Utility of Gastrointestinal Physiology Regulated-Dogs : Bioavailability Study of a Commercial sustained-Release Dosage Form of Theophylline
The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded a...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1994/07/15, Vol.17(7), pp.931-934 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | SAGARA, Kazuyoshi KAWATA, Miwako MIZUTA, Hiroaki SHIBATA, Masahiro |
| description | The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is absorbed completely in the entire gastrointestinal tract but slowly in the colon for humans. A commercial sustained-release tablet (SR tablet) of theophylline and a commercial conventional tablet of aminophylline (theophylline hemiethilenediamine salt) were chosen as model preparations in this study. In the regulated-dogs, the drug absorption was almost complete for the conventional tablet. The bioavailability of the SR table accounted for 76% in the regulated-dogs and 71% in intact dogs relative to that of the conventional tablet in the regulated-dogs, respectively, but no significant difference was detectable between these values. An advantage of the regulated-dogs over the intact dogs was, however, revealed in the time-profiles of the cumulative percentage of theophylline absorbed from the SR tablet, suggesting a modification of drug absorption by the prolonged arrival of the tablet to the colon. |
| doi_str_mv | 10.1248/bpb.17.931 |
| format | Article |
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The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is absorbed completely in the entire gastrointestinal tract but slowly in the colon for humans. A commercial sustained-release tablet (SR tablet) of theophylline and a commercial conventional tablet of aminophylline (theophylline hemiethilenediamine salt) were chosen as model preparations in this study. In the regulated-dogs, the drug absorption was almost complete for the conventional tablet. The bioavailability of the SR table accounted for 76% in the regulated-dogs and 71% in intact dogs relative to that of the conventional tablet in the regulated-dogs, respectively, but no significant difference was detectable between these values. An advantage of the regulated-dogs over the intact dogs was, however, revealed in the time-profiles of the cumulative percentage of theophylline absorbed from the SR tablet, suggesting a modification of drug absorption by the prolonged arrival of the tablet to the colon.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.17.931</identifier><identifier>PMID: 8000380</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>animal model ; Animals ; beagle dog ; bioavailability ; Biological and medical sciences ; Biological Availability ; Delayed-Action Preparations ; Dogs - metabolism ; gastrointestinal physiology ; Intestinal Absorption ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Respiratory system ; Solubility ; sustained release ; theophylline ; Theophylline - administration & dosage ; Theophylline - pharmacokinetics</subject><ispartof>Biological and Pharmaceutical Bulletin, 1994/07/15, Vol.17(7), pp.931-934</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3411731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8000380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAGARA, Kazuyoshi</creatorcontrib><creatorcontrib>KAWATA, Miwako</creatorcontrib><creatorcontrib>MIZUTA, Hiroaki</creatorcontrib><creatorcontrib>SHIBATA, Masahiro</creatorcontrib><title>Utility of Gastrointestinal Physiology Regulated-Dogs : Bioavailability Study of a Commercial sustained-Release Dosage Form of Theophylline</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is absorbed completely in the entire gastrointestinal tract but slowly in the colon for humans. A commercial sustained-release tablet (SR tablet) of theophylline and a commercial conventional tablet of aminophylline (theophylline hemiethilenediamine salt) were chosen as model preparations in this study. In the regulated-dogs, the drug absorption was almost complete for the conventional tablet. The bioavailability of the SR table accounted for 76% in the regulated-dogs and 71% in intact dogs relative to that of the conventional tablet in the regulated-dogs, respectively, but no significant difference was detectable between these values. An advantage of the regulated-dogs over the intact dogs was, however, revealed in the time-profiles of the cumulative percentage of theophylline absorbed from the SR tablet, suggesting a modification of drug absorption by the prolonged arrival of the tablet to the colon.</description><subject>animal model</subject><subject>Animals</subject><subject>beagle dog</subject><subject>bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Delayed-Action Preparations</subject><subject>Dogs - metabolism</subject><subject>gastrointestinal physiology</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiratory system</subject><subject>Solubility</subject><subject>sustained release</subject><subject>theophylline</subject><subject>Theophylline - administration & dosage</subject><subject>Theophylline - pharmacokinetics</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFv1DAQhS0EKkvhwh0pB8QBKYsdJ3HCDba0IFUClfZsjZ1J1pUTL7aDlN_An8bbrPZiW_O-eU9-hLxldMuKsvmkDmrLxLbl7BnZMF6KvCpY9ZxsaMuavGZV85K8CuGRUipowS_IRZOevKEb8u8hGmvikrk-u4EQvTNTxBDNBDb7tV-CcdYNS3aHw2whYpdfuSFkn7OvxsFfMBbUuv87zt2TC2Q7N47otUkOYQ4RzJTW7tAiBMyuXIABs2vnxyN9v0d32C_WJug1edGDDfjmdF-Sh-tv97vv-e3Pmx-7L7e5rjiPuaKq0KzsSqUxDZAD7XotKooKm06UfcOFqHlZ667va6pVmVrQPQC0Fe0E5Zfkw-p78O7PnD4rRxM0WgsTujlIUbe0EHWRwI8rqL0LwWMvD96M4BfJqDw2L1PzkgmZmk_wu5PrrEbszuip6qS_P-kQNNjew6RNOGO8ZEw82exW7DE1N-BZBx-NtnhMZG3Lj6liPVL4WdV78BIn_h-cz6Zq</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>SAGARA, Kazuyoshi</creator><creator>KAWATA, Miwako</creator><creator>MIZUTA, Hiroaki</creator><creator>SHIBATA, Masahiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Utility of Gastrointestinal Physiology Regulated-Dogs : Bioavailability Study of a Commercial sustained-Release Dosage Form of Theophylline</title><author>SAGARA, Kazuyoshi ; KAWATA, Miwako ; MIZUTA, Hiroaki ; SHIBATA, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-b0b2c14d4bce533e3a0dfc750ebe8d74f83776346cdff60cb4918cfaaa950d703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>animal model</topic><topic>Animals</topic><topic>beagle dog</topic><topic>bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Delayed-Action Preparations</topic><topic>Dogs - metabolism</topic><topic>gastrointestinal physiology</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiratory system</topic><topic>Solubility</topic><topic>sustained release</topic><topic>theophylline</topic><topic>Theophylline - administration & dosage</topic><topic>Theophylline - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAGARA, Kazuyoshi</creatorcontrib><creatorcontrib>KAWATA, Miwako</creatorcontrib><creatorcontrib>MIZUTA, Hiroaki</creatorcontrib><creatorcontrib>SHIBATA, Masahiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAGARA, Kazuyoshi</au><au>KAWATA, Miwako</au><au>MIZUTA, Hiroaki</au><au>SHIBATA, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of Gastrointestinal Physiology Regulated-Dogs : Bioavailability Study of a Commercial sustained-Release Dosage Form of Theophylline</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1994</date><risdate>1994</risdate><volume>17</volume><issue>7</issue><spage>931</spage><epage>934</epage><pages>931-934</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is absorbed completely in the entire gastrointestinal tract but slowly in the colon for humans. A commercial sustained-release tablet (SR tablet) of theophylline and a commercial conventional tablet of aminophylline (theophylline hemiethilenediamine salt) were chosen as model preparations in this study. In the regulated-dogs, the drug absorption was almost complete for the conventional tablet. The bioavailability of the SR table accounted for 76% in the regulated-dogs and 71% in intact dogs relative to that of the conventional tablet in the regulated-dogs, respectively, but no significant difference was detectable between these values. An advantage of the regulated-dogs over the intact dogs was, however, revealed in the time-profiles of the cumulative percentage of theophylline absorbed from the SR tablet, suggesting a modification of drug absorption by the prolonged arrival of the tablet to the colon.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8000380</pmid><doi>10.1248/bpb.17.931</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1994/07/15, Vol.17(7), pp.931-934 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | animal model Animals beagle dog bioavailability Biological and medical sciences Biological Availability Delayed-Action Preparations Dogs - metabolism gastrointestinal physiology Intestinal Absorption Male Medical sciences Pharmacology. Drug treatments Respiratory system Solubility sustained release theophylline Theophylline - administration & dosage Theophylline - pharmacokinetics |
| title | Utility of Gastrointestinal Physiology Regulated-Dogs : Bioavailability Study of a Commercial sustained-Release Dosage Form of Theophylline |
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