ISOLATION AND STRUCTURE ELUCIDATION OF TWO NEW CALPAIN INHIBITORS FROM Streptomyces griseus

Two new peptides, a diketopiperazine of N-methyltyrosine (1) and a tetrapeptide containing N-methyltyrosine (2), were isolated from an actinomycete strain Streptomyces griseujs. These compounds inhibit the enzyme calpain in the micromolar range and were characterized on the basis of spectroscopic an...

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Veröffentlicht in:	Journal of antibiotics 1994/11/25, Vol.47(11), pp.1195-1201
Hauptverfasser:	ALVAREZ, M. ESTELA, HOUCK, DAVID R., WHITE, CAROLE B., BROWNELL, JAMES E., BOBKO, MARK A., RODGER, CHARLES A., STAWICKI, MARY B., SUN, HAO H., GILLUM, AMANDA M., COOPER, RAYMOND
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Calpain - antagonists & inhibitors Chemotherapic agents Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Microbiology Oligopeptides - chemistry Oligopeptides - isolation & purification Oligopeptides - pharmacology Piperazines - chemistry Piperazines - isolation & purification Piperazines - pharmacology Streptomyces griseus Streptomyces griseus - metabolism Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - isolation & purification Tyrosine - pharmacology
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