Autopsy Findings In Aids Patients With Mycobacterium avium Complex Bacteremia
To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes...
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| Veröffentlicht in: | The Journal of infectious diseases 1994-12, Vol.170 (6), p.1601-1605 |
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| container_title | The Journal of infectious diseases |
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| creator | Torriani, Francesca J. Mccutchan, J. Allen Bozzette, Samuel A. Grafe, Marjorie R. Havlir, Diane V. |
| description | To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease. |
| doi_str_mv | 10.1093/infdis/170.6.1601 |
| format | Article |
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Allen ; Bozzette, Samuel A. ; Grafe, Marjorie R. ; Havlir, Diane V.</creator><creatorcontrib>Torriani, Francesca J. ; Mccutchan, J. Allen ; Bozzette, Samuel A. ; Grafe, Marjorie R. ; Havlir, Diane V.</creatorcontrib><description>To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/170.6.1601</identifier><identifier>PMID: 7996004</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; AIDS-Related Opportunistic Infections - microbiology ; AIDS-Related Opportunistic Infections - pathology ; AIDS/HIV ; Autopsies ; Autopsy ; Bacteremia ; Bacteremia - microbiology ; Bacteremia - pathology ; Biological and medical sciences ; Blood ; Bone Marrow - microbiology ; Bone Marrow - pathology ; Cohort Studies ; Concise Communications ; Digestive System - microbiology ; Digestive System - pathology ; Female ; Fungal infections ; Histiocytes - pathology ; Histology ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Lung - microbiology ; Lung - pathology ; Lymphoid Tissue - microbiology ; Lymphoid Tissue - pathology ; Male ; Medical sciences ; Mycobacterium avium ; Mycobacterium avium complex ; Mycobacterium avium Complex - isolation & purification ; Mycobacterium avium-intracellulare Infection - microbiology ; Mycobacterium avium-intracellulare Infection - pathology ; Pathology ; Retrospective Studies ; Spleen</subject><ispartof>The Journal of infectious diseases, 1994-12, Vol.170 (6), p.1601-1605</ispartof><rights>Copyright 1994 The University of Chicago</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-2486b9b498faa0ca4468a24b1fa1eb6b1e40bd6c2e0b959a807690bab3c785a13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30133680$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30133680$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3336686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7996004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torriani, Francesca J.</creatorcontrib><creatorcontrib>Mccutchan, J. Allen</creatorcontrib><creatorcontrib>Bozzette, Samuel A.</creatorcontrib><creatorcontrib>Grafe, Marjorie R.</creatorcontrib><creatorcontrib>Havlir, Diane V.</creatorcontrib><title>Autopsy Findings In Aids Patients With Mycobacterium avium Complex Bacteremia</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.</description><subject>Adult</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - microbiology</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>AIDS/HIV</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Bacteremia</subject><subject>Bacteremia - microbiology</subject><subject>Bacteremia - pathology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone Marrow - microbiology</subject><subject>Bone Marrow - pathology</subject><subject>Cohort Studies</subject><subject>Concise Communications</subject><subject>Digestive System - microbiology</subject><subject>Digestive System - pathology</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Histiocytes - pathology</subject><subject>Histology</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Lymphoid Tissue - microbiology</subject><subject>Lymphoid Tissue - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium complex</subject><subject>Mycobacterium avium Complex - isolation & purification</subject><subject>Mycobacterium avium-intracellulare Infection - microbiology</subject><subject>Mycobacterium avium-intracellulare Infection - pathology</subject><subject>Pathology</subject><subject>Retrospective Studies</subject><subject>Spleen</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEQhi0EKqHlB3BA2gPitqm99o7XxzSiaaUGONAPcbHGXi-47Ee69qLm3-OQ0B65eOR53nln9BLyjtE5o4qf-r6pfThlks5hzoCyF2TGSi5zAMZfkhmlRZGzSqnX5E0I95RSwUEekSOpFKTPjKwXUxw2YZud-772_Y-QXfbZwtch-4rRuz6G7NbHn9l6aweDNrrRT12Gv3fvcug2rXvMzv72XefxhLxqsA3u7aEek-vzT9-WF_nVl9XlcnGVW8Eg5oWowCgjVNUgUotCQIWFMKxB5gwY5gQ1NdjCUaNKhRWVoKhBw62sSmT8mHzc-27G4WFyIerOB-vaFns3TEFLqBRlJfxXyKCiheQ8CdleaMchhNE1ejP6DsetZlTvstb7rHXKWoPeZZ1m3h_MJ9O5-mniEG7iHw4cg8W2GbG3yeGfLG0FqODZ5j7EYXzGaQNP5yWe77kP0T0-cRx_aZBclvri7rsuVmef12J1o2_5HwiBoPc</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Torriani, Francesca J.</creator><creator>Mccutchan, J. Allen</creator><creator>Bozzette, Samuel A.</creator><creator>Grafe, Marjorie R.</creator><creator>Havlir, Diane V.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Autopsy Findings In Aids Patients With Mycobacterium avium Complex Bacteremia</title><author>Torriani, Francesca J. ; Mccutchan, J. Allen ; Bozzette, Samuel A. ; Grafe, Marjorie R. ; Havlir, Diane V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-2486b9b498faa0ca4468a24b1fa1eb6b1e40bd6c2e0b959a807690bab3c785a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - microbiology</topic><topic>AIDS-Related Opportunistic Infections - pathology</topic><topic>AIDS/HIV</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Bacteremia</topic><topic>Bacteremia - microbiology</topic><topic>Bacteremia - pathology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone Marrow - microbiology</topic><topic>Bone Marrow - pathology</topic><topic>Cohort Studies</topic><topic>Concise Communications</topic><topic>Digestive System - microbiology</topic><topic>Digestive System - pathology</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Histiocytes - pathology</topic><topic>Histology</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. 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Allen</creatorcontrib><creatorcontrib>Bozzette, Samuel A.</creatorcontrib><creatorcontrib>Grafe, Marjorie R.</creatorcontrib><creatorcontrib>Havlir, Diane V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torriani, Francesca J.</au><au>Mccutchan, J. Allen</au><au>Bozzette, Samuel A.</au><au>Grafe, Marjorie R.</au><au>Havlir, Diane V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autopsy Findings In Aids Patients With Mycobacterium avium Complex Bacteremia</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>170</volume><issue>6</issue><spage>1601</spage><epage>1605</epage><pages>1601-1605</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>7996004</pmid><doi>10.1093/infdis/170.6.1601</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1994-12, Vol.170 (6), p.1601-1605 |
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| subjects | Adult AIDS AIDS-Related Opportunistic Infections - microbiology AIDS-Related Opportunistic Infections - pathology AIDS/HIV Autopsies Autopsy Bacteremia Bacteremia - microbiology Bacteremia - pathology Biological and medical sciences Blood Bone Marrow - microbiology Bone Marrow - pathology Cohort Studies Concise Communications Digestive System - microbiology Digestive System - pathology Female Fungal infections Histiocytes - pathology Histology Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Lung - microbiology Lung - pathology Lymphoid Tissue - microbiology Lymphoid Tissue - pathology Male Medical sciences Mycobacterium avium Mycobacterium avium complex Mycobacterium avium Complex - isolation & purification Mycobacterium avium-intracellulare Infection - microbiology Mycobacterium avium-intracellulare Infection - pathology Pathology Retrospective Studies Spleen |
| title | Autopsy Findings In Aids Patients With Mycobacterium avium Complex Bacteremia |
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