Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations we...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-12, Vol.266 (5193), p.2011-2015
Hauptverfasser:	Kim, Nam W., Piatyszek, Mieczyslaw A., Prowse, Karen R., Harley, Calvin B., West, Michael D., Peter L. C. Ho, Coviello, Gina M., Wright, Woodring E., Weinrich, Scott L., Shay, Jerry W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Cancer Cancer cells Cell Division Cell extracts Cell Line Cell Line, Transformed - enzymology Cell lines Cell proliferation Cells DNA biosynthesis DNA Nucleotidylexotransferase - metabolism Enzyme Activation Enzyme Repression Enzymes Female Fibroblasts HEK293 cells Host-tumor relations. Immunology. Biological markers Humans Kidney cells Male man Medical research Medical sciences Molecular Sequence Data Neoplasms - enzymology Ovary - enzymology Polymerase Chain Reaction Somatic cells Squamous cell carcinoma telomerase Telomeres Testis - enzymology Tumor Cells, Cultured Tumors
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