2,4-Diamino-5-chloroquinazoline Analogs of Trimetrexate and Piritrexim: Synthesis and Antifolate Activity

Ten heretofore undescribed 2,4-diamino-5-chloroquinazoline analogues of trimetrexate (TMQ) and piritrexim (PTX) were synthesized and tested as inhibitors of dihydrofolate reductase (DHFR) from rat liver, Pneumocystis carinii, and Toxoplasma gondii. The most active quinazolines against both the P. ca...

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Veröffentlicht in:	Journal of medicinal chemistry 1994-12, Vol.37 (26), p.4522-4528
Hauptverfasser:	Rosowsky, Andre, Mota, Clara E, Wright, Joel E, Queener, Sherry F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Folic Acid Antagonists - chemical synthesis Folic Acid Antagonists - pharmacology Humans Pyrimidines - pharmacology Rats Structure-Activity Relationship Trimetrexate - analogs & derivatives Trimetrexate - pharmacology
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