Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {18F} fluorodeoxyglucose positron emission tomography and...

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Veröffentlicht in:	Annals of neurology 1994-12, Vol.36 (6), p.925-927
Hauptverfasser:	Henry, Thomas R., Babb, Thomas L., Engel Jr, Jerome, Mazziotta, John C., Phelps, Michael E., Crandall, Paul H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Epilepsy, Temporal Lobe - diagnostic imaging Epilepsy, Temporal Lobe - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - diagnostic imaging Hippocampus - metabolism Humans Medical sciences Nervous system (semeiology, syndromes) Neurology Neurons - diagnostic imaging Neurons - metabolism Tomography, Emission-Computed
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Zusammenfassung:	The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {18F} fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410360620