Circulating Insulin-Like Growth Factor Binding Proteins (IGFBPs) 1 and 2 Induced in Vitamin C-Deficient or Fasted Guinea Pigs Inhibit IGF-I Action in Cultured Cells

Abstract Collagen gene expression and proteoglycan synthesis are decreased in vitamin C-deficient guinea pigs losing weight and in fasted guinea pigs receiving ascorbate. Sera from such guinea pigs contain an insulin-like growth factor (IGF)-I-reversible inhibitor of collagen, proteoglycan and DNA s...

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Veröffentlicht in:	Growth factors (Chur, Switzerland) Switzerland), 1994, Vol.10 (4), p.229-241
Hauptverfasser:	Peterkofsky, Beverly, Gosiewska, Anna, Kipp, Deborah E., Shah, Varsha, Wilson, Shirley
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals ascorbate Ascorbic Acid Deficiency - blood Carrier Proteins - blood Carrier Proteins - isolation & purification Carrier Proteins - pharmacology collagen Collagen - biosynthesis Collagen - genetics DNA - biosynthesis Fasting - blood Gene Expression - drug effects Guinea Pigs Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor I - antagonists & inhibitors Insulin-Like Growth Factor I - pharmacology insulin-like growth factors Mice mitogenesis nutrition Proteoglycans - biosynthesis Rats Somatomedins - metabolism
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