TAN-1496 A, C AND E, DIKETOPIPERAZINE ANTIBIOTICS WITH INHIBITORY ACTIVITY AGAINST MAMMALIAN DNA TOPOISOMERASE I

Fungal metabolites with an epi-oligothiadiketopiperazine structure, TAN-1496 A, C and E, were isolated from the culture broth of Microsphaeropsis sp. FL-16144. Their molecular formulas were determined to be C22H28N2O9S2, C22H28N2O9S3 and C22H28N2O9S4, respectively. Structures were determined by comp...

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Veröffentlicht in:	Journal of antibiotics 1994/11/25, Vol.47(11), pp.1202-1218
Hauptverfasser:	FUNABASHI, YASUNORI, HORIGUCHI, TAKASHI, IINUMA, SHIGEMI, TANIDA, SEIICHI, HARADA, SETSUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antineoplastic agents Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fermentation General aspects Humans Medical sciences Mice Microsphaeropsis Mitosporic Fungi - classification Mitosporic Fungi - metabolism Pharmacology. Drug treatments Piperazines - chemistry Piperazines - isolation & purification Piperazines - pharmacology Structure-Activity Relationship Topoisomerase I Inhibitors
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