Platelet of [3H]paroxetine binding, 5-HT stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder
The present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (SAD) using serotonin (5-HT)-stimulated Ca2+ response as an integrated measure of 5-HT2 receptor function in platelets, [3H]paroxetine binding to characterize the platelet 5-HT transporte...
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| Veröffentlicht in: | Biological psychiatry (1969) 1994-10, Vol.36 (7), p.458-466 |
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| container_title | Biological psychiatry (1969) |
| container_volume | 36 |
| creator | OZAKI, N ROSENTHAL, N. E MAZZOLA, P CHIUEH, C. C HARDIN, T GARCIA-BORREGUERO, D SCHWARTZ, P. J TURNER, E OREN, D. A MURPHY, D. L |
| description | The present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (SAD) using serotonin (5-HT)-stimulated Ca2+ response as an integrated measure of 5-HT2 receptor function in platelets, [3H]paroxetine binding to characterize the platelet 5-HT transporter and 5-HT content as an index of the platelet storage capacity for this neurotransmitter amine. Purified density-dependent subpopulations of platelets in untreated and light-treated SAD patients and matched controls were investigated in order to control for possible variations in platelet turnover. We found no differences between SAD patients and controls on any of the measures, nor between light therapy conditions in SAD patients, although we found a higher Bmax of [3H]paroxetine binding and 5-HT content in heavy platelets compared to light platelets. Although the validity of platelet serotonergic measures as a model for brain serotonergic systems still remains to be elucidated, we found no evidence of platelet serotonergic abnormalities in our sample of SAD patients. |
| doi_str_mv | 10.1016/0006-3223(94)90641-6 |
| format | Article |
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E ; MAZZOLA, P ; CHIUEH, C. C ; HARDIN, T ; GARCIA-BORREGUERO, D ; SCHWARTZ, P. J ; TURNER, E ; OREN, D. A ; MURPHY, D. L</creator><creatorcontrib>OZAKI, N ; ROSENTHAL, N. E ; MAZZOLA, P ; CHIUEH, C. C ; HARDIN, T ; GARCIA-BORREGUERO, D ; SCHWARTZ, P. J ; TURNER, E ; OREN, D. A ; MURPHY, D. L</creatorcontrib><description>The present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (SAD) using serotonin (5-HT)-stimulated Ca2+ response as an integrated measure of 5-HT2 receptor function in platelets, [3H]paroxetine binding to characterize the platelet 5-HT transporter and 5-HT content as an index of the platelet storage capacity for this neurotransmitter amine. Purified density-dependent subpopulations of platelets in untreated and light-treated SAD patients and matched controls were investigated in order to control for possible variations in platelet turnover. We found no differences between SAD patients and controls on any of the measures, nor between light therapy conditions in SAD patients, although we found a higher Bmax of [3H]paroxetine binding and 5-HT content in heavy platelets compared to light platelets. Although the validity of platelet serotonergic measures as a model for brain serotonergic systems still remains to be elucidated, we found no evidence of platelet serotonergic abnormalities in our sample of SAD patients.</description><identifier>ISSN: 0006-3223</identifier><identifier>DOI: 10.1016/0006-3223(94)90641-6</identifier><identifier>PMID: 7811842</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adult ; Adult and adolescent clinical studies ; Binding Sites ; Biological and medical sciences ; Blood Platelets - metabolism ; Calcium - metabolism ; Depression ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Paroxetine - metabolism ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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L</creatorcontrib><title>Platelet of [3H]paroxetine binding, 5-HT stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>The present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (SAD) using serotonin (5-HT)-stimulated Ca2+ response as an integrated measure of 5-HT2 receptor function in platelets, [3H]paroxetine binding to characterize the platelet 5-HT transporter and 5-HT content as an index of the platelet storage capacity for this neurotransmitter amine. Purified density-dependent subpopulations of platelets in untreated and light-treated SAD patients and matched controls were investigated in order to control for possible variations in platelet turnover. We found no differences between SAD patients and controls on any of the measures, nor between light therapy conditions in SAD patients, although we found a higher Bmax of [3H]paroxetine binding and 5-HT content in heavy platelets compared to light platelets. Although the validity of platelet serotonergic measures as a model for brain serotonergic systems still remains to be elucidated, we found no evidence of platelet serotonergic abnormalities in our sample of SAD patients.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>Calcium - metabolism</subject><subject>Depression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Paroxetine - metabolism</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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C</creator><creator>HARDIN, T</creator><creator>GARCIA-BORREGUERO, D</creator><creator>SCHWARTZ, P. J</creator><creator>TURNER, E</creator><creator>OREN, D. A</creator><creator>MURPHY, D. L</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941001</creationdate><title>Platelet of [3H]paroxetine binding, 5-HT stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder</title><author>OZAKI, N ; ROSENTHAL, N. E ; MAZZOLA, P ; CHIUEH, C. C ; HARDIN, T ; GARCIA-BORREGUERO, D ; SCHWARTZ, P. J ; TURNER, E ; OREN, D. A ; MURPHY, D. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-a82d1e7d026b7f0b8e1c4a9c57bf3ab40e77547c3ec4ba33bc1e0ff93e11d8a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>Calcium - metabolism</topic><topic>Depression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Paroxetine - metabolism</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Seasonal Affective Disorder - metabolism</topic><topic>Seasonal Affective Disorder - psychology</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OZAKI, N</creatorcontrib><creatorcontrib>ROSENTHAL, N. E</creatorcontrib><creatorcontrib>MAZZOLA, P</creatorcontrib><creatorcontrib>CHIUEH, C. C</creatorcontrib><creatorcontrib>HARDIN, T</creatorcontrib><creatorcontrib>GARCIA-BORREGUERO, D</creatorcontrib><creatorcontrib>SCHWARTZ, P. J</creatorcontrib><creatorcontrib>TURNER, E</creatorcontrib><creatorcontrib>OREN, D. A</creatorcontrib><creatorcontrib>MURPHY, D. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet of [3H]paroxetine binding, 5-HT stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1994-10-01</date><risdate>1994</risdate><volume>36</volume><issue>7</issue><spage>458</spage><epage>466</epage><pages>458-466</pages><issn>0006-3223</issn><coden>BIPCBF</coden><abstract>The present study was designed to evaluate cellular serotonergic functions in winter seasonal affective disorder (SAD) using serotonin (5-HT)-stimulated Ca2+ response as an integrated measure of 5-HT2 receptor function in platelets, [3H]paroxetine binding to characterize the platelet 5-HT transporter and 5-HT content as an index of the platelet storage capacity for this neurotransmitter amine. Purified density-dependent subpopulations of platelets in untreated and light-treated SAD patients and matched controls were investigated in order to control for possible variations in platelet turnover. We found no differences between SAD patients and controls on any of the measures, nor between light therapy conditions in SAD patients, although we found a higher Bmax of [3H]paroxetine binding and 5-HT content in heavy platelets compared to light platelets. Although the validity of platelet serotonergic measures as a model for brain serotonergic systems still remains to be elucidated, we found no evidence of platelet serotonergic abnormalities in our sample of SAD patients.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>7811842</pmid><doi>10.1016/0006-3223(94)90641-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 1994-10, Vol.36 (7), p.458-466 |
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| subjects | Adult Adult and adolescent clinical studies Binding Sites Biological and medical sciences Blood Platelets - metabolism Calcium - metabolism Depression Female Humans Male Medical sciences Middle Aged Mood disorders Paroxetine - metabolism Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Seasonal Affective Disorder - metabolism Seasonal Affective Disorder - psychology Serotonin - metabolism |
| title | Platelet of [3H]paroxetine binding, 5-HT stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder |
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