects of isoflurane isomers in vivo</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1994-09-22</date><risdate>1994</risdate><volume>263</volume><issue>1</issue><spage>25</spage><epage>29</epage><pages>25-29</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The anesthetic potency of racemic isoflurane and the optically pure stereoisomers was examined in rats. The (+) isomer was 53% more potent than the (−) isomer (minimum alveolar concentration
(
MAC) = 1.06 ± 0.07%
vs. 1.62 ± 0.02%, P < 0.05)
. MAC for racemic isoflurane was
1.32 ± 0.03%. Both stereoisomers and the racemic isoflurane produced similar depression of arterial pressure. However, the (+) isomer blunted the cardiovascular response to a painful stimulus to a greater extent than did an equi-MAC dose of the (−) isomer. These are the first data to describe pharmacological differences between stereoisomers of a volatile anesthetic administered in vivo by the conventional route (inhaled) and measuring the clinically relevant index of anesthesia, MAC. These data are consistent with a receptor-mediated anesthetic mechanism by volatile anesthetics.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7821359</pmid><doi>10.1016/0014-2999(94)90519-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1994-09, Vol.263 (1), p.25-29 |
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| subjects | Anesthesia Recovery Period Anesthesia, Inhalation Anesthetic Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Blood Pressure - drug effects Dose-Response Relationship, Drug Heart Rate - drug effects Isoflurane Isoflurane - chemistry Male Medical sciences Neuropharmacology Pain - prevention & control Pharmacology. Drug treatments Rat Rats Rats, Sprague-Dawley Receptor Stereoisomer Stereoisomerism |
| title | The stereospecific effects of isoflurane isomers in vivo |
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