Use of the activated coagulation time and heparin dose-response curve for the determination of protamine dosage in vascular surgery

The activated coagulation time (ACT) can be used to construct a two-point heparin dose-response cuirve (HDRC) from the ACT values at baseline and 5 minutes after heparin administration. The ACT value at any subsequent time interval can then be used to estimate the residual heparin activity from the...

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