Autoregulation of Alimentary and Hepatic Ketogenesis in Sheep

To determine the mechanism of autoregulation of ketogenesis, β-hydroxybutyrate was infused into 5 normal; 3 diabetic, insulin-treated; and 3 diabetic, untreated anesthetized sheep. Net flux of fatty acids, acetoacetate, β-hydroxybutyrate, and insulin were measured across splanchnic tissues by multip...

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Veröffentlicht in:Journal of dairy science 1986-05, Vol.69 (5), p.1270-1281
Hauptverfasser: Heitmann, R.N., Fernandez, J.M.
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description To determine the mechanism of autoregulation of ketogenesis, β-hydroxybutyrate was infused into 5 normal; 3 diabetic, insulin-treated; and 3 diabetic, untreated anesthetized sheep. Net flux of fatty acids, acetoacetate, β-hydroxybutyrate, and insulin were measured across splanchnic tissues by multiplying veno arterial differences by blood flow. β-hydroxybutyrate depressed fatty acid concentrations and hepatic uptake. This decrease in hepatic uptake was not due solely to decreased concentrations, because hepatic extraction decreased 40% in normal and insulin-treated sheep. Portal-drained visceral release of acetoacetate was increased by β-hydroxybutyrate infusion in normal and insulin-treated sheep, but this was associated with even larger increases in hepatic uptake, resulting in decreased total splanchnic release. Portal-drained viscera switched from release to uptake of β-hydroxybutyrate in both normal and insulin-treated animals, but hepatic release increased slightly in normal sheep. β-hydroxybutyrate increased insulin concentration, pancreatic production, and hepatic uptake. Because effects of ketone infusion on net fluxes of fatty acids, acetoacetate, and β-hydroxybutyrate were similar in normal and diabetic, insulin-treated sheep but were diminished or totally absent in diabetic, untreated animals, the mechanism of autoregulation of ketogenesis may be mediated at the insulin receptor or at the site of hepatic fatty acid uptake.
doi_str_mv 10.3168/jds.S0022-0302(86)80533-1
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Net flux of fatty acids, acetoacetate, β-hydroxybutyrate, and insulin were measured across splanchnic tissues by multiplying veno arterial differences by blood flow. β-hydroxybutyrate depressed fatty acid concentrations and hepatic uptake. This decrease in hepatic uptake was not due solely to decreased concentrations, because hepatic extraction decreased 40% in normal and insulin-treated sheep. Portal-drained visceral release of acetoacetate was increased by β-hydroxybutyrate infusion in normal and insulin-treated sheep, but this was associated with even larger increases in hepatic uptake, resulting in decreased total splanchnic release. Portal-drained viscera switched from release to uptake of β-hydroxybutyrate in both normal and insulin-treated animals, but hepatic release increased slightly in normal sheep. β-hydroxybutyrate increased insulin concentration, pancreatic production, and hepatic uptake. Because effects of ketone infusion on net fluxes of fatty acids, acetoacetate, and β-hydroxybutyrate were similar in normal and diabetic, insulin-treated sheep but were diminished or totally absent in diabetic, untreated animals, the mechanism of autoregulation of ketogenesis may be mediated at the insulin receptor or at the site of hepatic fatty acid uptake.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3522682</pmid><doi>10.3168/jds.S0022-0302(86)80533-1</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0022-0302
ispartof Journal of dairy science, 1986-05, Vol.69 (5), p.1270-1281
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subjects 3-Hydroxybutyric Acid
ACETOACETATE
ACETOACETATES
Acetoacetates - blood
ACETOACETATOS
ACIDE GRAS
ACIDOS GRASOS
AETIOLOGY
Animals
APPAREIL DIGESTIF
CETOGENESE
CETOGENESIS
CETONAS
CETONE
CETOSE
CETOSIS
DIABETE
DIABETES
Diabetes Mellitus - blood
Diabetes Mellitus - metabolism
Diabetes Mellitus - veterinary
DIGESTIVE SYSTEM
ETIOLOGIA
ETIOLOGIE
FATTY ACIDS
Fatty Acids, Nonesterified - blood
Female
FISIOLOGIA
FOIE
HIGADO
Homeostasis
HYDROXYBUTYRATE
Hydroxybutyrates - blood
Hydroxybutyrates - pharmacology
INSULIN
Insulin - blood
INSULINA
INSULINE
Intestines - metabolism
KETOGENESIS
Ketone Bodies - biosynthesis
KETONES
KETOSIS
LIVER
Liver - metabolism
OVIN
OVINOS
PHYSIOLOGIE
PHYSIOLOGY
SHEEP
Sheep - metabolism
SISTEMA DIGESTIVO
title Autoregulation of Alimentary and Hepatic Ketogenesis in Sheep
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