Enhancement of depolarization-induced synaptosomal calcium uptake and neurotransmitter release by bay K8644
Ca 2+ uptake into submaximally stimulated synaptosomes was augmented by low concentrations of BAY K8644 (0.1–100 nM). Use of either veratrine or potassium as the depolarizing agent produced similar effects. Stimulated release of aspartate, glutamate and GABA was enhanced over a similar concentration...
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| Veröffentlicht in: | Biochemical pharmacology 1986-07, Vol.35 (13), p.2193-2197 |
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| container_title | Biochemical pharmacology |
| container_volume | 35 |
| creator | White, Elizabeth J. Bradford, H.F. |
| description | Ca
2+ uptake into submaximally stimulated synaptosomes was augmented by low concentrations of BAY K8644 (0.1–100 nM). Use of either veratrine or potassium as the depolarizing agent produced similar effects. Stimulated release of aspartate, glutamate and GABA was enhanced over a similar concentration range of BAY K8644. The extent of synaptosomal depolarization induced by veratrine was not enhanced by BAY K8644. The results are discussed in relation to BAY K8644 activation of voltage-dependent Ca
2+ channels in neural tissue. This is the first report of BAY K8644 acting on synaptosomes at concentrations that correlate to dihydropyridine binding studies. |
| doi_str_mv | 10.1016/0006-2952(86)90591-5 |
| format | Article |
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2+ uptake into submaximally stimulated synaptosomes was augmented by low concentrations of BAY K8644 (0.1–100 nM). Use of either veratrine or potassium as the depolarizing agent produced similar effects. Stimulated release of aspartate, glutamate and GABA was enhanced over a similar concentration range of BAY K8644. The extent of synaptosomal depolarization induced by veratrine was not enhanced by BAY K8644. The results are discussed in relation to BAY K8644 activation of voltage-dependent Ca
2+ channels in neural tissue. This is the first report of BAY K8644 acting on synaptosomes at concentrations that correlate to dihydropyridine binding studies.</description><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>BAY K 8644</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Cardiotonic agents</subject><subject>Cardiovascular system</subject><subject>Cerebral Cortex - cytology</subject><subject>cortex</subject><subject>depolarization</subject><subject>Ethanol - pharmacology</subject><subject>Exact sciences and technology</subject><subject>Glutamates - metabolism</subject><subject>Glutamic Acid</subject><subject>Ion Channels - metabolism</subject><subject>Medical sciences</subject><subject>neurotransmitters</subject><subject>Nicotinic Acids - pharmacology</subject><subject>Nifedipine - analogs & derivatives</subject><subject>Nifedipine - pharmacology</subject><subject>Nimodipine</subject><subject>Norepinephrine - metabolism</subject><subject>Other techniques and industries</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>synaptosomes</subject><subject>Synaptosomes - metabolism</subject><subject>Veratrine - pharmacology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMo43X0HyhkIaKLar6bbgZkGD9wwI2uw2lyinHa9JqkwvXX23ovd-msQvI-OQnPS8hzzt5yxs07xphpRKfFa2vedEx3vNEPyI7bVq7Hxj4kuzPymDwp5ee2tYZfkAuhhLac78jdTfoByeOEqdJ5oAH38wg5_oEa59TEFBaPgZZDgn2dyzzBSD2MPi4TXfYV7pBCCjThkueaIZUp1oqZZhwRCtL-QHs40C_WKPWUPBpgLPjstF6S7x9uvl1_am6_fvx8_f628UqZ2iipZS964wcFQ8u6rhctdEELAcLrLqyREKzTsm0tBK68MBqUlQZ0i2FQ8pK8Os7d5_nXgqW6KRaP4wgJ56W41nTSyvWV-0CulGaKtSuojqDPcykZB7fPcYJ8cJy5rQy3qXWbaWeN-1eG2-a_OM1f-gnD-dLJ_pq_POVQVqnD6s_HcsYst7KT7f2YlMzIFbs6Yri6_R0xu-Ijrt2GmNFXF-b4_-_-BVTpskw</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>White, Elizabeth J.</creator><creator>Bradford, H.F.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19860701</creationdate><title>Enhancement of depolarization-induced synaptosomal calcium uptake and neurotransmitter release by bay K8644</title><author>White, Elizabeth J. ; Bradford, H.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-4353b2b6cf4af7099b27a9d522a2c59d2b6220953778ad14c265a4836a57edf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>BAY K 8644</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Cardiotonic agents</topic><topic>Cardiovascular system</topic><topic>Cerebral Cortex - cytology</topic><topic>cortex</topic><topic>depolarization</topic><topic>Ethanol - pharmacology</topic><topic>Exact sciences and technology</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Ion Channels - metabolism</topic><topic>Medical sciences</topic><topic>neurotransmitters</topic><topic>Nicotinic Acids - pharmacology</topic><topic>Nifedipine - analogs & derivatives</topic><topic>Nifedipine - pharmacology</topic><topic>Nimodipine</topic><topic>Norepinephrine - metabolism</topic><topic>Other techniques and industries</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>synaptosomes</topic><topic>Synaptosomes - metabolism</topic><topic>Veratrine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>White, Elizabeth J.</creatorcontrib><creatorcontrib>Bradford, H.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>White, Elizabeth J.</au><au>Bradford, H.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of depolarization-induced synaptosomal calcium uptake and neurotransmitter release by bay K8644</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>35</volume><issue>13</issue><spage>2193</spage><epage>2197</epage><pages>2193-2197</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>Ca
2+ uptake into submaximally stimulated synaptosomes was augmented by low concentrations of BAY K8644 (0.1–100 nM). Use of either veratrine or potassium as the depolarizing agent produced similar effects. Stimulated release of aspartate, glutamate and GABA was enhanced over a similar concentration range of BAY K8644. The extent of synaptosomal depolarization induced by veratrine was not enhanced by BAY K8644. The results are discussed in relation to BAY K8644 activation of voltage-dependent Ca
2+ channels in neural tissue. This is the first report of BAY K8644 acting on synaptosomes at concentrations that correlate to dihydropyridine binding studies.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2425811</pmid><doi>10.1016/0006-2952(86)90591-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1986-07, Vol.35 (13), p.2193-2197 |
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| language | eng |
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| subjects | 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Animals Applied sciences BAY K 8644 Biological and medical sciences calcium Calcium - metabolism Cardiotonic agents Cardiovascular system Cerebral Cortex - cytology cortex depolarization Ethanol - pharmacology Exact sciences and technology Glutamates - metabolism Glutamic Acid Ion Channels - metabolism Medical sciences neurotransmitters Nicotinic Acids - pharmacology Nifedipine - analogs & derivatives Nifedipine - pharmacology Nimodipine Norepinephrine - metabolism Other techniques and industries Pharmacology. Drug treatments Potassium - pharmacology Rats synaptosomes Synaptosomes - metabolism Veratrine - pharmacology |
| title | Enhancement of depolarization-induced synaptosomal calcium uptake and neurotransmitter release by bay K8644 |
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