Somatostatin effects on the cyclic AMP system and lipid metabolism in mouse brain
The effect of somatostatin on cyclic AMP-protein kinase system and lipid metabolism was studied in mouse brain. Subcutaneous injection of the peptide decreased the cyclic AMP and cyclic GMP levels (70% and 60% respectively) as well as protein kinase and triglyceride lipase activities (30%). Cyclic A...
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| Veröffentlicht in: | Neurochemical research 1986-04, Vol.11 (4), p.497-504 |
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| container_title | Neurochemical research |
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| creator | CATALAN, R. E MARTINEZ, A. M MIGUEL, B. G ROBLES, A ARAGONES, M. D |
| description | The effect of somatostatin on cyclic AMP-protein kinase system and lipid metabolism was studied in mouse brain. Subcutaneous injection of the peptide decreased the cyclic AMP and cyclic GMP levels (70% and 60% respectively) as well as protein kinase and triglyceride lipase activities (30%). Cyclic AMP binding protein activity was not affected. Experiments carried out with [14C]acetate as precursor of lipids seem to indicate that somatostatin blocks the fatty acid turnover. On the other hand, the general decrease of 32P incorporation into all phospholipids by somatostatin suggests that the peptide interferes with the precursor uptake into phospholipids. The findings reported here indicate that somatostatin has a role on brain metabolism and further add more data in support for its neuromodulating action. |
| doi_str_mv | 10.1007/BF00965319 |
| format | Article |
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The findings reported here indicate that somatostatin has a role on brain metabolism and further add more data in support for its neuromodulating action.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/BF00965319</identifier><identifier>PMID: 2873518</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Acetates - metabolism ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; brain ; Brain Chemistry - drug effects ; Carrier Proteins - metabolism ; Central nervous system ; Cerebral Cortex - metabolism ; cyclic AMP ; Cyclic AMP - metabolism ; Cyclic AMP Receptor Protein ; Cyclic GMP - metabolism ; Fundamental and applied biological sciences. 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E</creatorcontrib><creatorcontrib>MARTINEZ, A. M</creatorcontrib><creatorcontrib>MIGUEL, B. G</creatorcontrib><creatorcontrib>ROBLES, A</creatorcontrib><creatorcontrib>ARAGONES, M. D</creatorcontrib><title>Somatostatin effects on the cyclic AMP system and lipid metabolism in mouse brain</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>The effect of somatostatin on cyclic AMP-protein kinase system and lipid metabolism was studied in mouse brain. Subcutaneous injection of the peptide decreased the cyclic AMP and cyclic GMP levels (70% and 60% respectively) as well as protein kinase and triglyceride lipase activities (30%). Cyclic AMP binding protein activity was not affected. Experiments carried out with [14C]acetate as precursor of lipids seem to indicate that somatostatin blocks the fatty acid turnover. On the other hand, the general decrease of 32P incorporation into all phospholipids by somatostatin suggests that the peptide interferes with the precursor uptake into phospholipids. The findings reported here indicate that somatostatin has a role on brain metabolism and further add more data in support for its neuromodulating action.</description><subject>Acetates - metabolism</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Brain Chemistry - drug effects</subject><subject>Carrier Proteins - metabolism</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - metabolism</subject><subject>cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP Receptor Protein</subject><subject>Cyclic GMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>growth hormone-release inhibiting hormone</subject><subject>Injections, Subcutaneous</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Phospholipids - metabolism</subject><subject>Somatostatin - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVYv3oUcxIOwmmy-do-1WBUqKup5mU2yGNns1k166L83paUevczAzDMvw4PQOSU3lBB1ezcnpJSC0fIAjalQLJMlYYdoTJjkWRqTY3QSwjchCc_pCI3yQjFBizF6e-89xD5EiK7DtmmsjgH3HY5fFuu1bp3G0-dXHNYhWo-hM7h1S2ewtxHqvnXB43To-1WwuB7AdafoqIE22LNdn6DP-f3H7DFbvDw8zaaLTDOex0wSJQgxslY250XJNYfCMMilNA0A1HnDOBOpSsNBcsWoUYppbrmwVDPGJuhqm7sc-p-VDbHyLmjbttDZ9E2lZEkVKcW_IOWsJBtrE3S9BfXQhzDYploOzsOwriipNqKrP9EJvtilrmpvzR7dmU37y90egoa2GaDTLuyxQslCpKRfwFaDVA</recordid><startdate>19860401</startdate><enddate>19860401</enddate><creator>CATALAN, R. 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D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-607500d6b7e24894c4a8d3a266dfaaab2f34352f36d4a64731d773c4e45e1c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acetates - metabolism</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Brain Chemistry - drug effects</topic><topic>Carrier Proteins - metabolism</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - metabolism</topic><topic>cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP Receptor Protein</topic><topic>Cyclic GMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>growth hormone-release inhibiting hormone</topic><topic>Injections, Subcutaneous</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Phospholipids - metabolism</topic><topic>Somatostatin - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CATALAN, R. E</creatorcontrib><creatorcontrib>MARTINEZ, A. M</creatorcontrib><creatorcontrib>MIGUEL, B. G</creatorcontrib><creatorcontrib>ROBLES, A</creatorcontrib><creatorcontrib>ARAGONES, M. 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D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin effects on the cyclic AMP system and lipid metabolism in mouse brain</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>11</volume><issue>4</issue><spage>497</spage><epage>504</epage><pages>497-504</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>The effect of somatostatin on cyclic AMP-protein kinase system and lipid metabolism was studied in mouse brain. Subcutaneous injection of the peptide decreased the cyclic AMP and cyclic GMP levels (70% and 60% respectively) as well as protein kinase and triglyceride lipase activities (30%). Cyclic AMP binding protein activity was not affected. Experiments carried out with [14C]acetate as precursor of lipids seem to indicate that somatostatin blocks the fatty acid turnover. On the other hand, the general decrease of 32P incorporation into all phospholipids by somatostatin suggests that the peptide interferes with the precursor uptake into phospholipids. The findings reported here indicate that somatostatin has a role on brain metabolism and further add more data in support for its neuromodulating action.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2873518</pmid><doi>10.1007/BF00965319</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neurochemical research, 1986-04, Vol.11 (4), p.497-504 |
| issn | 0364-3190 1573-6903 |
| language | eng |
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| subjects | Acetates - metabolism Animals Biochemistry and metabolism Biological and medical sciences brain Brain Chemistry - drug effects Carrier Proteins - metabolism Central nervous system Cerebral Cortex - metabolism cyclic AMP Cyclic AMP - metabolism Cyclic AMP Receptor Protein Cyclic GMP - metabolism Fundamental and applied biological sciences. Psychology growth hormone-release inhibiting hormone Injections, Subcutaneous Lipid Metabolism Male Mice Mice, Inbred Strains Phospholipids - metabolism Somatostatin - pharmacology Vertebrates: nervous system and sense organs |
| title | Somatostatin effects on the cyclic AMP system and lipid metabolism in mouse brain |
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