Lipoprotein(a) Serum Levels in Post-Menopausal Women Treated with Oral Estrogens Administered at Different Times
Summary The different effects on serum lipoprotein(a) [Lp(a)] levels by administering estrogens at different times of the day (8 a.m. and 8 p.m.) were evaluated in twenty-four post-menopausal women. Patients were assigned to one of the two treatment groups by random sampling numbers. Patients of bot...
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| Veröffentlicht in: | Hormone and metabolic research 1994-08, Vol.26 (8), p.379-382 |
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| container_title | Hormone and metabolic research |
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| creator | Caruso, M. Gabriella Berloco, P. Notarnicola, Maria Di Leo, A. |
| description | Summary
The different effects on serum lipoprotein(a) [Lp(a)] levels by administering estrogens at different times of the day (8 a.m. and 8 p.m.) were evaluated in twenty-four post-menopausal women. Patients were assigned to one of the two treatment groups by random sampling numbers. Patients of both groups received 0.625 mg conjugated equine estrogens daily per os for 21 days. Group A patients (n: 9) received the pill at 8 a.m., and group B patients (n: 12) received the pill at 8 p.m. There were no statistically significant differences between the two treatment groups as regards the anthropometric characteristics, the basal values of the Lp(a), the sex steroid and pituitary hormone levels. Administration of conjugated equine estrogens resulted in decreased levels of Lp(a) only in group B after treatment. The different Lp(a) behaviour in the two groups and in the presence of the same serum hormonal levels, seems to be dependent on the existence of a circadian rhythm of the hepatic responsiveness to estrogens, whose expression is higher during evening hours. |
| doi_str_mv | 10.1055/s-2007-1001711 |
| format | Article |
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The different effects on serum lipoprotein(a) [Lp(a)] levels by administering estrogens at different times of the day (8 a.m. and 8 p.m.) were evaluated in twenty-four post-menopausal women. Patients were assigned to one of the two treatment groups by random sampling numbers. Patients of both groups received 0.625 mg conjugated equine estrogens daily per os for 21 days. Group A patients (n: 9) received the pill at 8 a.m., and group B patients (n: 12) received the pill at 8 p.m. There were no statistically significant differences between the two treatment groups as regards the anthropometric characteristics, the basal values of the Lp(a), the sex steroid and pituitary hormone levels. Administration of conjugated equine estrogens resulted in decreased levels of Lp(a) only in group B after treatment. The different Lp(a) behaviour in the two groups and in the presence of the same serum hormonal levels, seems to be dependent on the existence of a circadian rhythm of the hepatic responsiveness to estrogens, whose expression is higher during evening hours.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1001711</identifier><identifier>PMID: 7806134</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Biological and medical sciences ; Circadian Rhythm ; Estrogen Replacement Therapy ; Estrogens, Conjugated (USP) - administration & dosage ; Female ; Hormones. Endocrine system ; Humans ; Lipoprotein(a) - blood ; Lipoproteins, LDL - metabolism ; Medical sciences ; Middle Aged ; Originals Clinical ; Pharmacology. Drug treatments ; Postmenopause - blood ; Receptors, LDL - metabolism</subject><ispartof>Hormone and metabolic research, 1994-08, Vol.26 (8), p.379-382</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2721-16005f7aa853b3d568e4cbbbf16cf42b71d4e45961c4fb1e028b16ff3b1101983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1001711.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>315,782,786,3021,3022,27933,27934,54568</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4223674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7806134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caruso, M. Gabriella</creatorcontrib><creatorcontrib>Berloco, P.</creatorcontrib><creatorcontrib>Notarnicola, Maria</creatorcontrib><creatorcontrib>Di Leo, A.</creatorcontrib><title>Lipoprotein(a) Serum Levels in Post-Menopausal Women Treated with Oral Estrogens Administered at Different Times</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
The different effects on serum lipoprotein(a) [Lp(a)] levels by administering estrogens at different times of the day (8 a.m. and 8 p.m.) were evaluated in twenty-four post-menopausal women. Patients were assigned to one of the two treatment groups by random sampling numbers. Patients of both groups received 0.625 mg conjugated equine estrogens daily per os for 21 days. Group A patients (n: 9) received the pill at 8 a.m., and group B patients (n: 12) received the pill at 8 p.m. There were no statistically significant differences between the two treatment groups as regards the anthropometric characteristics, the basal values of the Lp(a), the sex steroid and pituitary hormone levels. Administration of conjugated equine estrogens resulted in decreased levels of Lp(a) only in group B after treatment. The different Lp(a) behaviour in the two groups and in the presence of the same serum hormonal levels, seems to be dependent on the existence of a circadian rhythm of the hepatic responsiveness to estrogens, whose expression is higher during evening hours.</description><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens, Conjugated (USP) - administration & dosage</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Originals Clinical</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause - blood</subject><subject>Receptors, LDL - metabolism</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EKkvhyg3JB4Tg4OJxHCc5VqV8SIuKxCKOkZOMqavETj0OiH9PVhv1xmk8M49fyw9jL0FegCzL9ySUlJUAKaECeMR2oItGaFWbx2y3DmtRSl08Zc-I7tZWN6DP2FlVSwOF3rF57-c4p5jRh7f2Hf-OaZn4Hn_jSNwH_i1SFl8xxNkuZEf-M04Y-CGhzTjwPz7f8pu0zq8pp_gLA_HLYfLBU8a0AjbzD9659RwyP_gJ6Tl74uxI-GKr5-zHx-vD1Wexv_n05epyL3pVKRBgpCxdZW1dFl0xlKZG3Xdd58D0TquugkGjLhsDvXYdoFR1B8a5ogOQ0NTFOXtzyl0_d78g5Xby1OM42oBxobYyDSiAI3hxAvsUiRK6dk5-sulvC7I9Km6pPSpuN8XrhVdb8tJNODzgm9N1_3rbW-rt6JINvacHTCtVmOqIiROWbz1O2N7FJYXVyP-e_QdMvJFM</recordid><startdate>199408</startdate><enddate>199408</enddate><creator>Caruso, M. Gabriella</creator><creator>Berloco, P.</creator><creator>Notarnicola, Maria</creator><creator>Di Leo, A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199408</creationdate><title>Lipoprotein(a) Serum Levels in Post-Menopausal Women Treated with Oral Estrogens Administered at Different Times</title><author>Caruso, M. Gabriella ; Berloco, P. ; Notarnicola, Maria ; Di Leo, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2721-16005f7aa853b3d568e4cbbbf16cf42b71d4e45961c4fb1e028b16ff3b1101983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens, Conjugated (USP) - administration & dosage</topic><topic>Female</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Lipoprotein(a) - blood</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Originals Clinical</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause - blood</topic><topic>Receptors, LDL - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caruso, M. Gabriella</creatorcontrib><creatorcontrib>Berloco, P.</creatorcontrib><creatorcontrib>Notarnicola, Maria</creatorcontrib><creatorcontrib>Di Leo, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caruso, M. Gabriella</au><au>Berloco, P.</au><au>Notarnicola, Maria</au><au>Di Leo, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein(a) Serum Levels in Post-Menopausal Women Treated with Oral Estrogens Administered at Different Times</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1994-08</date><risdate>1994</risdate><volume>26</volume><issue>8</issue><spage>379</spage><epage>382</epage><pages>379-382</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
The different effects on serum lipoprotein(a) [Lp(a)] levels by administering estrogens at different times of the day (8 a.m. and 8 p.m.) were evaluated in twenty-four post-menopausal women. Patients were assigned to one of the two treatment groups by random sampling numbers. Patients of both groups received 0.625 mg conjugated equine estrogens daily per os for 21 days. Group A patients (n: 9) received the pill at 8 a.m., and group B patients (n: 12) received the pill at 8 p.m. There were no statistically significant differences between the two treatment groups as regards the anthropometric characteristics, the basal values of the Lp(a), the sex steroid and pituitary hormone levels. Administration of conjugated equine estrogens resulted in decreased levels of Lp(a) only in group B after treatment. The different Lp(a) behaviour in the two groups and in the presence of the same serum hormonal levels, seems to be dependent on the existence of a circadian rhythm of the hepatic responsiveness to estrogens, whose expression is higher during evening hours.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>7806134</pmid><doi>10.1055/s-2007-1001711</doi><tpages>4</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 1994-08, Vol.26 (8), p.379-382 |
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| source | Thieme - Connect here FIRST to enable access; MEDLINE |
| subjects | Biological and medical sciences Circadian Rhythm Estrogen Replacement Therapy Estrogens, Conjugated (USP) - administration & dosage Female Hormones. Endocrine system Humans Lipoprotein(a) - blood Lipoproteins, LDL - metabolism Medical sciences Middle Aged Originals Clinical Pharmacology. Drug treatments Postmenopause - blood Receptors, LDL - metabolism |
| title | Lipoprotein(a) Serum Levels in Post-Menopausal Women Treated with Oral Estrogens Administered at Different Times |
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