Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata

Uterine leiomyomata are thought to be monoclonal neoplasms. Accordingly, investigations of clonality with G6PD isoforms used as a marker for X chromosome inactivation have suggested independent origins for multiple tumors within individual uteri. However, results from a recent study assessing methyl...

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Veröffentlicht in:	Genes chromosomes & cancer 1994-09, Vol.11 (1), p.1-6
Hauptverfasser:	Mashal, Robert D., Fejzo, Marlena L. Schoenberg, Friedman, Andrew J., Mitchner, Natasha, Nowak, Romana A., Rein, Mitchell S., Morton, Cynthia C., Sklar, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles androgen receptors Base Sequence Chromosome Aberrations Clone Cells DNA, Neoplasm - genetics Dosage Compensation, Genetic Female Humans Karyotyping leiomyoma Leiomyomatosis - genetics Leiomyomatosis - pathology man Minisatellite Repeats Molecular Sequence Data Neoplasm Proteins - genetics Neoplastic Stem Cells - chemistry Neoplastic Stem Cells - pathology Polymorphism, Genetic Receptors, Androgen - genetics Repetitive Sequences, Nucleic Acid Tumor Cells, Cultured Uterine Neoplasms - genetics Uterine Neoplasms - pathology X-chromosome inactivation
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