Isozyme-specific inhibition of protein kinase C by RNA aptamers

In vitro selection technology has been used to purify RNA aptamers from a random sequence pool that can bind to, and specifically inhibit, protein kinase C beta II. Two of the selected RNA aptamers bind to this isozyme of protein kinase C with nanomolar affinities and inhibit activation with unprece...

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Veröffentlicht in:	The Journal of biological chemistry 1994-12, Vol.269 (51), p.32051-32054
Hauptverfasser:	Conrad, R, Keranen, L M, Ellington, A D, Newton, A C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cattle DNA Primers Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Molecular Sequence Data Nucleic Acid Conformation Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism RNA - chemistry RNA - metabolism RNA Splicing
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