An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus
We have investigated long-term synaptic depression in the CA1 region of rat hippocampal slices. Prolonged low-frequency stimulation (LFS; 900 stimuli delivered at 2 Hz) of the Schaffer collateral-commissural pathway in naïve slices did not induce long-term depression (LTD) of synaptic transmission....
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| Veröffentlicht in: | Experimental brain research 1994, Vol.100 (3), p.437-443 |
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| creator | BASHIR, Z. I COLLINGRIDGE, G. L |
| description | We have investigated long-term synaptic depression in the CA1 region of rat hippocampal slices. Prolonged low-frequency stimulation (LFS; 900 stimuli delivered at 2 Hz) of the Schaffer collateral-commissural pathway in naïve slices did not induce long-term depression (LTD) of synaptic transmission. However, if long-term potentiation (LTP) was firstly induced in the pathway then LFS generated an LTD-like effect (i.e. depotentiation of LTP). Depotentiation could be induced 2 h (the longest time studied) after the induction of LTP and was stable for the duration of the experiment (followed for up to 40 min). The induction of depotentiation was not blocked by the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoate, the L-type voltage-gated Ca2+ channel blocker nimodipine or the nitric oxide synthase inhibitor N omega-nitro-L-arginine. However, the magnitude of depotentiation was reversibly reduced, in a stereoselective manner, by the specific metabotropic glutamate receptor (mGluR) antagonist (+)-alpha-methyl-4-carboxyphenylglycine. These results show that prolonged low frequency stimulation can result in an mGluR-dependent depotentiation of LTP. |
| doi_str_mv | 10.1007/BF02738403 |
| format | Article |
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However, the magnitude of depotentiation was reversibly reduced, in a stereoselective manner, by the specific metabotropic glutamate receptor (mGluR) antagonist (+)-alpha-methyl-4-carboxyphenylglycine. These results show that prolonged low frequency stimulation can result in an mGluR-dependent depotentiation of LTP.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/BF02738403</identifier><identifier>PMID: 7813681</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>2-Amino-5-phosphonovalerate - pharmacology ; Animals ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Benzoates - pharmacology ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Electric Stimulation ; Female ; Fundamental and applied biological sciences. Psychology ; Glycine - analogs & derivatives ; Glycine - pharmacology ; Hippocampus - physiology ; Long-Term Potentiation - drug effects ; Long-Term Potentiation - physiology ; Nimodipine - pharmacology ; Nitroarginine ; Rats ; Receptors, Metabotropic Glutamate - antagonists & inhibitors ; Synaptic Transmission - physiology ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Experimental brain research, 1994, Vol.100 (3), p.437-443</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c239t-938561b70d329622673e7493deb310ed749361a6201d066ae5456a1e0c238deb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4245370$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7813681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BASHIR, Z. I</creatorcontrib><creatorcontrib>COLLINGRIDGE, G. L</creatorcontrib><title>An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>We have investigated long-term synaptic depression in the CA1 region of rat hippocampal slices. Prolonged low-frequency stimulation (LFS; 900 stimuli delivered at 2 Hz) of the Schaffer collateral-commissural pathway in naïve slices did not induce long-term depression (LTD) of synaptic transmission. However, if long-term potentiation (LTP) was firstly induced in the pathway then LFS generated an LTD-like effect (i.e. depotentiation of LTP). Depotentiation could be induced 2 h (the longest time studied) after the induction of LTP and was stable for the duration of the experiment (followed for up to 40 min). The induction of depotentiation was not blocked by the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoate, the L-type voltage-gated Ca2+ channel blocker nimodipine or the nitric oxide synthase inhibitor N omega-nitro-L-arginine. However, the magnitude of depotentiation was reversibly reduced, in a stereoselective manner, by the specific metabotropic glutamate receptor (mGluR) antagonist (+)-alpha-methyl-4-carboxyphenylglycine. These results show that prolonged low frequency stimulation can result in an mGluR-dependent depotentiation of LTP.</description><subject>2-Amino-5-phosphonovalerate - pharmacology</subject><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Benzoates - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - pharmacology</subject><subject>Hippocampus - physiology</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Long-Term Potentiation - physiology</subject><subject>Nimodipine - pharmacology</subject><subject>Nitroarginine</subject><subject>Rats</subject><subject>Receptors, Metabotropic Glutamate - antagonists & inhibitors</subject><subject>Synaptic Transmission - physiology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67p68S70IN6qM0matMd18QsWvOi5ZNvZ3Uib1iYV_Pe2WBY8eZmP931mYIaxS4RbBNB394_AtUgliCM2Ryl4jAjqmM0BUMYyxeyUnXn_MbZCw4zNdIpCpThnZuki677IB7szwTYuarZRSW0TyAV7UKrG7eJAXR39cayLwp6i1RKjjnYTOyp727ZNYeq29-fsZGsqTxdTXrD3x4e31XO8fn16WS3XccFFFuJMpInCjYZS8ExxrrQgLTNR0kYgUDnWCo3igCUoZSiRiTJIMIynI7RgN79726757IeD8tr6gqrKOGp6n2uV8WQI_4KoEs1lCgN4NYH9pqYybztbm-47n543-NeTb3xhqm1nXGH9AZNcJsO3xQ-E_XuM</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>BASHIR, Z. I</creator><creator>COLLINGRIDGE, G. L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus</title><author>BASHIR, Z. I ; COLLINGRIDGE, G. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-938561b70d329622673e7493deb310ed749361a6201d066ae5456a1e0c238deb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>2-Amino-5-phosphonovalerate - pharmacology</topic><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Benzoates - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - pharmacology</topic><topic>Hippocampus - physiology</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Long-Term Potentiation - physiology</topic><topic>Nimodipine - pharmacology</topic><topic>Nitroarginine</topic><topic>Rats</topic><topic>Receptors, Metabotropic Glutamate - antagonists & inhibitors</topic><topic>Synaptic Transmission - physiology</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BASHIR, Z. I</creatorcontrib><creatorcontrib>COLLINGRIDGE, G. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BASHIR, Z. I</au><au>COLLINGRIDGE, G. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1994</date><risdate>1994</risdate><volume>100</volume><issue>3</issue><spage>437</spage><epage>443</epage><pages>437-443</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>We have investigated long-term synaptic depression in the CA1 region of rat hippocampal slices. Prolonged low-frequency stimulation (LFS; 900 stimuli delivered at 2 Hz) of the Schaffer collateral-commissural pathway in naïve slices did not induce long-term depression (LTD) of synaptic transmission. However, if long-term potentiation (LTP) was firstly induced in the pathway then LFS generated an LTD-like effect (i.e. depotentiation of LTP). Depotentiation could be induced 2 h (the longest time studied) after the induction of LTP and was stable for the duration of the experiment (followed for up to 40 min). The induction of depotentiation was not blocked by the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoate, the L-type voltage-gated Ca2+ channel blocker nimodipine or the nitric oxide synthase inhibitor N omega-nitro-L-arginine. However, the magnitude of depotentiation was reversibly reduced, in a stereoselective manner, by the specific metabotropic glutamate receptor (mGluR) antagonist (+)-alpha-methyl-4-carboxyphenylglycine. These results show that prolonged low frequency stimulation can result in an mGluR-dependent depotentiation of LTP.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7813681</pmid><doi>10.1007/BF02738403</doi><tpages>7</tpages></addata></record> |
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| subjects | 2-Amino-5-phosphonovalerate - pharmacology Animals Arginine - analogs & derivatives Arginine - pharmacology Benzoates - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electric Stimulation Female Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - pharmacology Hippocampus - physiology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Nimodipine - pharmacology Nitroarginine Rats Receptors, Metabotropic Glutamate - antagonists & inhibitors Synaptic Transmission - physiology Time Factors Vertebrates: nervous system and sense organs |
| title | An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus |
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