Genetic Mapping of the Batten Disease Locus (CLN3) to the Interval D16S288-D16S383 by Analysis of Haplotypes and Allelic Association

CLN3, the gene for juvenile-onset neuronal ceroid lipofuscinosis (JNCL) or Batten disease, has been localized by genetic linkage analysis to chromosome 16p between loci D16S297 and D16S57. We have now further refined the localization of CLN3 by haplotype analysis using two new microsatellite markers...

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Veröffentlicht in:	Genomics 1994-07, Vol.22 (2), p.465-468
Hauptverfasser:	Mitchison, Hannah M., Taschner, Peter E.M., O'Rawe, Angela M., de Vos, Nanneke, Phillips, Hilary A., Thompson, Andrew D., Kozman, Helen M., Haines, Jonathan L., Schlumpf, Karen, D'Arigo, Kenneth, Boustany, Rose-Mary N., Callen, David F., Breuning, Martijn H., Gardiner, R.Mark, Mole, Sara E., Lerner, Terry J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Chromosome Mapping Chromosomes, Human, Pair 16 Crossing Over, Genetic DNA, Satellite - genetics Errors of metabolism GENES GENETIC MAPPING Genetic Markers Haplotypes - genetics HUMAN CHROMOSOME 16 Humans Linkage Disequilibrium Lipids (lysosomal enzyme disorders, storage diseases) Male Medical sciences METABOLIC DISEASES Molecular Sequence Data Neuronal Ceroid-Lipofuscinoses - genetics Recombination, Genetic SPHINGOMYELINS
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