Age-related changes in left ventricular diastolic performance
Previous studies show that the radionuclide-derived indices of left ventricular (LV) diastolic performance are abnormal at rest in many patients with coronary artery disease (CAD), even in those with normal resting ejection fraction (EF) and no prior myocardial infarction. This study examined the ag...
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| Veröffentlicht in: | The American heart journal 1986-07, Vol.112 (1), p.75-78 |
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| creator | Iskandrian, Abdulmassih S Hakki, A-Hamid |
| description | Previous studies show that the radionuclide-derived indices of left ventricular (LV) diastolic performance are abnormal at rest in many patients with coronary artery disease (CAD), even in those with normal resting ejection fraction (EF) and no prior myocardial infarction. This study examined the age-related changes in LV peak filling rate and time to peak filling rate in 65 subjects between the ages of 20 and 75 years with a low likelihood of CAD. All subjects had normal resting EF (≥ 50%), and none had prior infarction. There was a significant age-related decline in resting peak filling rate (
r = −0.47,
p < 0.001) and exercise peak filling rate (
r = −0.52,
p < 0.001), but no age-related effect in the time to peak filling rate. Of the 29 subjects |
| doi_str_mv | 10.1016/0002-8703(86)90681-2 |
| format | Article |
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r = −0.47,
p < 0.001) and exercise peak filling rate (
r = −0.52,
p < 0.001), but no age-related effect in the time to peak filling rate. Of the 29 subjects <50 years of age, 26 (90%) had resting peak filling rate ≥2.5 EDV/sec (3.1 ± 0.6, mean ± SD) compared to 17 of 36 subjects (47%) ≥50 years of age (2.6 ± 0.6) (
p = 0.002). In a subgroup of 28 subjects with a history of hypertension, the age-related effect was more marked than in the remaining 37 subjects without such a history (
r = −0.66 vs −0.33). Thus, the peak filling rate at rest and during exercise decreases with advancing age; the high frequency of observed abnormality in the peak filling rate at rest in patients with CAD may conceivably be related in part to age differences between patients with CAD and the control group.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(86)90681-2</identifier><identifier>PMID: 3728291</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Aging ; Biological and medical sciences ; Coronary Disease - diagnosis ; Coronary Disease - physiopathology ; Diastole ; Exercise Test ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - diagnostic imaging ; Heart - physiology ; Heart - physiopathology ; Heart Function Tests ; Heart Ventricles - physiopathology ; Humans ; Middle Aged ; Myocardial Contraction ; Radionuclide Imaging ; Rest ; Stroke Volume ; Ventricular Function ; Vertebrates: cardiovascular system</subject><ispartof>The American heart journal, 1986-07, Vol.112 (1), p.75-78</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-9b87fe0d53104a1b8b2d0088579725217bdd152fc92e6b75b51350bb9010f0193</citedby><cites>FETCH-LOGICAL-c386t-9b87fe0d53104a1b8b2d0088579725217bdd152fc92e6b75b51350bb9010f0193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-8703(86)90681-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8157428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3728291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iskandrian, Abdulmassih S</creatorcontrib><creatorcontrib>Hakki, A-Hamid</creatorcontrib><title>Age-related changes in left ventricular diastolic performance</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Previous studies show that the radionuclide-derived indices of left ventricular (LV) diastolic performance are abnormal at rest in many patients with coronary artery disease (CAD), even in those with normal resting ejection fraction (EF) and no prior myocardial infarction. This study examined the age-related changes in LV peak filling rate and time to peak filling rate in 65 subjects between the ages of 20 and 75 years with a low likelihood of CAD. All subjects had normal resting EF (≥ 50%), and none had prior infarction. There was a significant age-related decline in resting peak filling rate (
r = −0.47,
p < 0.001) and exercise peak filling rate (
r = −0.52,
p < 0.001), but no age-related effect in the time to peak filling rate. Of the 29 subjects <50 years of age, 26 (90%) had resting peak filling rate ≥2.5 EDV/sec (3.1 ± 0.6, mean ± SD) compared to 17 of 36 subjects (47%) ≥50 years of age (2.6 ± 0.6) (
p = 0.002). In a subgroup of 28 subjects with a history of hypertension, the age-related effect was more marked than in the remaining 37 subjects without such a history (
r = −0.66 vs −0.33). Thus, the peak filling rate at rest and during exercise decreases with advancing age; the high frequency of observed abnormality in the peak filling rate at rest in patients with CAD may conceivably be related in part to age differences between patients with CAD and the control group.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - physiopathology</subject><subject>Diastole</subject><subject>Exercise Test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Heart Function Tests</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Myocardial Contraction</subject><subject>Radionuclide Imaging</subject><subject>Rest</subject><subject>Stroke Volume</subject><subject>Ventricular Function</subject><subject>Vertebrates: cardiovascular system</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKxEAQhhtRdFzeQCEHET1Eqzvp7aAg4gaCFz03vVS0JZOM3ZkB396MM8zRU1HU9xdVHyHHFC4pUHEFAKxUEqpzJS40CEVLtkUmFLQshazrbTLZIHtkP-evsRVMiV2yW0mmmKYTcn37gWXC1g4YCv9puw_MReyKFpuhWGA3pOjnrU1FiDYPfRt9McPU9GlqO4-HZKexbcajdT0g7w_3b3dP5cvr4_Pd7UvpKyWGUjslG4TAKwq1pU45FgCU4lJLxhmVLgTKWeM1Q-Ekd5xWHJzTQKEBqqsDcrbaO0v99xzzYKYxe2xb22E_z0YKXXEN1QjWK9CnPueEjZmlOLXpx1AwS2tmqcQslRglzJ81w8bYyXr_3E0xbEJrTeP8dD232du2SePzMW8wRbmsmRqxmxWGo4tFxGSyjzh6CjGhH0zo4_93_AIK-Ya8</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Iskandrian, Abdulmassih S</creator><creator>Hakki, A-Hamid</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860701</creationdate><title>Age-related changes in left ventricular diastolic performance</title><author>Iskandrian, Abdulmassih S ; Hakki, A-Hamid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-9b87fe0d53104a1b8b2d0088579725217bdd152fc92e6b75b51350bb9010f0193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - physiopathology</topic><topic>Diastole</topic><topic>Exercise Test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Heart Function Tests</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Myocardial Contraction</topic><topic>Radionuclide Imaging</topic><topic>Rest</topic><topic>Stroke Volume</topic><topic>Ventricular Function</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iskandrian, Abdulmassih S</creatorcontrib><creatorcontrib>Hakki, A-Hamid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iskandrian, Abdulmassih S</au><au>Hakki, A-Hamid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in left ventricular diastolic performance</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>112</volume><issue>1</issue><spage>75</spage><epage>78</epage><pages>75-78</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Previous studies show that the radionuclide-derived indices of left ventricular (LV) diastolic performance are abnormal at rest in many patients with coronary artery disease (CAD), even in those with normal resting ejection fraction (EF) and no prior myocardial infarction. This study examined the age-related changes in LV peak filling rate and time to peak filling rate in 65 subjects between the ages of 20 and 75 years with a low likelihood of CAD. All subjects had normal resting EF (≥ 50%), and none had prior infarction. There was a significant age-related decline in resting peak filling rate (
r = −0.47,
p < 0.001) and exercise peak filling rate (
r = −0.52,
p < 0.001), but no age-related effect in the time to peak filling rate. Of the 29 subjects <50 years of age, 26 (90%) had resting peak filling rate ≥2.5 EDV/sec (3.1 ± 0.6, mean ± SD) compared to 17 of 36 subjects (47%) ≥50 years of age (2.6 ± 0.6) (
p = 0.002). In a subgroup of 28 subjects with a history of hypertension, the age-related effect was more marked than in the remaining 37 subjects without such a history (
r = −0.66 vs −0.33). Thus, the peak filling rate at rest and during exercise decreases with advancing age; the high frequency of observed abnormality in the peak filling rate at rest in patients with CAD may conceivably be related in part to age differences between patients with CAD and the control group.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3728291</pmid><doi>10.1016/0002-8703(86)90681-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | The American heart journal, 1986-07, Vol.112 (1), p.75-78 |
| issn | 0002-8703 1097-6744 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aging Biological and medical sciences Coronary Disease - diagnosis Coronary Disease - physiopathology Diastole Exercise Test Fundamental and applied biological sciences. Psychology Heart Heart - diagnostic imaging Heart - physiology Heart - physiopathology Heart Function Tests Heart Ventricles - physiopathology Humans Middle Aged Myocardial Contraction Radionuclide Imaging Rest Stroke Volume Ventricular Function Vertebrates: cardiovascular system |
| title | Age-related changes in left ventricular diastolic performance |
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