Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) secretion but not IL-6 from activated human peripheral blood monocytes by a new synthetic demethylpodophyllotoxin derivative

A newly synthesized demethylpodophyllotoxin derivative, 4-O-butanoyl-4'-demethylpodophyllotoxin (BDPT) or BN58705, has recently been shown to exert a potent cytotoxic activity in vitro against a variety of drug-resistant human tumor cell lines. The effect of this agent on effector cells of the...

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Veröffentlicht in:	Journal of clinical immunology 1994-09, Vol.14 (5), p.280-288
Hauptverfasser:	Gan, X H, Robin, J P, Huerta, J M, Braquet, P, Bonavida, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Enzyme-Linked Immunosorbent Assay Humans Interleukin-1 - antagonists & inhibitors Interleukin-1 - biosynthesis Interleukin-1 - chemistry Interleukin-6 - biosynthesis Interleukin-6 - chemistry Lymphocyte Activation Lymphocytes - drug effects Lymphocytes - metabolism Mitogens Molecular Sequence Data Monocytes - drug effects Monocytes - metabolism Pentoxifylline - pharmacology Podophyllotoxin - analogs & derivatives Podophyllotoxin - chemical synthesis Podophyllotoxin - pharmacology Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - chemistry
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