NEW CHLORINE-CONTAINING PRENYLATED C6-C3 COMPOUNDS INCREASING CHOLINE ACETYLTRANSFERASE (ChAT) ACTIVITY IN CULTURE OF POSTNATAL RAT SEPTAL NEURONS FROM ILLICIUM TASHIROI

The structures of two new chlorine-containing C6-C3 compounds isolated from the woods of Illicium tashiroi have been established as 2(R)-12-chloro-2, 3-dihydroillicinone E (1) and 12-chloroillicinone E (2) by X-ray crystallographic analysis and spectroscopic data, respectively. Compound 1 has been f...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1994/10/15, Vol.42(10), pp.2199-2201
Hauptverfasser:	FUKUYAMA, Yoshiyasu, OKAMOTO, Kazumi, KUBO, Youko, SHIDA, Naomi, KODAMA, Mitsuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	12-chloroillicinone E 2(R)-12-chloro-2, 3-dihydroillicinone E Animals Benzofurans - isolation & purification Benzofurans - pharmacology Cells, Cultured choline acetyltransferase activity Choline O-Acetyltransferase - metabolism Dioxoles - isolation & purification Dioxoles - pharmacology Illicium tashiroi Magnoliaceae Neurons - drug effects Neurons - enzymology Plant Extracts - isolation & purification Plant Extracts - pharmacology prenylated C6-C3 compound Rats Septal Nuclei - cytology Structure-Activity Relationship
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Zusammenfassung:	The structures of two new chlorine-containing C6-C3 compounds isolated from the woods of Illicium tashiroi have been established as 2(R)-12-chloro-2, 3-dihydroillicinone E (1) and 12-chloroillicinone E (2) by X-ray crystallographic analysis and spectroscopic data, respectively. Compound 1 has been found to significantly increase ChAT activity in culture of P10 rat sepatl neurons.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.42.2199