Interleukin-1-beta changes the expression of metalloproteinases in the vitreous humor and induces membrane formation in eyes containing preexisting retinal holes

Proliferative vitreoretinopathy occurs when cells migrate into the vitreous humor, where they proliferate and produce a membrane composed of extracellular matrix. Interleukin-1-beta (IL-1-beta) may be involved in these processes because it is chemotactic and mitogenic, and it stimulates metalloprote...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1994-12, Vol.35 (13), p.4260-4267
Hauptverfasser:	Kosnosky, W, Li, TH, Pakalnis, VA, Fox, A, Hunt, RC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane - drug effects Basement Membrane - pathology Biological and medical sciences Electrophoresis, Polyacrylamide Gel Extracellular Matrix - drug effects Extracellular Matrix - pathology Injections Interleukin-1 - physiology Medical sciences Metalloendopeptidases - biosynthesis Ophthalmology Rabbits Retina - drug effects Retina - pathology Retinal Perforations - complications Retinopathies Vitreoretinopathy, Proliferative - etiology Vitreoretinopathy, Proliferative - pathology Vitreoretinopathy, Proliferative - physiopathology Vitreous Body - drug effects Vitreous Body - enzymology
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