Multiple effects of long-term morphine treatment on postsynaptic β-adrenergic receptor function in hippocampus: an intracellular analysis

We previously reported that β-adrenergic receptors are increased in cerebral cortex and hippocampus in rats treated chronically with morphine and subsequently down-regulated after morphine withdrawal [22,23]. The changes in receptor density in hippocampus were accompanied by a corresponding super- a...

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Veröffentlicht in:	Brain research 1994-09, Vol.656 (2), p.309-318
Hauptverfasser:	Ackerman, Janice M., Womble, Mark D., Moises, Hylan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Analgesics Animals Biological and medical sciences Ca 2+-activated potassium afterhyperpolarization Carbachol - pharmacology Chronic morphine Hippocampal slice Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques Isoproterenol - pharmacology Male Medical sciences Membrane Potentials - drug effects Microelectrodes Morphine - pharmacology Morphine withdrawal Neural Conduction - drug effects Neuropharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Potassium - pharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Pyramidal neuron Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Synapses - drug effects Synapses - metabolism β-Adrenoceptor
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